Zobrazeno 1 - 10
of 15
pro vyhledávání: ''
Autor:
Ladislav Merta, Natalia Torrealba, Jaroslav Truksa, Jan Stursa, Jiri Neuzil, Lukas Werner, Daniel Rösel, Veronika Tomkova, Kristyna Blazkova, Jan Brábek, Sandra Lettlova, Sukanya Balkrishna Jadhav, Miroslava Kari Adamcová, Cristian Sandoval-Acuña
Publikováno v:
Cancer Research. 81:2289-2303
Deferoxamine (DFO) represents a widely used iron chelator for the treatment of iron overload. Here we describe the use of mitochondrially targeted deferoxamine (mitoDFO) as a novel approach to preferentially target cancer cells. The agent showed mark
Autor:
Dohoon Kim, Jenny Janusis, Michael J. Lee, Jose Mercado-Matos, Fayola Levine, Anne E. Carlisle, Asia N. Matthew-Onabanjo, Leslie M. Shaw, Peter Cruz-Gordillo, Ryan Richards
Publikováno v:
Cancer Res
Beclin 1 has nonautophagic functions that include its ability to regulate endocytic receptor trafficking. However, the contribution of this function to tumor suppression is poorly understood. Here, we provide in vivo evidence that Beclin 1 suppresses
Publikováno v:
Molecular Cancer Research. 14:753-763
Inhibition of hypoxia-induced stress signaling through JNK potentiates the effects of oxaliplatin. The JNK pathway plays a role in both autophagy and apoptosis; therefore, it was determined how much of the effect of JNK inhibition on oxaliplatin sens
Autor:
Lydia Schneider, Leoni A. Kunz-Schughart, Claudia Förster, Daniel Zips, Nils Cordes, Iris Eke
Publikováno v:
Cancer Research 73(2013)1, 297-306
EGF receptor (EGFR) promotes tumor growth as well as radio- and chemoresistance in various human malignancies including squamous cell carcinomas (SCC). In addition to deactivation of prosurvival signaling, cetuximab-mediated EGFR targeting might conc
Autor:
Francesco Di Virgilio
Publikováno v:
Cancer Research. 72:5441-5447
Purines were long thought to be restricted to the intracellular compartment, where they are used for energy transactions, nucleic acid synthesis, and a multiplicity of biochemical reactions. However, it is now clear that both adenosine and adenosine
Autor:
Steven Le Gouill, Anne Moreau, Linda Bodet, Cyrille Touzeau, Philippe Moreau, Christelle Dousset, Patricia Gomez-Bougie, Catherine Pellat-Deceunynck, Stéphanie Bonnaud, Martine Amiot
Publikováno v:
Clinical Cancer Research. 17:5973-5981
Purpose: Mantle cell lymphoma (MCL) is considered to be incurable. ABT-737 is a BH3 mimetic that targets Bcl-2, which is overexpressed in MCL and implicated in drug resistance. The present work investigated the antitumor effect of ABT-737. Experiment
Autor:
Daniela Coltrini, Stefano Indraccolo, Roberto Ronca, Giorgia Nardo, Patrizia Alessi, Daria Leali, Michela Corsini, Marco Presta
Publikováno v:
Molecular Cancer Therapeutics. 10:1600-1610
Fibroblast growth factor-8b (FGF8b) exerts nonredundant autocrine/paracrine functions in steroid hormone–regulated tumors. Previous observations had shown that the soluble pattern recognition receptor long pentraxin-3 (PTX3) is a natural selective
Autor:
Uhi Toh, Masayoshi Kage, Teruhiko Fujii, Naoko Seki, Kazuo Shirouzu, Yoshito Akagi, Motoshi Miyagi, Jingo Kusukawa, Thomas J. Sayers, Hideaki Yamana
Publikováno v:
Molecular Cancer Therapeutics. 9:1842-1851
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive human cancers, and novel treatment modalities are required. We investigated the therapeutic potential of the tumor necrosis factor–related apoptosis-inducing ligand (TRAIL/Apo2
Autor:
Yun-Wei Lin, Jhih-Yuan Jhan, Chia-Che Chang, Jen-Chung Ko, Shih-Ci Ciou, Ying-Jhen Su, Show-Mei Chuang, Chao-Min Cheng, Szu-Ting Lin
Publikováno v:
Molecular Cancer Research. 7:1378-1389
Erlotinib (Tarceva) is a selective epidermal growth factor receptor tyrosine kinase inhibitor in the treatment of human non–small cell lung cancer (NSCLC). In this study, we investigated the roles of ERK1/2 and AKT signaling pathways in regulating
Publikováno v:
Cancer Research. 69:4327-4334
Induction of a functional CD8+ T-cell response is the important criterion for cancer vaccines, and it is unclear whether acute or chronic live vectors are better suited for cancer antigen delivery. We have evaluated the tumor protective ability of tw