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Publikováno v:
Cancer Research. 70:4095-4095
Liver cancer (hepatocellular carcinoma, HCC) is a major malignancy worldwide. Despite definite improvements in the outcome of patients with HCC, the overall prognosis of this cancer is still unsatisfactory because of late presentation and frequent tu
Publikováno v:
Cancer Research. 70:4712-4712
Both estrogen-2,3-quinone (E2-2,3-Q) and estrogen-3,4-quinone (E2-3,4-Q) are reactive metabolites of estrogen that are thought to be responsible for the estrogen-induced genotoxicity. The aim of this study was to establish a methodology to analyze es
Autor:
Melissa J. LaBonte, Robert D. Ladner, Heinz-Josef Lenz, Peter M. Wilson, Anthony B. El-Khoueiry
Publikováno v:
Cancer Research. 70:5438-5438
Colorectal cancer (CRC) is the third most commonly diagnosed cancer in the United States. Effective treatment is hindered by the high incidence of drug resistance and tumor recurrence, resulting in the need to identify and exploit novel therapeutic t
Publikováno v:
Cancer Research. 70:4231-4231
Objective: The objective of this study was to investigate changes in CD133 expression and in tumorigenesis that occur in ovarian cancer cell lines treated with drugs that alter gene methylation. Materials and Methods: We selected two common drugs 5-a
Autor:
Salvatore Siena, Miriam Martini, Sara De Dosso, Francesca Molinari, Federico Pozzi, Andrea Bianchi, Milo Frattini, Silvio Veronese, Piercarlo Saletti, Michele Nichelatti, Simona Lamba, Federica Di Nicolantonio, Alberto Bardelli, Luca Mazzucchelli, Carolina Sarnataro
Publikováno v:
Molecular Cancer Therapeutics. 8:B229-B229
Personalized cancer medicine based on the genetic milieu of individual tumors has long been postulated but until recently this concept was not supported by clinical evidence. The advent of the EGFR-targeted monoclonal antibodies cetuximab and panitum
Autor:
Barbara Sennino, Ryan M. Naylor, Dana T. Aftab, Donald M. McDonald, Weon-Kyoo You, Sébastien Tabruyn
Publikováno v:
Molecular Cancer Therapeutics. 8:A13-A13
Inhibition of vascular endothelial growth factor receptor (VEGFR) signaling can slow tumor growth and prolong host survival but can also promote invasiveness and metastasis in some preclinical models. Although the mechanisms involved are unclear, hyp
Publikováno v:
Cancer Prevention Research. 1:A32-A32
A32 Dietary factors play an important role in the pathogenesis of colorectal cancer (CRC), due in part to the influence of the bile acids. While the secondary bile acid, deoxycholic acid (DCA), has been associated with tumor promotion, one tertiary b