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of 471
pro vyhledávání: ''
Autor:
Dan R. Robinson, Viktoriya Korchina, Xuxu Gou, Nicholas Mitsiades, Shunqiang Li, Jianhong Hu, Harshavardhan Doddapaneni, Matthew J. Ellis, Purba Singh, Beom-Jun Kim, Alana L. Welm, Michael T. Lewis, Diana Fandino, Lacey E. Dobrolecki, Meenakshi Anurag, Sinem Seker, Jonathan T. Lei, Airi Han, Saif Rehman, Adrian V. Lee, Charles E. Foulds
Publikováno v:
Cancer Res
Genomic analysis has recently identified multiple ESR1 gene translocations in estrogen receptor alpha–positive (ERα+) metastatic breast cancer (MBC) that encode chimeric proteins whereby the ESR1 ligand binding domain (LBD) is replaced by C-termin
Autor:
Todd P. Knutson, Yingzheng Xu, Kathryn L. Schwertfeger, Jesse W. Williams, Ying Wang, Danielle N. Huggins, Rebecca S. LaRue
Publikováno v:
Cancer Res
While macrophages are among the most abundant immune cell type found within primary and metastatic mammary tumors, how their complexity and heterogeneity change with metastatic progression remains unknown. Here, macrophages were isolated from the lun
Autor:
Sung Chul Lim, Youngnam Cho, Y. J. Kim, Seungmin Kang, Kyu Min Kim, Moon-Chang Baek, Keon Wook Kang, Miso Park, Ju Hyun Bae, Sung Baek Jeong, Jin Ki Kim, Dae Won Jun, Yong June Choi, Seung-Hyun Lee, Jiwon Kim, Wankyu Kim, HyungJae Lee, Sung Yun Cho
Publikováno v:
Cancer Research. 81:3539-3553
Extracellular vesicles (EV) in the tumor microenvironment have emerged as crucial mediators that promote proliferation, metastasis, and chemoresistance. However, the role of circulating small EVs (csEV) in cancer progression remains poorly understood
Autor:
Krishanthan Vigneswaran, Shoeb Lallani, Renee Read, Nathaniel H. Boyd, Andrew B. Boucher, Se-Yeong Oh, Stewart G. Neill, Jeffrey J. Olson
Publikováno v:
Clin Cancer Res
Purpose: Glioblastomas (GBMs), neoplasms derived from glia and neuroglial progenitor cells, are the most common and lethal malignant primary brain tumors diagnosed in adults, with a median survival of 14 months. GBM tumorigenicity is often driven by
Autor:
Zahid H. Siddik, Bangxing Hong, Uksha Saini, David E. Cohn, Anil K. Sood, Guangsheng Pei, Guangan He, Zhongming Zhao, Yuanqing Yan, Karuppaiyah Selvendiran, Valerie Chapa, Balveen Kaur, Ji Young Yoo, Puneet Modgil
Publikováno v:
Clin Cancer Res
Purpose:Here we investigated the impact of oncolytic herpes simplex virus (HSV) treatment on cisplatin sensitivity of platinum-resistant ovarian cancer, and the impact of the combination on immunotherapy.Experimental Design:Therapeutic efficacy of th
Autor:
Britta M. Jacobsen, Jessica Finlay-Schultz, Reema Wahdan-Alaswad, Susan M. Edgerton, Bryan R. Haugen, Hyunmin Kim, Carol A. Sartorius, Elizabeth A. Wellberg, Ann D. Thor, Bolin Liu, Aik Choon Tan, Hiba Salem
Publikováno v:
Clinical Cancer Research. 27:585-597
Purpose: Thyroid disease is a frequent comorbidity in women with breast cancer, and many require thyroid hormone replacement therapy (THRT). We postulated that THRT has a deleterious clinical effect mechanistically through hormonal interactions, nucl
Autor:
Steven A. Johnsen, Feda H. Hamdan, Elisabeth Hessmann, Christine S Gibhardt, Zeynab Najafova, Jochen Gaedcke, Philipp Ströbel, Ivan Bogeski, Volker Ellenrieder, Waltraut Kopp, Xin Wang, Ana P. Kutschat, Alexander Q. Wixom
Publikováno v:
Cancer Res
Pancreatic ductal adenocarcinoma (PDAC) displays a dismal prognosis due to late diagnosis and high chemoresistance incidence. For advanced disease stages or patients with comorbidities, treatment options are limited to gemcitabine alone or in combina
Publikováno v:
Clin Cancer Res
Purpose: Statins are cholesterol-depleting drugs used to treat patients with hypercholesterolemia. Preclinically, statins disrupt trafficking of receptors present at the cell membrane. Membrane receptors, defined as tumor biomarkers and therapeutic t
Autor:
Brian C. Franczak, Mary M. Hitt, Rees G. Kelly, Megan A. Desaulniers, Nicole Favis, Ryan S. Noyce, David H. Evans, Mira M. Shenouda, Brittany A Umer, Troy A. Baldwin
Publikováno v:
Cancer Immunology Research. 8:618-631
Vaccinia virus (VACV) is a double-stranded DNA virus that devotes a large portion of its 200 kbp genome to suppressing and manipulating the immune response of its host. Here, we investigated how targeted removal of immunomodulatory genes from the VAC
Autor:
Deukwoo Kwon, Nipun B. Merchant, Michelle L. Reyzer, Xizi Dai, Brent A. Willobee, Supriya Srinivasan, Siddharth Mehra, Nagaraj S. Nagathihalli, Nilesh Kashikar, Austin R. Dosch, Richard M. Caprioli
Publikováno v:
Mol Cancer Res
Lack of durable response to cytotoxic chemotherapy is a major contributor to the dismal outcomes seen in pancreatic ductal adenocarcinoma (PDAC). Extensive tumor desmoplasia and poor vascular supply are two predominant characteristics which hinder th