Zobrazeno 1 - 10
of 90
pro vyhledávání: '"35"'
Autor:
Kiyoko Oshima, Stephen S. Hecht, Chieh Ti Kuo, Jo Hsin Chen, Steven G. Carmella, Noah P. Zimmerman, Gary D. Stoner, Li-Shu Wang, Jibran Siddiqui, Daniel S. Peiffer, Benjamin W. S. Ransom, Yi-Wen Huang
Publikováno v:
Cancer Prevention Research. 7:574-584
Diets containing either freeze-dried black raspberries (BRBs) or their polyphenolic anthocyanins (ACs) have been shown to inhibit the development of N-nitrosomethylbenzylamine (NMBA)–induced esophageal cancer in rats. The present study was conducte
Autor:
R Yelensky, Phillip J. Stephens, Jie He, Kristina W. Brennan, Mirna Jarosz, Maureen T. Cronin, V.A. Miller, Doron Lipson, Christine E. Sheehan, J.S. Ross
Publikováno v:
Cancer Research. 72:PD02-07
Background: As more therapies targeting genomic alterations become available, next-generation sequencing (NGS) is increasingly performed in tumor types where mutational status may drive treatment choice. In addition to its ability to identify base su
Publikováno v:
Molecular Cancer Therapeutics. 17:B088-B088
Purpose: Gain-of-function mutations of KIT are pathognomonic in the majority of sporadic gastrointestinal stromal tumors (GISTs). Several micro-RNAs have been shown to be dysregulated in GISTs and impact KIT expression levels. Little is known, though
Autor:
Michael Pawlita, Gary M. Clifford, Rolando Herrero, Pierre Hainaut, Min Dai, Xavier Castellsagué, Silvia Franceschi, Florence Le Calvez, Peter J.F. Snijders
Publikováno v:
Cancer Research. 64:468-471
TP53 mutations were analyzed in 35 human papillomavirus (HPV) type 16 DNA-positive cancers of the oral cavity and oropharynx and in 35 HPV DNA-negative cancers matched by subsite, country, sex, age, and tobacco and alcohol consumption. Wild-type TP53
Autor:
Shelly Seward, Brian L. Abbott, Zoran Gatalica, Joanne Xiu, Sandeep K. Reddy, Ryan Bender, Mohamed E. Salem
Publikováno v:
Cancer Research. 76:2750-2750
Homologous recombination (HR) is important in DNA double-strand break repair. HR defects promote carcinogenesis and are associated with selective sensitivity to PARP-inhibitors and DNA-damaging agents. We collected 1029 tumor samples in 13 cancer typ
Autor:
Maria Chiara Abbenante, Sarah Parisi, Chiara Sartor, Viviana Guadagnuolo, Francesca Volpato, Antonella Padella, Stefania Paolini, Giovanni Martinelli, Ilaria Iacobucci, Guido Biasco, Anna Maria Ferrari, Emanuela Ottaviani, Michele Cavo, Cristina Papayannidis, Giovanni Marconi, Giorgia Simonetti, Massimo Delledonne, Maria Chiara Fontana
Publikováno v:
Cancer Research. 75:4848-4848
Introduction: In Acute Myeloid Leukemia (AML) there is a strong need to develop new diagnostic and therapeutic options: to identify the genes mostly predictive of treatment response, we use Single Nucleotide Polymorphism (SNP) Arrays and Whole Exome
Autor:
Yuchen Jiao, Krishnendu Chatterjee, Alvin Makohon-Moore, Fay Wong, Christine A. Iacobuzio-Donahue, Johannes G. Reiter, Martin A. Nowak, Ming Zhang, Bert Vogelstein, Ivana Bozic, Nickolas Papadopoulos, Kenneth W. Kinzler
Publikováno v:
Cancer Research. 75:4137-4137
INTRO: Pancreatic adenocarcinoma (PDAC) patients are often diagnosed with metastatic disease, yet the extent to which metastasis is determined by genetic evolution is unknown. A better understanding of this lethal process would have great clinical si
Autor:
Adriana Heguy, Kevin P. Lui, Anna C. Pavlick, Eleazar C. Vega-Saenz de Miera, Naima Ismaili, Richard L. Shapiro, Iman Osman, Chaowei Wu, Amel Salhi, Judy Zhong, Ines Pires da Silva, Russell S. Berman
Publikováno v:
Cancer Research. 75:A35-A35
Background: Molecularly targeted therapy is improving response rates and overall survival in subsets of melanoma patients. However, targeted therapy for triple negative patients (BRAF, NRAS and c-KIT wild type) is not yet defined. In addition, new ev
Autor:
Ulrike Zabel, Martin Fassnacht, Andrea Osswald, Marthe Rizk-Rabbin, Thomas Schwarzmayr, Anett Schmittfull, Thomas Meitinger, Caroline Kisker, Martin Reincke, Antonella Forlino, Katrin Schaak, Orsetta Zuffardi, Constantine A. Stratakis, Cristina L Ronchi, Delphine Vezzosi, Silviu Sbiera, Felix Beuschlei, Guilaume Assie, Davide Calebiro, Eva Szarek, Olivia Barreau, Paraskevi Salpea, Thomas Wieland, Martin J. Lohse, Susanne Diener, Annalisa Vetro, Bruno Allolio, Fabio R. Faucz, Tim M. Strom, Jérôme Bertherat
Publikováno v:
Cancer Research. 74:LB-182
Corticotropin-independent Cushing's syndrome may be caused by tumors or hyperplasia of the adrenal cortex. Until now genetic alterations explain only a small fraction of cases. The observation that a subset of adrenal adenomas is characterized by abn
Publikováno v:
Cancer Research. 74:336-336
Introduction: Statins trigger apoptosis in tumour cells in vitro and, particularly, melanoma cells are susceptible to statin induced apoptosis. Growth of normal melanocytes and early stage melanoma can be inhibited by IL-6, whereas metastatic melanom