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Autor:
Maura N. Dickler, A. Cervantes, Heidi Savage, T. R. Wilson, Cristina Saura, Ian E. Krop, Donald A. Richards, Marcos Vinicius Silva Oliveira, Huan Jin, Thomas J Stout, J. Baselga
Publikováno v:
Cancer Research. 77:P6-12
Background: The phosphatidylinositol 3-kinase (PI3K) pathway is frequently dysregulated in hormone receptor (HR)-positive breast cancer (BC), with activating mutations of PIK3CA detected in ~35–45% of patients (pts). Acquired mutations in the ESR1
Autor:
Rui Xiong, Marton I. Siklos, Jaewoo Choi, Bradley T. Michalsen, Robert A. Scism, R. Esala P. Chandrasena, Emily N. Thayer, Sujeewa C. Piyankarage, Yijin Wang, Shuai Wang, L. P. Madhubhani P. Hemachandra, Judy L. Bolton, Hitisha K. Patel, Gregory R. J. Thatcher
Publikováno v:
Cancer Prevention Research. 7:505-515
The risk of developing hormone-dependent cancers with long-term exposure to estrogens is attributed both to proliferative, hormonal actions at the estrogen receptor (ER) and to chemical carcinogenesis elicited by genotoxic, oxidative estrogen metabol
Autor:
Hariprasad Gali, Taylor Bryant, Altaf Mohammed, Stan Lightfoot, Naveena B. Janakiram, Laura Biddick, Misty Brewer, Gopal Pathuri, Chinthalapally V. Rao
Publikováno v:
Cancer Prevention Research. 7:300-309
Studies suggest that estrogen plays a contributing role in colorectal cancer. This project examined the preventive effects of raloxifene, a selective estrogen receptor modulator (SERM), and gonadorelin, an antiestrogenic drug, in female ApcMin/+ mous
Publikováno v:
Cancer Research. 73:P5-09
Introduction: BP1 is a member of the homeobox gene family of transcription factors. Our recent studies have shown that BP1 may play a role in breast cancer cell survival, aggressiveness and metastasis. BP1 protein (pBP1) is expressed in 80% of invasi
Autor:
Ekaterina G. Shatalova, Andres J. Klein-Szanto, Edna Cukierman, Karthik Devarajan, Margie L. Clapper
Publikováno v:
Cancer Prevention Research. 4:107-115
Squamous cell carcinoma of the head and neck (HNSCC) is the sixth most common type of cancer in the United States. The goal of this study was to evaluate the contribution of estrogens to the development of HNSCCs. Various cell lines derived from earl
Autor:
Eli Pikarsky, Itamar Simon, Michael Elkin, Tamar Peretz, Bella Maly, Irit Cohen, Eyal Zcharia, Amichay Meirovitz, Israel Vlodavsky
Publikováno v:
Clinical Cancer Research. 13:4069-4077
Purpose: Mammalian heparanase degrades heparan sulfate, the main polysaccharide of the basement membrane. Heparanase is an important determinant in cancer progression, acting via the breakdown of extracellular barriers for invasion, as well as releas
Autor:
Daniel Sliva, Shujie Cheng, Victor Castillo, Mark Alvarado, Georg Sandusky, Jagadish Loganathan, Isaac Eliaz
Publikováno v:
Cancer Research. 75:5562-5562
In this study we evaluated the combined effects of the natural product/dietary supplement BreastDefend (BD) and tamoxifen (TAM) on MCF-7 estrogen receptor-positive (ER+) human breast cancer cells in vitro and an orthotopic mouse model in vivo. BD has
Autor:
Austin Layton, Heinz-Josef Lenz, Sybil Magturo, Snay Mallick, Melissa J. LaBonte, Georgios Giamas, Justin Stebbing
Publikováno v:
Cancer Research. 74:4213-4213
Background: Incompatible physiology between genders influences development and progression of colorectal cancer (CRC). It is postulated that improved survival of women with CRC may be due to exogenous estrogen exposure. A recent study used the age of
Publikováno v:
Cancer Research. 74:4514A-4514A
GP88 (Progranulin, PCDGF, acrogranin), the largest member of the granulin/epithelin family was originally characterized in our laboratory as a driver of tumorigenesis. Published evidence showed that 1) GP88 expression increases with tumorigenesis; 2)
Publikováno v:
Cancer Research. 72:P6-04
The 88 kDa glycoprotein GP88 (Progranulin, PCDGF, acrogranin) is the largest member of the granulin/epithelin family of growth modulators characterized by 7.5 cysteine-rich granulin/epithelin repeats. Our laboratory has demonstrated that GP88 represe