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Publikováno v:
Molecular Cancer Research. 16:1309-1318
Phenobarbital, a nongenotoxic hepatocarcinogen, induces hepatic proliferation and promotes development of hepatocellular carcinoma (HCC) in rodents. Nuclear receptor constitutive active/androstane receptor (NR1I3/CAR) regulates the induction and prom
Autor:
Tatsushi Yokogawa, Seiji Miyahara, Eiji Matsushima, Yayoi Takao, Takeshi Wakasa, Junko Taguchi, Kenichi Matsuo, Keisuke Yamamura, Khoon Tee Chong, Hitoshi Miyakoshi, Wakako Yano, Masayoshi Fukuoka, Kunihiro Yoshisue, Akio Fujioka
Publikováno v:
Molecular Cancer Therapeutics. 17:1683-1693
5-Fluorouracil (5-FU) is an antimetabolite and exerts antitumor activity via intracellularly and physiologically complicated metabolic pathways. In this study, we designed a novel small molecule inhibitor, TAS-114, which targets the intercellular met
Autor:
Samuel D. Rabkin, Slawomir Antoszczyk, Robert L. Martuza, Cole Peters, Hiroaki Wakimoto, Dipongkor Saha
Publikováno v:
Clinical Cancer Research. 24:3409-3422
Purpose: Glioblastoma (GBM), a fatal brain cancer, contains a subpopulation of GBM stem-like cells (GSCs) that contribute to resistance to current therapy. Angiogenesis also plays a key role in GBM progression. Therefore, we developed a strategy to t
Autor:
Mark X. Sliwkowski, Jun Guo, Lisa Crocker, Jennifer A. Lacap, Gail Lewis Phillips, Ben-Quan Shen, Daniela Bumbaca Yadav, Guangmin Li
Publikováno v:
Molecular Cancer Therapeutics. 17:1441-1453
The receptor tyrosine kinase HER2 is overexpressed in approximately 20% of breast cancer, and its amplification is associated with reduced survival. Trastuzumab emtansine (Kadcyla, T-DM1), an antibody–drug conjugate that is comprised of trastuzumab
Autor:
Siwen Kang, Jianying Zhang, Elshafa H. Ahmed, Michael A. Caligiuri, Erin N. Glankler, Don M. Benson, Youssef Youssef, Emma R. Barrett, Wing Keung Chan, Jianhua Yu, Luxi Chen, Aman Prasad, Alex M. Carter
Publikováno v:
Cancer Immunology Research. 6:776-787
Multiple myeloma (MM) is an incurable hematologic malignancy of plasma cells, with an estimated 30,000 new cases diagnosed each year in the United States, signifying the need for new therapeutic approaches. We hypothesized that targeting MM using a b
Autor:
Isaac K. Nardi, Dan J. Raz, Lu Yang, Jinhui Wang, Jami Wang, Rajendra P. Pangeni, Xinwei Yun, Melissa Bonner, Ming Gao, Keqiang Zhang, Jun Wu
Publikováno v:
Molecular Cancer Research. 16:1161-1171
Loss of monoubiquitination of histone H2B (H2Bub1) was found to be associated with poor-differentiation and enhanced malignancy of lung adenocarcinoma. This study investigated the association and impact of the ubiquitin-specific peptidase 22 (USP22),
Antibody-Dependent Cellular Phagocytosis by Macrophages is a Novel Mechanism of Action of Elotuzumab
Autor:
Irene M. Ghobrial, Natalie Bezman, Michele Moschetta, Antonio Sacco, Aldo M. Roccaro, Yu-Tzu Tai, Daisy Huynh, Siobhan Glavey, Yuji Mishima, Alexandre Detappe, Jamil Azzi, Jennifer L. Guerriero, Ahmed T. Kurdi, Amy Jhatakia, Chia Jen Liu, Michael Robbins, Salomon Manier
Publikováno v:
Molecular Cancer Therapeutics. 17:1454-1463
Elotuzumab, a recently approved antibody for the treatment of multiple myeloma, has been shown to stimulate Fcγ receptor (FcγR)-mediated antibody-dependent cellular cytotoxicity by natural killer (NK) cells toward myeloma cells. The modulatory effe
Autor:
Kuang-Hsiang Chuang, Guiyang Jiang, Taichi Mizushima, Mototsugu Oya, Hiroki Ide, Hiroshi Miyamoto, Satoshi Inoue
Publikováno v:
Molecular Cancer Therapeutics. 17:1566-1574
Although radiotherapy often with chemotherapy has been shown to offer a survival benefit comparable with that of radical cystectomy in select patients with bladder cancer, the development of radiosensitization strategies may significantly enhance its
Autor:
Troy Bloom, Gege Tan, Alexey Lugovskoy, Emily Pace, Victoria Rimkunas, Charlene Minx, Lin Nie, Jason Baum, Sergio Iadevaia, Robert M. Straubinger, J. Marc Pipas, Daryl C. Drummond, Michael D. Curley, Sharlene Adams, Ulrik B. Nielsen, Akos Czibere, Adam Camblin, Birgit Schoeberl, Vasileios Askoxylakis, Chrystal U. Louis
Publikováno v:
Clinical Cancer Research. 24:2873-2885
Purpose: Insulin-like growth factor receptor 1 (IGF-1R) is critically involved in pancreatic cancer pathophysiology, promoting cancer cell survival and therapeutic resistance. Assessment of IGF-1R inhibitors in combination with standard-of-care chemo
Autor:
Debabrata Mukhopadhyay, Shamit K. Dutta, Xun Gong, Enfeng Wang, Freddy T. Nguyen, Santanu Bhattacharya, Joseph R. Caplette, Manki Son, Michael S. Strano
Publikováno v:
PMC
Pancreatic ductal adenocarcinoma (PDAC) is a highly desmoplastic cancer with limited treatment options. There is an urgent need for tools that monitor therapeutic responses in real time. Drugs such as gemcitabine and irinotecan elicit their therapeut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::915b86183639ca42a1287f0c4461afa0
https://hdl.handle.net/1721.1/125234
https://hdl.handle.net/1721.1/125234