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Autor:
Ladislav Merta, Natalia Torrealba, Jaroslav Truksa, Jan Stursa, Jiri Neuzil, Lukas Werner, Daniel Rösel, Veronika Tomkova, Kristyna Blazkova, Jan Brábek, Sandra Lettlova, Sukanya Balkrishna Jadhav, Miroslava Kari Adamcová, Cristian Sandoval-Acuña
Publikováno v:
Cancer Research. 81:2289-2303
Deferoxamine (DFO) represents a widely used iron chelator for the treatment of iron overload. Here we describe the use of mitochondrially targeted deferoxamine (mitoDFO) as a novel approach to preferentially target cancer cells. The agent showed mark
Autor:
Vladislav Korobeynikov, Hanqing Liu, Alexander Y. Deneka, Jeffrey R. Peterson, Petr Makhov, Anna A. Kiseleva, Margret B. Einarson, Peishan Zhang, Anna S. Nikonova, Erica A. Golemis, Ilya G. Serebriiskii
Publikováno v:
Clin Cancer Res
Purpose: For many tumors, signaling exchanges between cancer cells and other cells in their microenvironment influence overall tumor signaling. Some of these exchanges depend on expression of the primary cilium on nontransformed cell populations, as
Autor:
Ming-Rong Chen, Hwei-Jen Lee, Dah-Shyong Yu, Jar-Yi Ho, Tai-Lung Cha, Shih-Ming Huang, Yi-Ta Tsai, Shou-Hung Tang, Yu-Chi Chen, Sun-Yran Chang, Hui Kuan Lin, Sheng-Tang Wu, Victor C. Lin, Pei-Wen Hsiao, Cheng-Ping Yu, Chung-Chih Lin, Mei-Jen Chuang, Guang-Huan Sun
Publikováno v:
Cancer Research. 75:3568-3582
Mitochondria are the powerhouses of cells. Mitochondrial C-Raf is a potential cancer therapeutic target, as it regulates mitochondrial function and is localized to the mitochondria by its N-terminal domain. However, Raf inhibitor monotherapy can indu
Autor:
Nathalie Bonnefoy, Armand Bensussan, Nicole Bec, Jérémy Bastid, Stéphanie Cochaud, Caroline Laheurte, Jean-François Eliaou, Cécile Dejou, Laurent Gros, Anne Regairaz, Jérôme Giustiniani, Christian Larroque, Patrice Hemon, Emilie Laprevotte, Gilles Alberici, Elisa Funck-Brentano
Publikováno v:
Cancer Immunology Research
Cancer Immunology Research, American Association for Cancer Research, 2015, 3 (3), pp.254-265. ⟨10.1158/2326-6066.CIR-14-0018⟩
Cancer Immunology Research, American Association for Cancer Research, 2015, 3 (3), pp.254-265. ⟨10.1158/2326-6066.CIR-14-0018⟩
The ectonucleotidases CD39 and CD73 hydrolyze extracellular adenosine triphosphate (ATP) and adenosine diphosphate (ADP) to generate adenosine, which binds to adenosine receptors and inhibits T-cell and natural killer (NK)–cell responses, thereby s
Autor:
Peter J. Houghton, Axel Vater, Janina Ratajczak, Magdalena Alicja Maj, Gabriela Schneider, Maciej Tarnowski, Ahmed Abdel-Latif, Yuri M. Klyachkin, Ewa Bryndza, Mariusz Z. Ratajczak, Magdalena Kucia, Sven Klussmann, Andrew J. Morris
Publikováno v:
Molecular Cancer Research. 11:793-807
Evidence suggests that bioactive lipids may regulate pathophysiologic functions such as cancer cell metastasis. Therefore, we determined that the bioactive lipid chemoattractants sphingosine-1-phosphate (S1P) and ceramide-1-phosphate (C1P) strongly e
Autor:
Lydia Schneider, Leoni A. Kunz-Schughart, Claudia Förster, Daniel Zips, Nils Cordes, Iris Eke
Publikováno v:
Cancer Research 73(2013)1, 297-306
EGF receptor (EGFR) promotes tumor growth as well as radio- and chemoresistance in various human malignancies including squamous cell carcinomas (SCC). In addition to deactivation of prosurvival signaling, cetuximab-mediated EGFR targeting might conc
Autor:
Eric Lam, Chuay-Yeng Koo, Ana R. Gomes, Rosa Aligué, Paola H. Pinto, Natalia de Olano, Lara J. Monteiro
Publikováno v:
Molecular Cancer Research. 10:1189-1202
E2F1 is responsible for the regulation of FOXM1 expression, which plays a key role in epirubicin resistance. Here, we examined the role and regulation of E2F1 in response to epirubicin in cancer cells. We first showed that E2F1 plays a key role in pr
Publikováno v:
Cancer Research. 70:5870-5879
We sought to examine the effects of microtubule-targeting agents (MTA) on neural cells to better understand the problem of neurotoxicity, their principal side effect, and to possibly develop a model of clinical toxicity. Studies showed that microtubu
Autor:
Asami Sakamoto, Takashi Tsuruo, Kazuo Shin-ya, Akihiro Tomida, Hae Ryong Park, Aki Furuno, Junko Sakurai, Sakae Saito
Publikováno v:
Cancer Research. 69:4225-4234
Glucose deprivation, a cell condition that occurs in solid tumors, activates the unfolded protein response (UPR). A key feature of the UPR is the transcription program activation, which allows the cell to survive under stress conditions. Here, we sho
Autor:
Adorjan Aszalos, Jun-Jie Yin, Ding Wu Shen, Michael M. Gottesman, Toren Finkel, Xing-Jie Liang
Publikováno v:
Molecular Cancer Research. 6:1499-1506
Tumors frequently develop resistance to cisplatin, a platinum drug used as a cornerstone of present-day chemotherapy regimens, significantly decreasing its usefulness in the clinic. Although it is known that cisplatin-resistant (CP-r) cancer cells co