Zobrazeno 61 - 70
of 1 183
pro vyhledávání: ''
Publikováno v:
Cancer Research. 80:3945-3958
Malignant glioma constitutes one of the fatal primary brain tumors in adults. Such poor prognosis calls for a better understanding of cancer-related signaling pathways of this disease. Here we elucidate a MYC-miRNA-MXI1 feedback loop that regulates p
Autor:
Amanda Scherer, Emily A. Laverty, David G. Kirsch, Victoria R. Stephens, William C. Eward, Ashutosh Chilkoti, Eric M. Mastria, Gavin R. McGivney, Warren Floyd, Soumen Saha, Kathleen A. Ashcraft, Parisa Yousefpour, Rebecca D. Dodd, Wade R. Gutierrez, Wesley Huang, Yan Ma, Mark Chen, Diana M. Cardona, Vickie Knepper-Adrian
Publikováno v:
Clin Cancer Res
Purpose: Nanoparticle-encapsulated drug formulations can improve responses to conventional chemotherapy by increasing drug retention within the tumor and by promoting a more effective antitumor immune response than free drug. New drug delivery modali
Autor:
Alessandro Cavaliere, Michaela Deiana, Camilla Zecchetto, Davide Melisi, Raffaela Santoro, Sara Lonardi, Geny Piro, Domenico Mangiameli, Vita Fedele, Diana Bazan, Francesca Simionato, Valeria Merz, Maria Teresa Valenti, Fabio Sabbadini
Publikováno v:
Clinical Cancer Research. 26:4661-4669
Purpose: Pancreatic cancer is one of the most lethal solid tumors, mainly because of its intrinsic chemoresistance. We identified TAK1 as a central hub sustaining this resistance. Nanoliposomal irinotecan (nal-IRI) is a novel treatment for metastatic
Autor:
Lindsay S. Moore, Hailey A. Houson, Jason M. Warram, Neha Udayakumar, Hope M. Amm, Tiara Napier, Anna G. Sorace, Yolanda E. Hartman, Aditi Jani, Nynke S. van den Berg
Publikováno v:
Mol Cancer Ther
Maximal safe resection of malignant tissue is associated with improved progression-free survival and better response to radiation and chemotherapy for patients with glioblastoma (GBM). 5-Aminolevulinic acid (5-ALA) is the current FDA-approved standar
Autor:
Yijie Wang, Jennifer M. Curry, Ronald Glaser, Laura A. Sumner, A. Courtney DeVries, Amy C. Gross, Nisha Crouser, Jeffrey L. Voorhees, Timothy D. Eubank, Michael T. Bailey, Eric V. Yang, Kayla J. Steinberger, Clay B. Marsh
Publikováno v:
Cancer Prev Res (Phila)
Psychological stressors have been implicated in the progression of various tumor types. We investigated a role for stress in tumor immune cell chemotaxis in the B16F10 mouse model of malignant melanoma. We exposed female mice to 6-hour periods of res
Autor:
Xiaorong Dong, Gang Wu, Yuying Liu, Jingwei Ma, Huafeng Zhang, Haiqing Fang, Li Liu, Bo Huang, Liang Tang, Rui Meng, Jincheng Liu, Fei Ma, Jie Chen, Liyan Zhu, Dianheng Wang, Pingwei Xu, Keke Wei, Ke Tang, Jing Xie, Yi Zhang, Kunyu Yang
Publikováno v:
Cancer Immunology Research. 8:1193-1205
Malignant pleural effusion (MPE) is a frequent complication of various cancers and often leads to a poor quality of life, prognosis, and life expectancy, and its management remains palliative. New approaches that can effectively treat MPE are highly
Autor:
Chi Luo, Elizabeth A. Perry, Kfir Sharabi, Pere Puigserver, Lipika Goyal, Andrew X. Zhu, Maximilian Hatting, Jiaxin Liang, Clint D.J. Tavares, Piotr Sicinski, Amitabh Srivastava, Marc Bilodeau
Publikováno v:
Cancer Res
Type 2 diabetes, which is mainly linked to obesity, is associated with increased incidence of liver cancer. We have previously found that in various models of obesity/diabetes, hyperinsulinemia maintains heightened hepatic expression of cyclin D1, su
Autor:
Simon Bayle, Victor Quereda, Andrii Monastyrskyi, Derek R. Duckett, Massimilliano Aceti, Sylvia M Frydman, Ainhoa Nieto, Wayne Grant, Samer S. Sansil, Patricia McDonald, Mingxiang Teng, Francesca Vena, William R. Roush
Publikováno v:
Mol Cancer Ther
Although gemcitabine is the cornerstone of care for pancreatic ductal adenocarcinoma (PDA), patients lack durable responses and relapse is inevitable. While the underlying mechanisms leading to gemcitabine resistance are likely to be multifactorial,
Autor:
David L. Kerr, Jason A. Somarelli, William C. Eward, Gireesh B. Reddy, David S. Hsu, David Needham, Brian E. Brigman, Artak Tovmasyan, Ivan Spasojevic
Publikováno v:
Molecular Cancer Therapeutics. 19:1448-1461
Therapeutic advances for osteosarcoma have stagnated over the past several decades, leading to an unmet clinical need for patients. The purpose of this study was to develop a novel therapy for osteosarcoma by reformulating and validating niclosamide,
Autor:
Maria G. Castro, Wang Jia, Gary Kohanbash, Victoria M. Fiesler, Gulnaz Begum, Dandan Sun, Nduka Amankulor, Jacob Dodelson, Jenesis D. Gayden, Baoshan Sun, Lanxin Luo, Xiudong Guan, Baoli Hu, Dawei Ding, Nabiul Hasan
Publikováno v:
Molecular Cancer Therapeutics. 19:1550-1561
Glioma is one of the most common primary malignant tumors of the central nervous system accounting for approximately 40% of all intracranial tumors. Temozolomide is a conventional chemotherapy drug for adjuvant treatment of patients with high-risk gl