Zobrazeno 21 - 30
of 151
pro vyhledávání: ''
Autor:
Davide Ciardiello, N. Zanaletti, Pietro Paolo Vitiello, Nunzia Matrone, Claudia Cardone, C. Borrelli, Valentina Belli, Teresa Troiani, P. Vitale, Giulia Martini, Fortunato Ciardiello, Davide Melisi, L. Poliero, Erika Martinelli
Publikováno v:
Cancer Research. 79:295-295
DNA damage response (DDR) is crucial in a variety of tumors and several new drugs that interfere with this mechanism are already available or in advanced clinical testing. RAS-MAPK pathway activation, induced by either RAS or BRAF mutation, is a freq
Autor:
Dong-Jun Bae, Joo-Yun Byun, Sang-Yeob Kim, Young-Gil Ahn, Kwee Hyun Suh, InHwan Bae, Young Hoon Kim
Publikováno v:
Cancer Research. 79:1305-1305
The mitogen-activated protein kinase (MAPK) pathway plays an important role for the survival and proliferation of tumor cells. For example, the activation of the MAPK pathway due to mutations in BRAF, NRAS and KRAS kinases is known to be the causes o
Publikováno v:
Cancer Research. 79:70-70
Reactive oxygen species (ROS) are constantly generated in mitochondria as a consequence of normal cellular metabolic reactions and play vital roles in cell signaling and homeostasis. Prolong production of elevated levels of ROS may lead to oxidative
Autor:
Fong Chun Chan, Alina S. Gerrie, Tomohiro Aoki, Hennady P. Shulha, Kerry J. Savage, Marcel B. Bally, Anja Mottok, Robert Kridel, Pedro Farinha, Sara Mostafavi, Saeed Saberi, Marco A. Marra, Ali Bashashati, Barbara Meissner, Elena Vigano, Christoffer Hother, Daisuke Ennishi, Allen Zhang, Laurie H. Sehn, Michael R. Gold, Andrew P. Weng, Daniel Lai, Andrew J. Mungall, Sohrab P. Shah, Lauren Chong, Ulrich Steidl, Diego Villa, Ryan D. Morin, Christian Steidl, Sohrab Salehi, Libin Abraham, Bruce Woolcock, Susana Ben-Neriah, Merrill Boyle, Katsuyoshi Takata, Randy D. Gascoyne, Gabriela V. Cohen Freue, David W. Scott, Graham W. Slack, Shannon Healy, Joseph M. Connors, Adele Telenius, Derek S. Chiu
Publikováno v:
Cancer Research. 79:3480-3480
Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma subtype worldwide, accounting for 40% of all non-Hodgkin lymphomas. DLBCL presents as an aggressive disease requiring immediate treatment. Although significant improvement in outcome h
Autor:
Ahmed Ihmaid, Qutayba Hamid, Maha Saber-Ayad, Rakhee K. Ramakrishnan, Abdulla Alalool, Khuloud Bajbouj, Reem Abdullah, Suhaib Al Haj Ali
Publikováno v:
Cancer Research. 79:4711-4711
Background: Lung cancer is the most common cancer globally, with an estimate of more than 2 million new cases every year. Protein arginine methyltransferase 5 (PRMT5) is an enzyme that is identified to be involved in multiple cellular events, includi
Autor:
Eileen Fung, Kostyantyn Krysan, Jay M. Lee, Manash K. Paul, W. Dean Wallace, David Elashoff, Steven M. Dubinett, Michael C. Fishbein, Jane Yanagawa, Mi-Heon Lee, Rong Guo, John D. Minna
Publikováno v:
Clinical Cancer Research. 24:B20-B20
Background: Interferon-gamma (IFN-g) is known to play a pivotal role in PD-L1 expression and immune evasion in cancer cells, but there is little known regarding its interactions with premalignant lung lesions. Methods: Immortalized human bronchial ep
Autor:
Larry G. Thaete, Viqar Syed, Thomas P. Conrads, Guisong Wang, Pang-ning Teng, Gustavo C. Rodriguez, Brian L. Hood, Chad A. Hamilton, Jane Turbov, Huyen Nguyen, Leyla Kavandi, Laura R. Lee, George L. Maxwell
Publikováno v:
Cancer Prevention Research. 6:731-743
Human studies suggest that progesterone and calcitriol may prove beneficial in preventing or inhibiting oncogenesis, but the underlying mechanism is not fully understood. The current study investigates the effects of progesterone, calcitriol, and the
Publikováno v:
Clinical Cancer Research. 18:4691-4701
Purpose: Histone deacetylase inhibitors (HDACi) are actively explored as new-generation epigenetic drugs but have low efficacy in cancer monotherapy. To reveal new mechanism for combination therapy, we show that HDACi induce cell death but simultaneo
Autor:
Kiminobu Arima, Yoshiki Sugimura, Yoichi Iwamoto, Kenichiro Ishii, Hideki Kanda, Yasuhide Hori, Hideaki Kise, Norihito Soga, Kohei Nishikawa
Publikováno v:
Cancer Prevention Research. 4:87-96
In prostate cancer, tumor–stroma interactions play a critical role in the promotion of tumorigenesis, and thus the prevention of those interactions is a promising target to suppress tumor growth. Several studies demonstrated that alpha1-adrenocepto
Autor:
Wei-Ting Chao, Wan-Chen Wei, Ling-Yi Kao, Shih-Hsien Chuang, Hsiang-Ling Chiu, Yi-Che Wu, Yuan-Chiang Chung, Sun Wei-Ting
Publikováno v:
Cancer Research. 78:3729-3729
Epidermal growth factor receptor (EGFR) is the key receptor for cancer cell growing, cetuximab is the monoclonal antibody that targets EGFR and was approved for treatment of colorectal, head and neck cancer. However, patients with KRAS /BRAF mutation