Zobrazeno 21 - 30
of 2 141
pro vyhledávání: ''
Autor:
Cristiana Sessa, Monia Guidi, Laura Moser, Eleftherios P. Samartzis, Mariarosa Pascale, Ilaria Colombo, Tatiana Terrot, Milo Frattini, Simone Brandt, Anastasios Stathis, Sheila Gaggetta, Sofia Genta, Federica Martorana
Publikováno v:
Clinical Cancer Research. 27:5012-5019
Purpose: This phase I study evaluated safety, tolerability, pharmacokinetics, and preliminary activity of the PI3K/mTORC1/2 dual inhibitor gedatolisib combined with carboplatin and paclitaxel. Patients and Methods: Patients with advanced solid tumors
Autor:
Amy E. DeZern, Alan F. List, Jeffrey E. Lancet, Hannah Newman, Eric Padron, Maria E. Balasis, Mikkael A. Sekeres, Rami S. Komrokji, Anthony M. Hunter, Qianxing Mo, Traci Kruer, Sandrine Niyongere, Markus Ball, Christopher Letson, Aaron T. Gerds, Gail J. Roboz, David A. Sallman, Hailing Zhang, Onyee Chan, David P. Steensma, William Dominguez-Viqueira
Publikováno v:
Clinical Cancer Research. 27:6095-6105
Purpose: Chronic myelomonocytic leukemia (CMML) is a rare leukemia characterized by peripheral monocytosis with no disease-modifying therapies. CMML cells are uniquely hypersensitive to granulocyte-macrophage colony-stimulating factor (GM-CSF) and ro
Autor:
Gang An, Chenmu Du, Shu Cheng, Jianfeng Zhou, Binghao Wu, Haiyi Guo, Lingzhi Yan, Liye Zhong, Yiling Yu, Jie Jin, Liping Xie, Jinhua Zhong, Daobin Zhou, Jianyong Li, Keshu Zhou, Lugui Qiu
Publikováno v:
Clinical Cancer Research. 27:5492-5501
Purpose: Although Bruton tyrosine kinase (BTK) inhibitors have demonstrated promising efficacy in patients with Waldenström macroglobulinemia (WM), data in Asian populations are scarce. This trial is the first to investigate the effect of a BTK inhi
Autor:
Mobolaji Odewole, Peng Wei, Amit G. Singal, Jessica I. Sanchez, Nicole E. Rich, Suet Ying Kwan, Lin Tan, Lucas Veillon, Philip L. Lorenzi, Laura Beretta, Jingjing Jiao, Marc O. Warmoes
Publikováno v:
Cancer Prev Res (Phila)
Novel biomarkers for HCC surveillance in cirrhotic patients are urgently needed. Exosomes and their lipid content in particular represent potentially valuable noninvasive diagnostic biomarkers. We isolated exosomes from plasma of 72 cirrhotic patient
Autor:
Yoshiki Miyachi, Seiichiro Yamamoto, Hideaki Kaneda, Eiji Nakatani, Kohei Saito, Hiroshi Itoh, Yoko Sato
Publikováno v:
Cancer Prevention Research. 14:863-872
Preclinical studies suggest that statins contribute to the prevention of pancreatic cancer; however, the results of epidemiologic studies are inconsistent. Furthermore, sufficient data are unavailable for the general population of Asia. Here, we cond
Autor:
Michael Fulkerson, Jeffrey A. Cadeddu, Sydney Haldeman, Roy Elias, Qurratulain Yousuf, Qing Yuan, Vitaly Margulis, Alana Christie, Ananth J. Madhuranthakam, Robert C. Sibley, DK Dwivedi, James Brugarolas, Payal Kapur, Asghar Hajibeigi, Ze Zhang, Junyu Guo, Aditya Bagrodia, Matthew A. Lewis, Yin Xi, Tiffani McKenzie, Allison Joyce, Hollis Notgrass, Ivan Pedrosa, Tao Wang, Durga Udayakumar, Alberto Diaz de Leon, Renée M. McKay
Publikováno v:
Clin Cancer Res
Purpose: Intratumoral heterogeneity (ITH) challenges the molecular characterization of clear cell renal cell carcinoma (ccRCC) and is a confounding factor for therapy selection. Most approaches to evaluate ITH are limited by two-dimensional ex vivo t
Publikováno v:
Cancer Prevention Research. 14:873-884
Oral squamous cell carcinoma (OSCC) may be associated with precursor lesions known as oral potentially malignant disorders (OPMD). Few studies have reported on how OPMD diagnosis affects early detection and outcome of OSCC. We reviewed a large series
Autor:
Jeffrey A. Meyerhardt, Edward Giovannucci, Koichiro Haruki, Mingyang Song, Eliezer M. Van Allen, Kana Wu, Marios Giannakis, Shuji Ogino, Andrew D. Cherniack, Jonathan A. Nowak, Brendan Reardon, Rong Zhong, Charles S. Fuchs, Henry Lee-Six, Carino Gurjao, Liam F. Spurr, Xuehong Zhang, Yvonne Y. Li, Tomotaka Ugai
Publikováno v:
Cancer Discov
Several risk factors have been established for colorectal cancer, yet their direct mutagenic effects in patients' tumors remain to be elucidated. Here, we leveraged whole-exome sequencing data from 900 colorectal cancer cases that had occurred in thr
Autor:
Bose Kochupurakkal, Courtney Gannon, Adrienne de Jonge, Jean-Bernard Lazaro, Sarah Kelland, Khanh T. Do, Jennifer Hedglin, Alan D. D'Andrea, Allison Powers, Kalindi Parmar, Loan Vuong, Nicholas Quinn, Geoffrey I. Shapiro
Publikováno v:
Clinical Cancer Research. 27:4710-4716
Purpose:Checkpoint kinase 1 (CHK1) plays a central role in the response to replication stress through modulation of cell-cycle checkpoints and homologous recombination (HR) repair. In BRCA-deficient cancers with de novo or acquired PARP inhibitor res
Autor:
G. Iyer, Hikmat Al-Ahmadie, Erin L. Kirk, David B. Solit, Eugene J. Pietzak, William Y. Kim, Sara E. Wobker, Markia A. Smith, Kyle Roell, Matthew E. Nielsen, Bernard H. Bochner, Melissa A. Troester, Helena Furberg, Guido Dalbagni, Jeffrey S. Damrauer, Andrew F. Olshan, Katherine A. Hoadley, Halei C. Benefield, Matthew I. Milowsky, Xuezheng Sun
Publikováno v:
Clin Cancer Res
Purpose: Improved risk stratification and predictive biomarkers of treatment response are needed for non–muscle-invasive bladder cancer (NMIBC). Here we assessed the clinical utility of targeted RNA and DNA molecular profiling in NMIBC. Experimenta