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pro vyhledávání: ''
Autor:
Arnab Ray Chaudhuri, Jos Jonkers, Sjoerd Klarenbeek, Eline van der Burg, Bing Xia, Kerstin Hahn, Nicole S. Verkaik, Jeroen Essers, Haico van Attikum, Magdalena B. Rother, Colin Pritchard, Peter Bouwman, Hanneke van der Gulden, Chirantani Mukherjee, Emilia M. Pulver, Ivo J. Huijbers, Anne Paulien Drenth, Stefan J. Roobol, Roebi de Bruijn, Marieke van de Ven, Renske de Korte-Grimmerink, Maria Valeria Lattanzio, Gerarda van de Kamp, Dik C. van Gent
Publikováno v:
Cancer Research, 81(24), 6171-6182. American Association for Cancer Research Inc.
Cancer Research, 81(24), 6171-6182. AMER ASSOC CANCER RESEARCH
Cancer Research, 81(24), 6171-6182. AMER ASSOC CANCER RESEARCH
The BRCA1 tumor suppressor gene encodes a multidomain protein for which several functions have been described. These include a key role in homologous recombination repair (HRR) of DNA double-strand breaks, which is shared with two other high-risk her
Autor:
Dan R. Robinson, Viktoriya Korchina, Xuxu Gou, Nicholas Mitsiades, Shunqiang Li, Jianhong Hu, Harshavardhan Doddapaneni, Matthew J. Ellis, Purba Singh, Beom-Jun Kim, Alana L. Welm, Michael T. Lewis, Diana Fandino, Lacey E. Dobrolecki, Meenakshi Anurag, Sinem Seker, Jonathan T. Lei, Airi Han, Saif Rehman, Adrian V. Lee, Charles E. Foulds
Publikováno v:
Cancer Res
Genomic analysis has recently identified multiple ESR1 gene translocations in estrogen receptor alpha–positive (ERα+) metastatic breast cancer (MBC) that encode chimeric proteins whereby the ESR1 ligand binding domain (LBD) is replaced by C-termin
Autor:
Todd P. Knutson, Yingzheng Xu, Kathryn L. Schwertfeger, Jesse W. Williams, Ying Wang, Danielle N. Huggins, Rebecca S. LaRue
Publikováno v:
Cancer Res
While macrophages are among the most abundant immune cell type found within primary and metastatic mammary tumors, how their complexity and heterogeneity change with metastatic progression remains unknown. Here, macrophages were isolated from the lun
Autor:
Shizhen Zhu, Ting Tao, Itzhak Nissim, Hui Feng, Xiaodan Qin, A. Thomas Look, Jennifer M. Finan, Rindert Missiaen, Guoliang Qing, Jacob Athoe, Amandeep S. Saini, Nicolas Skuli, M. Celeste Simon, Andrew Lam, Annie Kennedy, Nicole M. Anderson
Publikováno v:
Cancer Res
High-risk neuroblastoma remains therapeutically challenging to treat, and the mechanisms promoting disease aggression are poorly understood. Here, we show that elevated expression of dihydrolipoamide S-succinyltransferase (DLST) predicts poor treatme
Autor:
Sung Chul Lim, Youngnam Cho, Y. J. Kim, Seungmin Kang, Kyu Min Kim, Moon-Chang Baek, Keon Wook Kang, Miso Park, Ju Hyun Bae, Sung Baek Jeong, Jin Ki Kim, Dae Won Jun, Yong June Choi, Seung-Hyun Lee, Jiwon Kim, Wankyu Kim, HyungJae Lee, Sung Yun Cho
Publikováno v:
Cancer Research. 81:3539-3553
Extracellular vesicles (EV) in the tumor microenvironment have emerged as crucial mediators that promote proliferation, metastasis, and chemoresistance. However, the role of circulating small EVs (csEV) in cancer progression remains poorly understood
Autor:
Krishanthan Vigneswaran, Shoeb Lallani, Renee Read, Nathaniel H. Boyd, Andrew B. Boucher, Se-Yeong Oh, Stewart G. Neill, Jeffrey J. Olson
Publikováno v:
Clin Cancer Res
Purpose: Glioblastomas (GBMs), neoplasms derived from glia and neuroglial progenitor cells, are the most common and lethal malignant primary brain tumors diagnosed in adults, with a median survival of 14 months. GBM tumorigenicity is often driven by
Autor:
Steven A. Johnsen, Feda H. Hamdan, Elisabeth Hessmann, Christine S Gibhardt, Zeynab Najafova, Jochen Gaedcke, Philipp Ströbel, Ivan Bogeski, Volker Ellenrieder, Waltraut Kopp, Xin Wang, Ana P. Kutschat, Alexander Q. Wixom
Publikováno v:
Cancer Res
Pancreatic ductal adenocarcinoma (PDAC) displays a dismal prognosis due to late diagnosis and high chemoresistance incidence. For advanced disease stages or patients with comorbidities, treatment options are limited to gemcitabine alone or in combina
Publikováno v:
Clin Cancer Res
Purpose: Statins are cholesterol-depleting drugs used to treat patients with hypercholesterolemia. Preclinically, statins disrupt trafficking of receptors present at the cell membrane. Membrane receptors, defined as tumor biomarkers and therapeutic t
Autor:
Sha Jin, Julie J Purkal, Yu Xiao, Larry R. Solomon, Dan Cojocari, Relja Popovic, Nari Talaty, Erwin R. Boghaert, Darren C. Phillips, Joel D. Leverson
Publikováno v:
Clinical Cancer Research. 26:3371-3383
Purpose: Patients with acute myeloid leukemia (AML) frequently do not respond to conventional therapies. Leukemic cell survival and treatment resistance have been attributed to the overexpression of B-cell lymphoma 2 (BCL-2) and aberrant DNA hypermet
Autor:
Ruihua Bai, Tianshun Zhang, Yongping Song, Qingxin Xia, Kangdong Liu, Zigang Dong, Qiushi Wang, Xiang Li, Keke Wang, Xiaoyu Chang, Ting Wang, Ann M. Bode, Joohyun Ryu, Wei-Ya Ma
Publikováno v:
Cancer Prevention Research. 12:837-848
Lung cancer is the leading cause of cancer-related death worldwide. However, promising agents for lung cancer prevention are still very limited. Identification of preventive targets and novel effective preventive agents is urgently needed for clinica