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Publikováno v:
Clinical Cancer Research. 17:6338-6346
Purpose: Monoclonal antibodies against the epidermal growth factor receptor (EGFR), such as cetuximab, have led to significant clinical benefits for metastatic colorectal cancer (mCRC) patients but have also increased treatment costs considerably. Re
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 20:1524-1536
Background: This multicenter, observational study was conducted in three European countries (Germany, Switzerland, and the United Kingdom) to determine the exposure of adult cigarette smokers and nonsmokers to selected cigarette smoke constituents: 1
Autor:
Marc Ladanyi, Ronglai Shen, Maureen F. Zakowski, Naiyer A. Rizvi, Bernard J. Park, Mark G. Kris, Jamie E. Chaft, Robert T. Heelan, Christopher G. Azzoli, Raja M. Flores, William Pao, Bhuvanesh Singh, Manjit S. Bains, Vincent A. Miller, Valerie W. Rusch, Lee M. Krug, Robert J. Downey
Publikováno v:
Clinical Cancer Research. 17:3500-3506
Purpose: To determine if tumor regression following treatment with gefitinib correlates with the presence of sensitizing mutations in epidermal growth factor receptor (EGFR). Patients and Methods: Patients with resectable stage I and II non–small c
Autor:
Peter L. Choyke, Liqiang Xi, Jeremy Force, Corrine Keen, Mark Raffeld, Martin Gutierrez, Ariel Lopez-Chavez, Baris Turkbey, Liang Cao, Ronan J. Kelly, Seth M. Steinberg, John J. Wright, Shivaani Kummar, Yunkai Yu, Arun Rajan, Giuseppe Giaccone
Publikováno v:
Clinical Cancer Research. 17:1190-1199
Purpose: Sorafenib, a multikinase inhibitor targeting Raf and VEGFR, has shown activity in unselected patients with non–small-cell lung cancer (NSCLC). At present there are no validated biomarkers indicative of sorafenib activity. Experimental Desi
Autor:
Mariano Provencio, Charles L. Sawyers, Bartomeu Massuti, Felipe Cardenal, Sara Simonetti, Itziar de Aguirre, Susana Benlloch, Cristina Queralt, Miquel Taron, Rosario García-Campelo, R. Porta, Jose Miguel Sanchez, Trever G. Bivona, Carlota Costa, Clara Mayo, Dolores Isla, Miguel Angel Molina, Noemi Reguart, Aurelio Ariza, Santiago Viteri, Margarita Majem, Jordi Bertran-Alamillo, Enric Carcereny, Jose Javier Sanchez, Jose Luis Mate, Maria Sanchez-Ronco, Manuel Cobo, A. Insa, Anna Gimenez-Capitan, Pedro Mendez, Teresa Moran, Rafael Rosell
Publikováno v:
CLINICAL CANCER RESEARCH
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Purpose: Advanced non–small-cell lung cancer (NSCLC) patients harboring epidermal growth factor receptor (EGFR) mutations (deletion in exon 19 or L858R) show an impressive progression-free survival of 14 months when treated with erlotinib. However,
Autor:
Caroline Flament, Sophie Viaud, Mustapha Zoubir, Vincent Ribrag, Jean-Charles Soria, Nathalie Chaput, Patricia Pautier, Virginie Marty, Caroline Robert, A. Lecesne, Laurence Zitvogel, Philippe Vielh
Publikováno v:
Cancer Research. 71:661-665
Low doses of the alkylating agent cyclophosphamide (CTX) mediate antiangiogenic and immunostimulatory effects, leading to potent tumoricidal activity in association with various immunotherapeutic strategies. Here, we show in rodents and cancer patien
Publikováno v:
Cancer Research. 71:445-453
Epidermal growth factor receptor (EGFR) monoclonal antibodies (mAb) are used widely to treat metastatic colorectal cancer (mCRC) patients, but it is now clear that patients harboring K-ras mutation are resistant to EGFR mAbs such as cetuximab (Erbitu
Autor:
Kiminobu Arima, Yoshiki Sugimura, Yoichi Iwamoto, Kenichiro Ishii, Hideki Kanda, Yasuhide Hori, Hideaki Kise, Norihito Soga, Kohei Nishikawa
Publikováno v:
Cancer Prevention Research. 4:87-96
In prostate cancer, tumor–stroma interactions play a critical role in the promotion of tumorigenesis, and thus the prevention of those interactions is a promising target to suppress tumor growth. Several studies demonstrated that alpha1-adrenocepto
Autor:
Bharat B. Aggarwal, Sanjit Dey, Sushovan Guha, Zhimin Tong, Parmeswaran Diagaradjane, Juri G. Gelovani, Vivek R. Yadav, Cemile Koca, Jayaraj Ravindran, Bokyung Sung, Sunil Krishnan, Ajaikumar B. Kunnumakkara, Amit Deorukhkar
Publikováno v:
Cancer Research. 70:8695-8705
Pancreatic cancers generally respond poorly to chemotherapy, prompting a need to identify agents that could sensitize tumors to treatment. In this study, we investigated the response of human pancreatic cells to γ-tocotrienol (γ-T3), a novel, unsat
Autor:
Natalie Weisensel, Linda B. von Weymarn, Sharon E. Murphy, Katherine M. Wickham, Elizabeth A. Thompson, Jeannette Zinggeler Berg, Dorothy K. Hatsukami
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 19:1423-1431
Background: Tobacco exposure is routinely assessed by quantifying nicotine metabolites in plasma or urine. On average, 80% of nicotine undergoes C-oxidation to cotinine. However, interindividual variation in nicotine glucuronidation is substantial, a