Zobrazeno 1 - 10
of 11
pro vyhledávání: ''
Autor:
Jinying Shen, Yujie Zhao, Linhai Zhong, Tianhui Hu, Xiong Chen, Xiaolin Xu, Daxuan Wang, Yan-yan Zhan, Xiaoting Hong, Hanwei Cao, Yitong Zhou, Jianben Wu, Ying Lin, Wenqing Zhang, Jihuan Hou
Publikováno v:
Cancer Research. 81:5904-5918
Invasive mucinous lung adenocarcinoma (IMA) is a subtype of lung adenocarcinoma with a strong invasive ability. IMA frequently carries "undruggable" KRAS mutations, highlighting the need for new molecular targets and therapies. Nuclear receptor HNF4
Autor:
Sachin K. Khiste, Mohammad Burhan Uddin, Ronald A. Hill, Sami Nazzal, Zhijun Liu, Xin Gu, Salman B. Hosain, Kartik R. Roy, Yong-Yu Liu
Publikováno v:
Mol Cancer Ther
Ceramide (Cer) is an active cellular sphingolipid that can induce apoptosis or proliferation-arrest of cancer cells. Nanoparticle-based delivery offers an effective approach for overcoming bioavailability and biopharmaceutics issues attributable to t
Autor:
Max M. Quinn, Xiaoen Wang, Cyril H. Benes, Ashley A. Merlino, Qingsong Liu, Yuyang Li, Peng Gao, Kwok-Kin Wong, Nathanael S. Gray, Feiyang Liu, Fei Li, Yan Liu
Publikováno v:
Cancer Research. 77:5068-5076
Cells lacking the tumor suppressor gene LKB1/STK11 alter their metabolism to match the demands of accelerated growth, leaving them highly vulnerable to stress. However, targeted therapy for LKB1-deficient cancers has yet to be reported. In both Kras/
Autor:
Sam S. Yoon, Deirdre Jill Cohen, Benjamin Schmidt, Do Joong Park, Chang Hwan Yoon, Teresa S. Kim, Yelena Y. Janjigian, Hae-June Lee, Nicholas J. Thomas
Publikováno v:
Clinical Cancer Research. 20:3974-3988
Purpose: Gastric cancers may harbor a subset of cells with cancer stem cell (CSC) properties, including chemotherapy resistance, and CD44 is a gastric CSC marker. The Hedgehog (HH) pathway is a key developmental pathway that can be subverted by CSCs
Autor:
Alice C. Fan, Hua Fan-Minogue, Sanjiv S. Gambhir, Ramasamy Paulmurugan, Dean W. Felsher, Sandhya Bodapati, Tarik F. Massoud, David E. Solow-Cordero
Publikováno v:
Molecular Cancer Therapeutics. 12:1896-1905
Deregulation of c-Myc plays a central role in the tumorigenesis of many human cancers. Yet, the development of drugs regulating c-Myc activity has been challenging. To facilitate the identification of c-Myc inhibitors, we developed a molecular imagin
Autor:
John J. Tentler, Natalie J. Serkova, John J. Arcaroli, Amy M. Brown, Aik Choon Tan, Fortunato Ciardiello, M. Pia Morelli, Sujatha Nallapareddy, Erica L. Bradshaw-Pierce, Todd M. Pitts, Manuel Hidalgo, Gillian N. Kulikowski, S. Gail Eckhardt
Publikováno v:
Clinical Cancer Research. 18:1051-1062
Purpose: Despite the availability of several active combination regimens for advanced colorectal cancer (CRC), the 5-year survival rate remains poor at less than 10%, supporting the development of novel therapeutic approaches. In this study, we focus
Autor:
Yu Sun, Nengtai Ouyang, Despina Komninou, Gerardo G. Mackenzie, Gang Xie, Basil Rigas, Kvetoslava Vrankova, Liqun Huang
Publikováno v:
Cancer Research. 71:7617-7627
Nonsteroidal anti-inflammatory drugs (NSAID) exhibit antineoplastic properties, but conventional NSAIDs do not fully meet safety and efficacy criteria for use as anticancer agents. In this study, we evaluated the chemotherapeutic efficacy of 5 novel
Autor:
Kiminobu Arima, Yoshiki Sugimura, Yoichi Iwamoto, Kenichiro Ishii, Hideki Kanda, Yasuhide Hori, Hideaki Kise, Norihito Soga, Kohei Nishikawa
Publikováno v:
Cancer Prevention Research. 4:87-96
In prostate cancer, tumor–stroma interactions play a critical role in the promotion of tumorigenesis, and thus the prevention of those interactions is a promising target to suppress tumor growth. Several studies demonstrated that alpha1-adrenocepto
Autor:
Bharat B. Aggarwal, Sanjit Dey, Sushovan Guha, Zhimin Tong, Parmeswaran Diagaradjane, Juri G. Gelovani, Vivek R. Yadav, Cemile Koca, Jayaraj Ravindran, Bokyung Sung, Sunil Krishnan, Ajaikumar B. Kunnumakkara, Amit Deorukhkar
Publikováno v:
Cancer Research. 70:8695-8705
Pancreatic cancers generally respond poorly to chemotherapy, prompting a need to identify agents that could sensitize tumors to treatment. In this study, we investigated the response of human pancreatic cells to γ-tocotrienol (γ-T3), a novel, unsat
Autor:
Cristina M. Karp, Eileen White, Kevin Bray, Robert S. DiPaola, Hsin-Yi Chen, Michael May, Shridar Ganesan, Vassiliki Karantza-Wadsworth
Publikováno v:
Molecular Cancer Research. 7:1487-1496
Apoptosis resistance is a hallmark of cancer linked to disease progression and treatment resistance, which has led to the development of anticancer therapeutics that restore apoptotic function. Antiapoptotic Bcl-2 is frequently overexpressed in refra