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Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 19:1160-1166
Background: We sought to determine the optimal plasma and urine nicotine metabolites, alone or in combination, to estimate the systemic dose of nicotine after low-level exposure. Methods: We dosed 36 nonsmokers with 100, 200, or 400 μg p.o. of deute
Autor:
Marcus A. Neubauer, Timothy Lopez, Howard A. Burris, Paul D. Swanson, Jordan Berlin, J. Randolph Hecht, Maureen Reiner, Glenn Buchanan, Edith P. Mitchell, Jennifer Gansert
Publikováno v:
Clinical Cancer Research. 16:2205-2213
Purpose: Panitumumab, a fully human anti–epidermal growth factor receptor (EGFR) monoclonal antibody, is approved as monotherapy for the treatment of metastatic colorectal cancer. We evaluated the association of tumor EGFR expression levels with ou
Autor:
Jagadeesan Nair, Paiboon Sitthithaworn, Puangrat Yongvanit, Somchai Pinlaor, Helmut Bartsch, Somkid Dechakhamphu
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 19:310-318
Chronic infection by the liver fluke Opisthorchis viverrini is a strong risk factor for cholangiocarcinoma. To clarify the involvement of oxidative stress and lipid peroxidation–derived DNA damage, etheno (ϵ)-DNA adducts (ϵdA, ϵdC) in WBC and pl
Autor:
Shuji Ogino, Richard M. Goldberg, Alexander Hantel, Al B. Benson, Paul L. Schaefer, Monica M. Bertagnolli, Renaud Whittom, Leonard B. Saltz, Robert J. Mayer, Donna Hollis, Donna Niedzwiecki, Natsumi Irahara, Charles S. Fuchs, Jeffrey A. Meyerhardt
Publikováno v:
Clinical Cancer Research. 15:7322-7329
Purpose: Alterations in the RAS and RAF pathway relate to epigenetic and epigenomic aberrations, and are important in colorectal carcinogenesis. KRAS mutation in metastatic colorectal cancer predicts resistance to anti–epidermal growth factor recep
Autor:
Douglas Grossman, Pamela B. Cassidy, Mark Wade, Tong Liu, Murray A. Cotter, Agnessa Gadeliya Goodson, Kenneth M. Boucher, Scott R. Florell
Publikováno v:
Clinical Cancer Research. 15:7434-7440
Purpose: Induction of oxidative stress has been implicated in UV-induced melanoma. We sought to determine whether the antioxidant N-acetylcysteine (NAC) could be safely administered to protect melanocytic nevi from the oxidative stress resulting from
Publikováno v:
Cancer Research. 69:7619-7625
Circadian rhythms regulate diverse physiologic processes, including homeostatic functions of steroid hormones and their receptors. Perturbations of these rhythms are associated with pathogenic conditions, such as depression, diabetes, and cancer. And
Autor:
Cristina M. Karp, Eileen White, Kevin Bray, Robert S. DiPaola, Hsin-Yi Chen, Michael May, Shridar Ganesan, Vassiliki Karantza-Wadsworth
Publikováno v:
Molecular Cancer Research. 7:1487-1496
Apoptosis resistance is a hallmark of cancer linked to disease progression and treatment resistance, which has led to the development of anticancer therapeutics that restore apoptotic function. Antiapoptotic Bcl-2 is frequently overexpressed in refra
Autor:
Vincent A. Miller, Pasi A. Jänne, David M. Jackman, Marielle Gallegos Ruiz, Gregory J. Riely, Beow Y. Yeap, Bruce E. Johnson, Lecia V. Sequist, Giuseppe Giaccone, Leigh-Anne Cioffredi
Publikováno v:
Clinical Cancer Research. 15:5267-5273
Purpose: The impact of epidermal growth factor receptor (EGFR) and KRAS genotypes on outcomes with erlotinib or gefitinib therapy continues to be debated. This study combines patient data from five trials in predominantly Western populations to asses
Autor:
Hsiang Lin Tsai, Hwei-Ming Wang, Jaw-Yuan Wang, Shiu-Ru Lin, Chien-Yu Lu, Yung-Sung Yeh, Yu-Tang Chang, Koung-Shing Chu, Chao-Wen Chen, Li-Chen Yen
Publikováno v:
Clinical Cancer Research. 15:4508-4513
Purpose: Previously we developed membrane-arrays as a promising tool to detect circulating tumor cells (CTC) with KRAS oncogene in patients with malignancies. This study was conducted to determinate the predictive values of CTCs with KARS mutation by
Proliferation of Immature Tumor Vessels Is a Novel Marker of Clinical Progression in Prostate Cancer
Publikováno v:
Cancer Research. 69:4708-4715
Background: High-risk human papilloma virus (HPV) infection is associated with the carcinogenesis in head and neck squamous carcinoma (HNSCC), especially in oropharynx . Several molecular and clinical studies have revealed that the molecular alternat