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Autor:
Amy Zhang, Grainne M. O'Kane, Paz Polak, Celia M. T. Greenwood, James Joseph Biagi, Sandra Fischer, Julie M. Wilson, Louis-Martin Boucher, Gun Ho Jang, Zu-Hua Gao, Jennifer J. Knox, Yifan Wang, Yasser Riazalhosseini, Nathaniel Bouganim, Ayelet Borgida, David Valenti, Robert C. Grant, Steven Gallinger, Mehdi Masoomian, Robert E. Denroche, William D. Foulkes, John M. S. Bartlett, Chani Stossel, Maria Raitses-Gurevich, Alain Pacis, Ilinca Lungu, Talia Golan, Simeng Bu, Jean Monlong, T. Cabrera, George Zogopoulos, Celine Domecq, Spring Holter, Jin Yong Patrick Park, Jamil Asselah, Adeline Cuggia
Publikováno v:
WAng, Y, Patrick Park, J Y, Pacis, A, E. Denroche, R, Jang, G H, Zhang, A, Cuggia, A, Domecq, C, Monlong, J, Raitses-Gurevich, M, C. Grant, R, Borgida, A, Holter, S, Stossel, C, Bu, S, Masoomian, M, Lungu, I, Bartlett, J, M. Wilson, J, Gao, Z-H, Riazalhosseini, Y, Asselah, J, Bouganim, N, Cabrera, T, Boucher, L-M, Valenti, D, Biagi, J, M.T Greenwood, C, Polak, P, D. Foulkes, W, Golan, T, M. O'Kane, G, E. Fischer, S, J. Knox, J, Gallinger, S & Zogopoulos, G 2020, ' A preclinical trial and molecularly-annotated patient cohort identify predictive biomarkers in homologous recombination deficient pancreatic cancer ', Clinical Cancer Research . https://doi.org/10.1158/1078-0432.CCR-20-1439
Purpose:Pancreatic ductal adenocarcinoma (PDAC) arising in patients with a germline BRCA1 or BRCA2 (gBRCA) mutation may be sensitive to platinum and PARP inhibitors (PARPi). However, treatment stratification based on gBRCA mutational status alone is
Autor:
Sachin K. Khiste, Mohammad Burhan Uddin, Ronald A. Hill, Sami Nazzal, Zhijun Liu, Xin Gu, Salman B. Hosain, Kartik R. Roy, Yong-Yu Liu
Publikováno v:
Mol Cancer Ther
Ceramide (Cer) is an active cellular sphingolipid that can induce apoptosis or proliferation-arrest of cancer cells. Nanoparticle-based delivery offers an effective approach for overcoming bioavailability and biopharmaceutics issues attributable to t
Autor:
Jamie J. Shah, Francis Y. Lee, Bruce S. Fischer, Hossein Khiabanian, Sharon R. Pine, Joseph R. Bertino, Katherine M. Morgan, Amartya Singh, Jeffrey A. Rosenfeld
Publikováno v:
Molecular Cancer Therapeutics. 16:2759-2769
Notch signaling is aberrantly activated in approximately one third of non–small cell lung cancers (NSCLC). We characterized the interaction between BMS-906024, a clinically relevant Notch gamma secretase inhibitor, and front-line chemotherapy in pr
Autor:
Dan L. Sackett, Alex Kagansky, Susan E. Bates, Jung-Hyun Kim, Jane B. Trepel, Nicholas C.O. Lee, Hee-Sheung Lee, Yves Pommier, Natalay Kouprina, Vladimir Larionov
Publikováno v:
Cancer Research. 76:902-911
Whole chromosomal instability (CIN), manifested as unequal chromosome distribution during cell division, is a distinguishing feature of most cancer types. CIN is generally considered to drive tumorigenesis, but a threshold level exists whereby furthe
Autor:
Cari Nicholas, Vineeth Sukrithan, Joseph Locker, Hongling Zhao, Juntao Zou, Edward L. Schwartz, Yingjiao Xue, Liang Zhu, Niloy J. Iqbal
Publikováno v:
Cancer Research. 80:1060-1060
The identification of driver mutations and their corresponding targeted drugs has led to significant improvements in the treatment of non-small cell lung cancer (NSCLC) and other solid tumors; however, similar advances have not been made in the treat
Publikováno v:
Molecular Cancer Therapeutics. 8:2015-2026
Anticancer therapy with cisplatin and oxaliplatin is limited by toxicity and onset of tumor resistance. Both drugs form platinum-DNA cross-linked adducts, and cisplatin causes oxidative DNA damage including the 7,8-dihydro-8-oxo-2′-deoxyguanosine (
Publikováno v:
Cancer Research. 64:3391-3394
Mismatch repair (MMR) deficiency was reported to increase resistance of mammalian cells to killing by several genotoxic substances. However, although MMR-deficient cells are ∼100-fold more resistant to killing by SN1 type methylating agents than MM
Publikováno v:
Cancer Research. 75:B1-02
The purpose of this study is to correlate genetic mutations, amino-acid variants, signaling pathways with platiunum based drug activity to shed light on personalized treatment of cancer. Platinum anticancer drugs such as cisplatin, carboplatin, and o
Publikováno v:
Cancer Research. 77:1429-1429
Non-small cell lung cancer (NSCLC) treatment usually involves surgery and chemotherapy with tyrosine kinase inhibitors (TKI) in patients with EGFR mutations (10-15% in Western population, 40% in Asian populations) or with platinum-based regimens. Res
Autor:
Glenn McCluggage, Nuala McCabe, Alistair R.W. Williams, Niamh McGivern, Caroline O. Michie, Laura Hill, Andrena McGavigan, Michael Churchman, Charlie Gourley, Richard D. Kennedy, Karen Keating, Eamonn J. O'Brien, Denis Paul Harkin, Timothy Davison
Publikováno v:
Cancer Research. 76:453-453
Introduction We have previously defined 3 molecular subgroups of High grade serous ovarian cancer (HGSOC), ‘Angio’, ‘Immune’ and ‘Angio_immune’ subgroups using gene expression data from 265 FFPE HGSOC samples obtained from treatment naive