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Autor:
Emily Kessler, Rodrigo Saad-Berreta, Hongwu Zheng, Vikram Deshpande, Krishna S. Tummala, Brandon Nicolay, William Shen, Ramzi Adil, Meng-Ju Wu, Juan Dubrot, Lipika Goyal, Vajira Weeresekara, Amaya Pankaj, Mathias Heikenwalder, Tong Wang, Mirian Fernandez-Vaquero, María García-Beccaria, Ting-Yu Wei, Kira E Olander, Sebastien Ronseaux, Vindhya Vijay, Qibiao Wu, Yuanli Zhen, Christine Hudson, Nabeel Bardeesy, Lei Shi, Rahul M. Kohli, Meiqi Luo, Yi Sun, Russell W. Jenkins, Robert T. Manguso, Cristina R. Ferrone, Joshua Merritt
Publikováno v:
Cancer Discovery. 12:812-835
Isocitrate dehydrogenase 1 mutations (mIDH1) are common in cholangiocarcinoma. (R)-2-hydroxyglutarate generated by the mIDH1 enzyme inhibits multiple α-ketoglutarate–dependent enzymes, altering epigenetics and metabolism. Here, by developing mIDH1
Autor:
Linlin Yang, Wenrui Duan, Duan-Liang Shyu, Changxian Shen, Amy Webb, Min Xu, Terence M. Williams
Publikováno v:
Mol Cancer Res
Lung squamous cell carcinoma (LUSC) accounts for one of three of non–small cell lung carcinoma (NSCLC) and 30% of LUSC patients present with locally advanced, unresectable/medically inoperable disease, who are commonly treated with definitive chemo
Autor:
J. Qiu, Umesh Bhanot, John T. Poirier, Yingqian Zhan, Elisa de Stanchina, Viola Allaj, Hirokazu Taniguchi, Fathema Uddin, Travis J. Hollmann, Jordana Ray-Kirton, Metamia Ciampricotti, Andrew Chow, Marina Asher, Richard Koche, Álvaro Quintanal-Villalonga, Jacklynn V. Egger, Yuan Hao, Joseph M. Chan, Shweta S Chavan, Charles M. Rudin, Michael H.A. Roehrl, Triparna Sen, Michael Offin, Irina Linkov, Nisargbhai S. Shah, P. Manoj
Publikováno v:
Cancer Res
Small cell lung cancer (SCLC) is an aggressive malignancy characterized by early metastasis and extreme lethality. The backbone of SCLC treatment over the past several decades has been platinum-based doublet chemotherapy, with the recent addition of
Autor:
Yinzhong Shang, Linlin Yan, Mingming Wu, Yong Zhu, Tao Zhu, Hui Yuan, Xiao Zhang, Zhengsheng Wu, Qianying Guo, Peter E. Lobie, Xin Ma
Publikováno v:
Cancer Research. 82:391-405
Estrogen receptor alpha (ERα) plays a vital role in the development of normal breast tissue and in breast cancer. By cross-analyzing The Cancer Genome Atlas (TCGA) database, ERα-regulated long noncoding RNA 1 (ERLC1) was identified as a long noncod
Autor:
Ryan C. Gimple, Guoxin Zhang, Linjie Zhao, Leo J.Y. Kim, Jia Z. Shen, Cheryl Kim, Briana C. Prager, Xujun Wang, Jean A. Bernatchez, Xiang-Dong Fu, Jeremy N. Rich, Kailin Yang, Jair L. Siqueira-Neto, Deobrat Dixit, Zhixin Qiu, Lukas Chavez, Zhe Zhu, Deguan Lv, Ye Zheng, Denise Hinz, Zhengyu Liang, Charles Spruck, Xiuxing Wang, Chunyu Jin, Qiyuan Yang, Qiulian Wu, Lihua Min, Katherine A. Jones, Zhen Dong, Shruti Bhargava
Publikováno v:
Cancer Discov
Glioblastoma (GBM) is the most lethal primary brain cancer characterized by therapeutic resistance, which is promoted by GBM stem cells (GSC). Here, we interrogated gene expression and whole-genome CRISPR/Cas9 screening in a large panel of patient-de
Autor:
Becky K. C. Chan, Stephanie Ma, Hoi Yee Chu, Koon Ho Wong, Cindy S.W. Tong, Gigi C. G. Choi, Maggie S. H. Cheung, Tin Lok Wong, Yuanhua Huang, Feng Xu, John H. C. Fong, Alan S.L. Wong, Lakhansing Pardeshi, Man Tong, Kylie Hin-Man Mak
Publikováno v:
Cancer Research. 81:6219-6232
Systematic testing of existing drugs and their combinations is an attractive strategy to exploit approved drugs for repurposing and identifying the best actionable treatment options. To expedite the search among many possible drug combinations, we de
Autor:
Arnab Ray Chaudhuri, Jos Jonkers, Sjoerd Klarenbeek, Eline van der Burg, Bing Xia, Kerstin Hahn, Nicole S. Verkaik, Jeroen Essers, Haico van Attikum, Magdalena B. Rother, Colin Pritchard, Peter Bouwman, Hanneke van der Gulden, Chirantani Mukherjee, Emilia M. Pulver, Ivo J. Huijbers, Anne Paulien Drenth, Stefan J. Roobol, Roebi de Bruijn, Marieke van de Ven, Renske de Korte-Grimmerink, Maria Valeria Lattanzio, Gerarda van de Kamp, Dik C. van Gent
Publikováno v:
Cancer Research, 81(24), 6171-6182. American Association for Cancer Research Inc.
Cancer Research, 81(24), 6171-6182. AMER ASSOC CANCER RESEARCH
Cancer Research, 81(24), 6171-6182. AMER ASSOC CANCER RESEARCH
The BRCA1 tumor suppressor gene encodes a multidomain protein for which several functions have been described. These include a key role in homologous recombination repair (HRR) of DNA double-strand breaks, which is shared with two other high-risk her
Autor:
Jawairia Atif, Kimberly C. Wiegand, T. Michael Underhill, Jacqueline C.Y. Lai, Pauline Johnson, Spencer A. Freeman, Michael R. Gold, Kelly M. McNagny, Marie-Renée Blanchet, Arif A. Arif, Calvin D. Roskelley, Pamela Dean, Yu-Hsuan Huang
Publikováno v:
Molecular Cancer Research. 19:2096-2109
A rate-limiting step for circulating tumor cells to colonize distant organ sites is their ability to locate a microenvironmental niche that supports their survival and growth. This can be achieved by features intrinsic to the tumor cells and/or by th
Publikováno v:
Molecular Cancer Therapeutics. 20:2519-2526
Immune-related pneumonitis is an important toxicity associated with checkpoint inhibitor therapy with anti–PD-1 or anti–PD-L1 antibodies, often necessitating discontinuation of treatment. Development of methods to mitigate checkpoint inhibitor–
Transglutaminase 2 Maintains Hepatocyte Growth Factor Signaling to Enhance the Cancer Cell Phenotype
Autor:
Warren Naselsky, Wen Xu, Xi Chen, Suruchi Shrestha, Gautam Adhikary, Jeffrey W. Keillor, Richard L. Eckert
Publikováno v:
Mol Cancer Res
Transglutaminase 2 (TG2) is a key epidermal squamous cell carcinoma cancer cell survival protein. However, how TG2 maintains the aggressive cancer phenotype is not well understood. The present studies show that TG2, which is highly expressed in epide