Zobrazeno 41 - 50
of 71
pro vyhledávání: '"35"'
Publikováno v:
Molecular Cancer Therapeutics. 14:B22-B22
Introduction: At a global level breast cancer is the second most common cancer, and the most frequent in women. Statins are 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) inhibitors. HMG-CoA reductase is a rate-limiting enzyme in
Autor:
Hideki Furuya, Kayoko Iino, Charles J. Rosser, Toshihiko Kawamori, Paulette M Tamashiro, Yoshiko Shimizu
Publikováno v:
Cancer Research. 75:P6-06
Introduction: The bioactive sphingolipids, ceramide/sphingosine and sphingosine 1-phosphate (S1P) possess opposite effects on cell fate. Sphingosine kinase 1 (SphK1) is an enzyme that principally regulates the balance or the "rheostat" of the sphingo
Publikováno v:
Cancer Research. 74:B51-B51
Introduction: Neuroblastoma (NB) is the most common extracranial solid tumor of infants. We constructed a tissue microarray (TMA) including 47 diagnostic NB cases and performed immunohistochemical (IHC) staining for a number of biomarkers. Differenti
Autor:
Hiroaki Kimura, Yukihiko Hiroshima, Hiroyuki Tsuchiya, Fuminari Uehara, Elena V. Efimova, Robert M. Hoffman, Shinji Miwa, Katsuhiro Hayashi, Shuya Yano, Yasunori Matsumoto, Mako Yamamoto
Publikováno v:
Cancer Research. 74:2384-2384
The DNA damage response protein 53BP1 forming foci when double-stranded breaks occur in DNA. In this study, the response to DNA damage during mitosis was visualized using fluorescent protein-based real-time imaging of 53BP1 linked to GFP (GFP-53BP1)
Publikováno v:
Cancer Research. 74:3185-3185
Primary prevention of human cancers through identification of potential environmental carcinogens is an important goal. Phthalates such as di(2-ethylhexyl)phthalate (DEHP) and di-n-octylphthalate (DOP), the most widely used industrial plasticizers, a
Publikováno v:
Cancer Research. 74:843-843
In T-cell acute lymphoblastic leukemia (ALL), the genes CDKN2A (p16 and p14) and MTAP are homozygously co-deleted, with a frequency of ∼35 %. MTAP cleaves the natural substrate, 5′-deoxy-5′-methylthioadenosine, to adenine and 5-methylthioribose
Autor:
Yongzhao Shao, Cindy Spittle, David Polsky, Jyothi Sakuntala Tadepalli, Anna C. Pavlick, Dawne N. Shelton, Gregory Chang, Iman Osman, Paula Stonemetz, Manohar R. Furtado, Nathaniel H. Fleming, George Karlin-Neumann
Publikováno v:
Cancer Research. 74:2847-2847
Introduction: Our group has been developing methods to quantitatively detect mutant BRAF DNA in the plasma of metastatic melanoma patients, with the aim of developing new biomarker assays. In this study we evaluated the potential of a probe-based, dr
Autor:
Diane Krämer, Daniel Mueller, Christian Beisenherz-Huss, Constance Ketterer, Michael H.G. Kubbutat, Carolin Heidemann-Dinger
Publikováno v:
Cancer Research. 74:5160-5160
The epigenetic regulation of gene expression has been of increasing interest in the last couple of years. It has been shown that methylation of DNA may pass information epigenetically even from one cellular generation to the next without changing the
Autor:
Xiyuan Zhang, Leena Hilakivi-Clarke
Publikováno v:
Cancer Research. 73:B66-B66
We recently found that starting intake of isoflavone genistein (GEN) present in soyfoods at the time when mammary tumors are treated with tamoxifen (TAM) increases de novo resistance to TAM and the risk of recurrence in a new rat model of estrogen re
Publikováno v:
Cancer Research. 73:3432-3432
Background. Gallbladder carcinoma (GBC) is a highly fatal disease with poor prognosis and few therapeutic alternatives. In Chile, it has an extremely high incidence and is the second cause of death by cancer among women. Heat shock protein 90 (HSP90)