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Autor:
Thahir Farzan, Kimberly R. Kalli, Paul Haluska, Marc A. Becker, S. John Weroha, Tai W. Wong, Sean C. Harrington, James Krempski, Xiaonan Hou
Publikováno v:
Molecular Cancer Therapeutics. 12:2909-2916
Ovarian cancer mortality ranks highest among all gynecologic cancers with growth factor pathways playing an integral role in tumorigenesis, metastatic dissemination, and therapeutic resistance. The HER and VEGF receptor (VEGFR) are both overexpressed
Autor:
Michael Pollak, Carolyn Algire, Olga Moiseeva, Elena Birman, Luca A. Petruccelli, Gerardo Ferbeyre, Benoit Viollet, Lilian Amrein, Xavier Deschênes-Simard
Publikováno v:
Cancer Prevention Research. 5:536-543
Pharmacoepidemiologic studies provide evidence that use of metformin, a drug commonly prescribed for type II diabetes, is associated with a substantial reduction in cancer risk. Experimental models show that metformin inhibits the growth of certain n
Autor:
Young Suk Park, Yoon-La Choi, Joon Oh Park, Hye Lim Jang, Seung Tae Kim, Do Hyoung Lim, Taekyu Lim, Kyung Kee Baek, Ho Yeong Lim, Won Ki Kang, Jeeyun Lee, Jun Ho Yi, Kee Taek Jang, Se Hoon Park
Publikováno v:
Molecular Cancer Therapeutics. 10:1993-1999
Although erlotinib has become an important therapeutic option in addition to gemcitabine, the high frequency of KRAS mutations in pancreatic cancer probably limits the benefits. We retrospectively studied 136 pancreatic cancer patients with available
Autor:
David S. Millington, Ivan Spasojevic, Jeffrey R. Marks, Adviye A. Tolun, Sarah P. Young, Richard T. DiGiulio, Karel Base, P. Kelly Marcom, Frances Wang, Gabriel Mixon, Dora Il'yasova
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 19:1506-1510
Background: We used doxorubicin-based chemotherapy as a clinical model of oxidative assault in humans. Methods: The study recruited newly diagnosed breast cancer patients (n = 23). Urine samples were collected immediately before (T0) and at 1 hour (T
Publikováno v:
Cancer Research. 64:1737-1743
PC cell-derived growth factor, also known as progranulin, is an Mr 88,000 growth factor (referred as PCDGF/GP88) overexpressed in human breast cancer. Antisense inhibition of PCDGF/GP88 expression in MDA-MB-468 cells inhibited tumor formation in nude
Autor:
Jeffrey Norris, Regan M. Memmott, Kristin J. Lastwika, Phillip A. Dennis, Joell J. Gills, Krista Pearman
Publikováno v:
Cancer Research. 76:4330-4330
Lung cancer is the leading cause of cancer-related mortality worldwide, and 85% of lung cancer cases are associated with tobacco use. Within this group, activating mutations in K-ras have been identified in ∼25% of lung adenocarcinomas. Using a mou
Publikováno v:
Cancer Prevention Research. 8:B23-B23
Lung cancer is the leading cause of cancer-related mortality worldwide, and 85% of lung cancers are associated with tobacco use. Activating mutations in K-ras have been identified in ~25% of lung adenocarcinomas and are found predominantly in smokers
Publikováno v:
Cancer Research. 73:2273-2273
Metformin is a bi-guanidine employed in treating Type II diabetes. Epidemiologic studies have suggested that diabetics receiving metformin vs thialidizones or insulin have a lower incidence of cancer. In addition, metformin decreases levels of AMPK a
Publikováno v:
Cancer Research. 71:4589-4589
Our previous studies indicate that specific forms of vitamin E such as gamma-tocopherol (gT), the predominant form of vitamin E in US diets, have anti-inflammatory activities by inhibition of proinflammatory eicosanoids including prostaglandin E2 and
Publikováno v:
Cancer Research. 71:3549-3549
Pancreatic ductal adenocarcinoma (PDA) is a highly lethal human malignancy with dismal prognosis and few effective therapeutic options. Novel agents that are safe and effective are urgently needed. Oleanolic acid-derived synthetic triterpenoids are p