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pro vyhledávání: '"Jacob H"'
Publikováno v:
Cancer Research. 77:592-592
Checkpoint blockade is able to achieve durable responses in a subset of patients, however the biological variables that distinguish responders from non-responders are not well understood. Furthermore, we lack a satisfying comprehension of the underly
Autor:
Harris G. Fienberg, Ina Radtke, Kara L. Davis, Dana Pe'er, Garry P. Nolan, Jacob H. Levine, El-ad David Amir, Sean C. Bendall, Amanda Larson Gedman, James R. Downing, Astraea Jager, Erin F. Simonds, Wendy J. Fantl
Publikováno v:
Cancer Research. 73:3178-3178
Acute myeloid leukemia (AML) can present with multiple concurrent subclones at diagnosis. Subclone-specific mutations may confer resistance to molecular-targeted drugs through loss of antigen expression or rewiring of intracellular signaling pathways