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Autor:
Jean-Claude Souberbielle, Thierry Capiod, Arnaud Mejean, Stéphane Oudard, Nicolas Barry Delongchamps, Edouard Reyes-Gomez, Florence Boutillon, Natascha Pigat, Mélanie Viltard, Virginie Verkarre, Eve M. Lepicard, Vincent Goffin, Sophie Bernichtein, Philippe Camparo, Gérard Friedlander
Publikováno v:
Cancer Research. 77:355-365
Active surveillance has emerged as an alternative to immediate treatment for men with low-risk prostate cancer. Accordingly, identification of environmental factors that facilitate progression to more aggressive stages is critical for disease prevent
Autor:
Mariarosaria Di Tommaso, Camilla Fusi, Simone Li Puma, Alyn H. Morice, Pierangelo Geppetti, Romina Nassini, Ilaria M. Marone, Alessandro Terreni, Francesco De Logu, Laura R. Sadofsky, Serena Materazzi, Elisabetta Coppi, Tommaso Susini, Silvia Benemei, Raquel Tonello, Gloriano Moneti
Publikováno v:
Cancer Research. 76:7024-7035
Aromatase inhibitors (AI) induce painful musculoskeletal symptoms (AIMSS), which are dependent upon the pain transducing receptor TRPA1. However, as the AI concentrations required to engage TRPA1 in mice are higher than those found in the plasma of p
Autor:
Anat Stemmer-Rachamimov, Smitha Kota, William Guerrant, Vinay Mandati, Joseph L. Kissil, Mohammad Fallahi, Scott Troutman
Publikováno v:
Cancer Research. 76:3507-3519
The Hippo–YAP pathway has emerged as a major driver of tumorigenesis in many human cancers. YAP is a transcriptional coactivator and while details of YAP regulation are quickly emerging, it remains unknown what downstream targets are critical for t
Autor:
Reuben S. Harris, Jwm Martens, Fred C.G.J. Sweep, Gabriel J. Starrett, Emily K. Law, Nuri A. Temiz, Paul N. Span, AM Sieuwerts, J.A. Foekens, Kelly LaPara, Douglas Yee, Brandon Leonard
Publikováno v:
Cancer Research. 76:S4-07
Recent studies have implicated the DNA cytosine deaminase APOBEC3B as a major source of mutation in breast cancer. APOBEC3B explains a large proportion of both dispersed and clustered cytosine mutations, the latter of which are also called kataegis.
Publikováno v:
Cancer Prevention Research. 13:A46-A46
Purpose: We previously showed diet-induced obesity (DIO) increases (and calorie restriction decreases) systemic markers of inflammation and azoxymethane (AOM)-induced colon carcinogenesis in FVB/N mice. Our current study examines whether moderate wei
Autor:
Chinthalapally V. Rao, Naveena B. Janakiram, Rebekah L. Ritchie, Vernon E. Steele, Altaf Mohammed, Stan Lightfoot, Laura Biddick, Venkateshwar Madka, Jagan M.R. Patlolla, Misty Brewer, Michael Sadeghi
Publikováno v:
Cancer Prevention Research. 7:1198-1209
Ornithine decarboxylase (ODC) is the key rate-limiting enzyme in the polyamine synthesis pathway and it is overexpressed in a variety of cancers. We found that polyamine synthesis and modulation of ODC signaling occurs at early stages of pancreatic p
Publikováno v:
Cancer Research. 76:P3-05
The 88 kDa glycoprotein GP88 (Progranulin, PCDGF, acrogranin) is the largest member of the granulin/epithelin family of growth modulators identified as a driver of tumorigenesis. GP88 (PGRN) was also shown to be overexpressed in invasive ductal carci
Autor:
Hariprasad Gali, Taylor Bryant, Altaf Mohammed, Stan Lightfoot, Naveena B. Janakiram, Laura Biddick, Misty Brewer, Gopal Pathuri, Chinthalapally V. Rao
Publikováno v:
Cancer Prevention Research. 7:300-309
Studies suggest that estrogen plays a contributing role in colorectal cancer. This project examined the preventive effects of raloxifene, a selective estrogen receptor modulator (SERM), and gonadorelin, an antiestrogenic drug, in female ApcMin/+ mous
Publikováno v:
Cancer Research. 73:P5-09
The 88 kDa glycoprotein GP88 (Progranulin, PCDGF, acrogranin) is the largest member of the granulin/epithelin family of growth modulators. GP88 was originally characterized in our laboratory through a biological screen to identify drivers of tumorige
Publikováno v:
Cancer Research. 73:P5-09
Introduction: BP1 is a member of the homeobox gene family of transcription factors. Our recent studies have shown that BP1 may play a role in breast cancer cell survival, aggressiveness and metastasis. BP1 protein (pBP1) is expressed in 80% of invasi