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Autor:
Sachin K. Khiste, Mohammad Burhan Uddin, Ronald A. Hill, Sami Nazzal, Zhijun Liu, Xin Gu, Salman B. Hosain, Kartik R. Roy, Yong-Yu Liu
Publikováno v:
Mol Cancer Ther
Ceramide (Cer) is an active cellular sphingolipid that can induce apoptosis or proliferation-arrest of cancer cells. Nanoparticle-based delivery offers an effective approach for overcoming bioavailability and biopharmaceutics issues attributable to t
Autor:
Yu Shyr, Li-Ching Huang, Charalambos C. Solomides, Yunguang Sun, Adam P. Dicker, Yong Antican Wang, Joshua D. Palmer, Bo Lu
Publikováno v:
Molecular Cancer Research. 15:896-904
Insulin-like growth factor binding protein 3 (IGFBP3) modulates cell growth through IGF-dependent and -independent mechanisms. Reports suggest that the serum levels of IGFBP3 are associated with various cancers and that IGFBP3 expression is significa
Autor:
John Karanicolas, Keerthana Gnanapradeepan, Jessica C. Leung, Maureen E. Murphy, Lei Ke, Tim Barnoud
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 29:PR08-PR08
The p53 tumor suppressor gene plays a central role in human cancer. In addition to mutation, there are genetic coding region variants of p53 that exist in different ethnic groups. In some cases, these variants have incomplete or impaired function and
Autor:
Danyi Wen, Yangfeng Ge, Ran Tao, Yifan Zhai, Miaoyi Wu, Yuanbao Li, Guangfeng Wang, Dajun Yang, Feifei Zhang, Jing Lv, Guoqin Zhai, Douglas D. Fang
Publikováno v:
Cancer Research. 80:6223-6223
Osimertinib (AZD9291) is the first-line treatment for EGFR-mutated NSCLC; however, the majority of patients inevitably develop resistance due to de novo genomic abnormalities, such as C797S mutation, EGFR exon 20 insertion, MET amplification and othe
Autor:
Pooja Mehta, Geeta Mehta, Manish S. Patankar, Susan M. Paskewitz, Mayur K. Kajla, Arvinder Kapur
Publikováno v:
Clinical Cancer Research. 25:NT-096
Ovarian cancer is the fifth most common cause of cancer-related deaths in women in the United States. Most women with ovarian cancer present with advanced disease. Even though initial response to surgery and chemotherapy is generally positive, many p
Autor:
Sam S. Yoon, Deirdre Jill Cohen, Benjamin Schmidt, Do Joong Park, Chang Hwan Yoon, Teresa S. Kim, Yelena Y. Janjigian, Hae-June Lee, Nicholas J. Thomas
Publikováno v:
Clinical Cancer Research. 20:3974-3988
Purpose: Gastric cancers may harbor a subset of cells with cancer stem cell (CSC) properties, including chemotherapy resistance, and CD44 is a gastric CSC marker. The Hedgehog (HH) pathway is a key developmental pathway that can be subverted by CSCs
Autor:
Sean A. Beausoleil, Michael Milhollen, Stephen J. Blakemore, Anthony Possemato, Claudia M. Espitia, Pete Smith, Michael P. Thomas, Allison Berger, Steffan T. Nawrocki, Kevin R. Kelly, Jennifer S. Carew
Publikováno v:
Clinical Cancer Research. 19:3577-3590
Purpose: Ovarian cancer has the highest mortality rate of all female reproductive malignancies. Drug resistance is a major cause of treatment failure and novel therapeutic strategies are urgently needed. MLN4924 is a NEDDylation inhibitor currently u
Autor:
Cristina M. Karp, Eileen White, Kevin Bray, Robert S. DiPaola, Hsin-Yi Chen, Michael May, Shridar Ganesan, Vassiliki Karantza-Wadsworth
Publikováno v:
Molecular Cancer Research. 7:1487-1496
Apoptosis resistance is a hallmark of cancer linked to disease progression and treatment resistance, which has led to the development of anticancer therapeutics that restore apoptotic function. Antiapoptotic Bcl-2 is frequently overexpressed in refra
Publikováno v:
Cancer Research. 67:4578-4585
Xeroderma pigmentosum group C (XPC) is an important DNA damage recognition protein that binds to damaged DNA at a very early stage during DNA repair. The XPC protein is also involved in DNA damage–induced cell cycle checkpoint regulation and apopto
Autor:
Hedi Haddada, Daniel Caput, Christian Davrinche, Jérôme Terrasson, Jacqueline Lulé, Sophie Allart, Hélène Martin
Publikováno v:
Cancer Research. 65:2787-2794
The discovery of p73, a p53-related protein with various isotypes resulting from different promoter usage or splicing events, provided new insights into regulation of neurogenesis and tumorigenesis. Among p73 isoforms described thus far, TA-truncated