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pro vyhledávání: '"Allison Berger"'
Autor:
Peter G. Smith, James J. Garnsey, Allison Berger, George Mullligan, Bradley Stringer, Michael D. Pickard, Jie Yu, Kristin E. Burke, Doug Bowman, Alice McDonald, Mark D. Fleming
Publikováno v:
Clinical Cancer Research. 16:A31-A31
The novel small molecule MLN4924 is an inhibitor of the NEDD8 activating enzyme (NAE) and is currently in Phase I trials. As part of the ubiquitin-proteasome system, NAE is required for activity of cullin ring ligases (CRLs), a category of ubiquitin
Autor:
Yu Jie, Julie Zhang, Yu Yang, Erik Kupperman, Mark Fleming, Yueying Cao, Doug Bowman, Jill Donelan, Bradley Stringer, Trisha Babcock, Allison Berger, Eric S. Lightcap, Edmund Lee
Publikováno v:
Molecular Cancer Therapeutics. 8:B40-B40
The ubiquitin-proteasome system processes the majority of cellular proteins and is the principal pathway by which cells regulate protein homeostasis. The successful development of VELCADE® (bortezomib) for Injection for multiple myeloma and previous