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Reciprocal and Autonomous Glucocorticoid and Androgen Receptor Activation in Salivary Duct Carcinoma
Publikováno v:
Clin Cancer Res
Purpose: To determine the expression of glucocorticoid receptor (GR) and androgen receptor (AR) in salivary duct carcinoma (SDC) and to analyze the role of these proteins in the development and management of this disease entity. Experimental Design:
Autor:
Takashi Kojima, Masahiro Yasunaga, Kenji Hirotani, Yasutoshi Kuboki, Toshihiko Doi, Takashi Kagari, Yoshikatsu Koga, Naoyuki Maeda, Yasuhiro Matsumura, Mayumi Yamauchi, Shigehiro Koganemaru
Publikováno v:
Molecular Cancer Therapeutics. 18:2043-2050
HER3 is overexpressed in several cancers, including colorectal cancer. Although therapies with anti-HER3 antibodies have been investigated, significant clinical benefits have not been reported. U3-1402 is a novel HER3-antibody–drug conjugate (ADC)
Autor:
Tong Zhang, Gayatri Gowrishankar, Aileen Hoehne, Sanjiv S. Gambhir, Oliver D. K. Maddocks, Patrick McCormick, Erik Årstad, Adam J. Shuhendler, Mathias Berndt, Hannah E. Greenwood, Timothy H. Witney, Matthias Glaser, David Y. Lewis, Norman Koglin, Thibault Gendron, Kerstin Sander, Mark F. Lythgoe
Publikováno v:
McCormick, P, Greenwood, H E, Glaser, M, Maddocks, O D K, Gendron, T, Sander, K, Gowrishankar, G, Hoehne, A, Zhang, T, Shuhendler, A J, Lewis, D Y, Berndt, M, Koglin, N, Lythgoe, M, Gambhir, S S, Arstad, E & Witney, T 2019, ' Assessment of tumor redox status through (S)-4-(3-[ 18 F]fluoropropyl)-L-glutamic acid PET imaging of system x c activity ', Cancer Research, vol. 79, no. 4, 79, pp. 853-863 . https://doi.org/10.1158/0008-5472.CAN-18-2634
The cell's endogenous antioxidant system is vital to maintain redox homeostasis. Despite its central role in normal and pathophysiology, no noninvasive tools exist to measure this system in patients. The cystine/glutamate antiporter system xc− main
Autor:
Raghu Kalluri, Valerie S. LeBleu, Yingqi Teng, Hans Petter Eikesdal, Julienne L. Carstens, Hikaru Sugimoto, Lisa M. Becker, Keizo Kanasaki, Akane Kizu
Publikováno v:
Molecular Cancer Research. 16:1568-1578
Deregulated transforming growth factor-β (TGFβ) signaling is a common feature of many epithelial cancers. Deletion of TGFβ receptor type 2 (TGFBR2) in fibroblast specific protein-1 (FSP1)-positive stromal cells induces squamous cell carcinoma in t
Autor:
Jamie J. Shah, Francis Y. Lee, Bruce S. Fischer, Hossein Khiabanian, Sharon R. Pine, Joseph R. Bertino, Katherine M. Morgan, Amartya Singh, Jeffrey A. Rosenfeld
Publikováno v:
Molecular Cancer Therapeutics. 16:2759-2769
Notch signaling is aberrantly activated in approximately one third of non–small cell lung cancers (NSCLC). We characterized the interaction between BMS-906024, a clinically relevant Notch gamma secretase inhibitor, and front-line chemotherapy in pr
Autor:
Levi Sokol, Kim M. Hirshfield, Chandrika Jeyamohan, Srilatha Simhadri, Janice M. Mehnert, Lorna Rodriguez-Rodriguez, Husam Al-Hraishawi, Shridar Ganesan, Sharon R. Pine, Atul Kulkarni, Suzie Chen, Man Lung Teo, Eileen White, Siraj M. Ali
Publikováno v:
Clinical Cancer Research. 23:5631-5638
Purpose: Many patients with BRAFV600E mutant melanoma treated with BRAF inhibitors experience a rapid response, but ultimately develop resistance. Insight into the mechanism of resistance is critical for development of more effective treatment strate
Autor:
Roxanne Diaz, Thangavel Saravanan, Saud Azam, Tariq Masoodi, Sandeep Kumar Parvathareddy, Khawla S. Al-Kuraya, Poyil Pratheeshkumar, Rafia Begum, Khadija A.S. Al-Obaisi, Sasidharan Padmaja Divya, Sarah Siraj, Zeeshan Qadri, Abdul K. Siraj
Publikováno v:
Cancer Research. 81:3192-3192
Background: PD-L1 inhibition is a promising therapeutic target whose efficacy has been demonstrated in several cancers. This study was conducted to evaluate the prognostic significance of PD-L1 expression in a large cohort of Middle Eastern PTC patie
Publikováno v:
Clinical Cancer Research. 23:3884-3895
Purpose: Human papillomavirus 16 (HPV-16) is an important risk factor in head and neck cancer (HNC). Studies suggest that miRNAs play an important role in cancer; however, their role in HPV-mediated oncogenesis remains largely unknown. We investigate
Autor:
Yu Shyr, Li-Ching Huang, Charalambos C. Solomides, Yunguang Sun, Adam P. Dicker, Yong Antican Wang, Joshua D. Palmer, Bo Lu
Publikováno v:
Molecular Cancer Research. 15:896-904
Insulin-like growth factor binding protein 3 (IGFBP3) modulates cell growth through IGF-dependent and -independent mechanisms. Reports suggest that the serum levels of IGFBP3 are associated with various cancers and that IGFBP3 expression is significa
Publikováno v:
Cancer Research. 80:1285-1285
[Introduction] Ovarian cancer is one of the most lethal gynecologic malignancies. More than half of the patients are diagnosed in advanced stages of disease where the prognosis is poor due to the inevitable acquired resistance to platinum agents. Alt