Zobrazeno 1 - 10
of 32
pro vyhledávání: '"35"'
Autor:
Michael Pawlita, Gary M. Clifford, Rolando Herrero, Pierre Hainaut, Min Dai, Xavier Castellsagué, Silvia Franceschi, Florence Le Calvez, Peter J.F. Snijders
Publikováno v:
Cancer Research. 64:468-471
TP53 mutations were analyzed in 35 human papillomavirus (HPV) type 16 DNA-positive cancers of the oral cavity and oropharynx and in 35 HPV DNA-negative cancers matched by subsite, country, sex, age, and tobacco and alcohol consumption. Wild-type TP53
Autor:
Shelly Seward, Brian L. Abbott, Zoran Gatalica, Joanne Xiu, Sandeep K. Reddy, Ryan Bender, Mohamed E. Salem
Publikováno v:
Cancer Research. 76:2750-2750
Homologous recombination (HR) is important in DNA double-strand break repair. HR defects promote carcinogenesis and are associated with selective sensitivity to PARP-inhibitors and DNA-damaging agents. We collected 1029 tumor samples in 13 cancer typ
Autor:
Maria Chiara Abbenante, Sarah Parisi, Chiara Sartor, Viviana Guadagnuolo, Francesca Volpato, Antonella Padella, Stefania Paolini, Giovanni Martinelli, Ilaria Iacobucci, Guido Biasco, Anna Maria Ferrari, Emanuela Ottaviani, Michele Cavo, Cristina Papayannidis, Giovanni Marconi, Giorgia Simonetti, Massimo Delledonne, Maria Chiara Fontana
Publikováno v:
Cancer Research. 75:4848-4848
Introduction: In Acute Myeloid Leukemia (AML) there is a strong need to develop new diagnostic and therapeutic options: to identify the genes mostly predictive of treatment response, we use Single Nucleotide Polymorphism (SNP) Arrays and Whole Exome
Autor:
Ulrike Zabel, Martin Fassnacht, Andrea Osswald, Marthe Rizk-Rabbin, Thomas Schwarzmayr, Anett Schmittfull, Thomas Meitinger, Caroline Kisker, Martin Reincke, Antonella Forlino, Katrin Schaak, Orsetta Zuffardi, Constantine A. Stratakis, Cristina L Ronchi, Delphine Vezzosi, Silviu Sbiera, Felix Beuschlei, Guilaume Assie, Davide Calebiro, Eva Szarek, Olivia Barreau, Paraskevi Salpea, Thomas Wieland, Martin J. Lohse, Susanne Diener, Annalisa Vetro, Bruno Allolio, Fabio R. Faucz, Tim M. Strom, Jérôme Bertherat
Publikováno v:
Cancer Research. 74:LB-182
Corticotropin-independent Cushing's syndrome may be caused by tumors or hyperplasia of the adrenal cortex. Until now genetic alterations explain only a small fraction of cases. The observation that a subset of adrenal adenomas is characterized by abn
Publikováno v:
Cancer Research. 72:1623-1623
Squamous cell carcinoma (SCC) is one of two major types of esophageal cancer. Major etiological factors for this disease include the use of tobacco and alcohol, and the consumption of salt-cured and moldy foods that are frequently contaminated with N
Autor:
Françoise Rothé, C Desmedt, Fedro A. Peccatori, David Venet, Christos Sotiriou, ER Mardis, Hamdy A. Azim, Bastien Nguyen, Giancarlo Pruneri
Publikováno v:
Cancer Research. 78:P2-05
Background Pregnancy is known to modulate breast cancer (BC) risk. Different reproductive behaviors have been shown to impact not only the risk of developing BC but also the phenotypes of these tumors. Breast cancer diagnosed during pregnancy (BCP) i
Autor:
Olwen Hahn, Lisle E. Mose, Dona M. Kanavy, Bradford C. Powell, Sara M. Tolaney, Lisa A. Carey, Donald A. Berry, Charles M. Perou, David Marron, Katherine A. Hoadley, Terry Hyslop, William M. Sikov
Publikováno v:
Cancer Research. 80:P4-05
Background: Triple-negative breast cancer is an aggressive disease with limited treatment options beyond chemotherapy. In CALGB 40603, adding either carboplatin (Cb) or bevacizumab (Bev) to standard neoadjuvant chemotherapy (NACT) increased pathologi
Autor:
Jean-Luc Van Laethem, Brenda B. Tromp, Jessica Vermeulen, Josep Tabernero, Brett Hall, Neil N. Steven, Sally S. Clive, Rajesh Bandekar, Eric Angevin, Thomas A. Puchalski, Isabelle Ray-Coquard, Christian C. Ottensmeier, Jose A. Lopez-Martin, Elena Elez, Luc Dirix, Jean-Pascal Machiels, Razelle Kurzrock, Rastilav Bahleda, Helgi van de Velde, Florence Joly, Steven Cohen, Manjula Reddy
Publikováno v:
Clinical Cancer Research. 20:2192-2204
Purpose: This phase I/II study evaluated safety, efficacy, and pharmacokinetics of escalating, multiple doses of siltuximab, a chimeric anti-interleukin (IL)-6 monoclonal antibody derived from a new Chinese hamster ovary (CHO) cell line in patients w
Autor:
Nataliya Melnyk, Yoke-Eng Chiew, Sally M Hunter, C. Blake Gilks, Teri A. Longacre, Michael S. Anglesio, Kylie L. Gorringe, Raghwa Sharma, David G. Huntsman, Anna deFazio, Ian G. Campbell
Publikováno v:
Clinical Cancer Research. 17:7273-7282
Purpose: Serous ovarian carcinomas are the predominant epithelial ovarian cancer subtype and it has been widely believed that some or all of these may arise from precursors derived from the ovarian surface epithelium or fimbriae, although direct mole
Autor:
Qian Li, Howard C. Crawford, Venkateshwar Madka, Naveena B. Janakiram, Vernon E. Steele, Stan Lightfoot, Misty Ely, Altaf Mohammed, Chinthalapally V. Rao
Publikováno v:
Cancer Prevention Research. 3:1417-1426
Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic malignancy with a dismal prognosis. Developing novel strategies to prevent or delay pancreatic cancer is currently of intense interest. The chemopreventive efficacy of gefitinib, a