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Autor:
Chen Wang, Rugang Zhang, Ronny Drapkin, Benjamin G. Bitler, Dajiang Guo, Jianhuang Lin, Heng Liu, Iris Müller, Wei Zhou, Andrew V. Kossenkov, Kristian Helin
Publikováno v:
Cancer Immunol Res
The tumor immune microenvironment is influenced by the epigenetic landscape of the tumor. Here, we have identified the SETDB1–TRIM28 complex as a critical suppressor of antitumor immunity. An epigenetic CRISPR–Cas9 screen of 1,218 chromatin regul
Autor:
Ladislav Merta, Natalia Torrealba, Jaroslav Truksa, Jan Stursa, Jiri Neuzil, Lukas Werner, Daniel Rösel, Veronika Tomkova, Kristyna Blazkova, Jan Brábek, Sandra Lettlova, Sukanya Balkrishna Jadhav, Miroslava Kari Adamcová, Cristian Sandoval-Acuña
Publikováno v:
Cancer Research. 81:2289-2303
Deferoxamine (DFO) represents a widely used iron chelator for the treatment of iron overload. Here we describe the use of mitochondrially targeted deferoxamine (mitoDFO) as a novel approach to preferentially target cancer cells. The agent showed mark
Autor:
Dohoon Kim, Jenny Janusis, Michael J. Lee, Jose Mercado-Matos, Fayola Levine, Anne E. Carlisle, Asia N. Matthew-Onabanjo, Leslie M. Shaw, Peter Cruz-Gordillo, Ryan Richards
Publikováno v:
Cancer Res
Beclin 1 has nonautophagic functions that include its ability to regulate endocytic receptor trafficking. However, the contribution of this function to tumor suppression is poorly understood. Here, we provide in vivo evidence that Beclin 1 suppresses
Autor:
Vladislav Korobeynikov, Hanqing Liu, Alexander Y. Deneka, Jeffrey R. Peterson, Petr Makhov, Anna A. Kiseleva, Margret B. Einarson, Peishan Zhang, Anna S. Nikonova, Erica A. Golemis, Ilya G. Serebriiskii
Publikováno v:
Clin Cancer Res
Purpose: For many tumors, signaling exchanges between cancer cells and other cells in their microenvironment influence overall tumor signaling. Some of these exchanges depend on expression of the primary cilium on nontransformed cell populations, as
Publikováno v:
Cancer research, vol 79, iss 4
Rbm38 is a p53 target and an RNA-binding protein known to suppress p53 translation by preventing eukaryotic translation initiation factor 4E (eIF4E) from binding to p53 mRNA. In this study, we show that synthetic peptides corresponding to the binding
Autor:
Bernd Kaina, Dorthe Aasland, Emelie Ellen Reuber, Simon Schneider, Nancy Berte, Markus Christmann, Laura Hauck, Jessica Meyer, Laura Götzinger, Wynand P. Roos, Maja T. Tomicic, Melanie Effenberger
Publikováno v:
Cancer Research. 79:99-113
The DNA-methylating drug temozolomide, which induces cell death through apoptosis, is used for the treatment of malignant glioma. Here, we investigate the mechanisms underlying the ability of temozolomide to induce senescence in glioblastoma cells. T
Publikováno v:
Molecular Cancer Research. 14:753-763
Inhibition of hypoxia-induced stress signaling through JNK potentiates the effects of oxaliplatin. The JNK pathway plays a role in both autophagy and apoptosis; therefore, it was determined how much of the effect of JNK inhibition on oxaliplatin sens
Autor:
Sharon Shacham, Dilara McCauley, Andrzej Jakubowiak, Anoop Mayampurath, Malathi Kandarpa, Dominik Dytfeld, Shaun Rosebeck, Stephanie J Kraftson, Michael Kauffman, Sean P. Maxwell, Jagoda Jasielec, Samuel L. Volchenboum, Mattina Alonge
Publikováno v:
Molecular Cancer Therapeutics. 15:60-71
Exportin1 (XPO1; also known as chromosome maintenance region 1, or CRM1) controls nucleo-cytoplasmic transport of most tumor suppressors and is overexpressed in many cancers, including multiple myeloma, functionally impairing tumor suppressive functi
Autor:
Ming-Rong Chen, Hwei-Jen Lee, Dah-Shyong Yu, Jar-Yi Ho, Tai-Lung Cha, Shih-Ming Huang, Yi-Ta Tsai, Shou-Hung Tang, Yu-Chi Chen, Sun-Yran Chang, Hui Kuan Lin, Sheng-Tang Wu, Victor C. Lin, Pei-Wen Hsiao, Cheng-Ping Yu, Chung-Chih Lin, Mei-Jen Chuang, Guang-Huan Sun
Publikováno v:
Cancer Research. 75:3568-3582
Mitochondria are the powerhouses of cells. Mitochondrial C-Raf is a potential cancer therapeutic target, as it regulates mitochondrial function and is localized to the mitochondria by its N-terminal domain. However, Raf inhibitor monotherapy can indu
Autor:
Elizabeth M. Jaffee, Alexandra B. Pucsek, Todd D. Armstrong, Theodore Kouo, Minwei Cao, Lanqing Huang, Sara Solt
Publikováno v:
Cancer Immunology Research. 3:412-423
Galectin-3 is a 31-kDa lectin that modulates T-cell responses through several mechanisms, including apoptosis, T-cell receptor (TCR) cross-linking, and TCR downregulation. We found that patients with pancreatic ductal adenocarcinoma (PDA) who respond