Zobrazeno 1 - 10
of 287
pro vyhledávání: ''
Autor:
Vinod P. Balachandran, James J. Harding, Andrea Cercek, Michael I. D’Angelica, William R. Jarnagin, Louise Catherine Connell, Joshua S. Jolissaint, T. Peter Kingham, Kevin C. Soares, Kenneth Seier, Mithat Gonen, Nancy E. Kemeny, Ramyasree Madupuri, Ritika Kundra, Alice C. Wei, Thomas Boerner, Jeffrey A. Drebin, Carlie S. Sigel, Paul Shin, Efsevia Vakiani
Publikováno v:
Clin Cancer Res
Purpose: Lymph node metastasis (LNM) drastically reduces survival after resection of intrahepatic cholangiocarcinoma (IHC). Optimal treatment is ill defined, and it is unclear whether tumor mutational profiling can support treatment decisions. Experi
Autor:
Soo-Ryum Yang, Achim A. Jungbluth, Ezra Y. Rosen, Douglas A. Mata, Kerry Mullaney, Umut Aypar, Denise Frosina, Alexander Drilon, Marc Ladanyi, Jaclyn F. Hechtman, Yanming Zhang, Gowtham Jayakumaran, Natasha Rekhtman, Ryma Benayed
Publikováno v:
Clin Cancer Res
Purpose: Selpercatinib and pralsetinib induce deep and durable responses in patients with advanced RET fusion–positive lung and thyroid cancer. RET fusion testing strategies with rapid and reliable results are critical given recent FDA approval. He
Autor:
Rajiv M. Patel, Jae Eun Choi, Douglas R. Fullen, Nallasivam Palanisamy, Tasha M. Hughes, Bryan Johnson, Xiaoming Wang, Christopher K. Bichakjian, May P. Chan, Javed Siddiqui, Lili Zhao, Shannon Carskadon, Josh N. Vo, Steven M. Hrycaj, Kelly L. Harms, Scott A. Tomlins, Rahul Mannan, Scott A. McLean, Vincent T. Ma, Daniel R. Rhodes, Paul W. Harms
Publikováno v:
Clin Cancer Res
Purpose: Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma that can be divided into two classes: virus-positive (VP) MCC, associated with oncogenic Merkel cell polyomavirus (MCPyV); and virus-negative (VN) MCC, associate
Autor:
Nina L. Jebsen, Brynjar Mauseth, Ketil André Camilio, Ahmad Awada, George Lazaridis, Christiane Jungels, Hamina Patel, Aurélien Marabelle, Vibeke Sundvold, Fabienne Hermitte, Delphine Loirat, James Spicer, Øystein Rekdal, Berit Nicolaisen, R Kristeleit, Paal Brunsvig, Andrew Saunders, Dag Erik Jøssang, Jérôme Galon, Baldur Sveinbjørnsson, Jean Francois Baurain
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. xx, no.xx, p. xx (2021)
Purpose: LTX-315 is a first-in-class, 9-mer membranolytic peptide that has shown potent immunomodulatory properties in preclinical models. We conducted a phase I dose-escalating study of intratumoral LTX-315 administration in patients with advanced s
Autor:
Veronika Fedirko, March E. Seabrook, John A. Baron, Robin E. Rutherford, Marjorie L. McCullough, Rami Yacoub, W. Dana Flanders, David C. Gibbs, Tapasya Raavi, Roberd M. Bostick, Elizabeth L. Barry
Publikováno v:
Cancer Prev Res (Phila)
Increased COX-2 and decreased 15-hydroxyprostaglandin dehydrogenase (15-HPGD) expression promote prostaglandin-mediated inflammation and colorectal carcinogenesis. Experimental studies suggest that vitamin D and calcium may inhibit these pathways, bu
Autor:
Shivani Soni, Joanne Xiu, Wu Zhang, Curtis Johnston, John L. Marshall, Francesca Battaglin, W. Michael Korn, Heinz-Josef Lenz, Joshua Millstein, Jingyuan Wang, Andreas Seeber, Richard M. Goldberg, Natsuko Kawanishi, Philip A. Philip, Yasmine Baca, Jimmy J. Hwang, Anthony F. Shields, Hiroyuki Arai
Publikováno v:
Mol Cancer Ther
Goblet cell carcinoid (GCC) is a distinct subtype of appendiceal neoplasm that exhibits unique clinical and pathologic features. We aimed to reveal the molecular profiles of GCC compared with other appendiceal tumors, such as adenocarcinomas and neur
Autor:
Liang Liang Shi, Fan Zhou, Gui Fang Xu, Chang Zheng, Bin Zhang, Yuzheng Zhuge, Lei Wang, Xiao Ping Zou, Yi Wang
Publikováno v:
Molecular Cancer Research. 18:1491-1499
The R-spondin family plays important roles in embryonic development, including in humans. However, information on the relationship between R-spondin2 and hepatocellular carcinoma (HCC) is lacking. This study aimed was to explore the mechanisms of R-s
Autor:
Thai H. Ho, Kenneth M. Boucher, Timothy Sargis, Jeffrey Mohlman, Deepika Sirohi, Christopher G. Wood, Adela Ramirez-Torres, Archana M. Agarwal, Lyska Emerson, Neeraj Agarwal, Pheroze Tamboli, Benjamin T. Spike, Rebecca S. S. Tidwell, Benjamin L. Maughan, Guillermina Garcia, Eric Jonasch, Sophie Cowman, Sheryl R. Tripp, Adam A. Olalde, Christopher J. Conley, Mei Yee Koh, Miekan A Stonhill, Neelima Kandula, Xian De Liu, Kanishka Sircar, Daniel Fuja, Jose A. Karam
Publikováno v:
Clin Cancer Res
Purpose: Clear cell renal cell carcinoma (ccRCC) is frequently associated with inactivation of the von Hippel–Lindau tumor suppressor, resulting in activation of HIF-1α and HIF-2α. The current paradigm, established using mechanistic cell-based st
Autor:
Neerav Shukla, Meera Hameed, Achim A. Jungbluth, Debyani Chakravarty, Ahmet Zehir, George Jour, Yoshiyuki Suehara, Anita S. Bowman, Denise Frosina, Takuo Hayashi, Emily K. Slotkin, Marc Ladanyi, Paul A. Meyers, John H. Healey, Deepu Alex, Khedoudja Nafa, Lu Wang, Sumit Middha
Publikováno v:
Clin Cancer Res
Purpose: Although multimodal chemotherapy has improved outcomes for patients with osteosarcoma, the prognosis for patients who present with metastatic and/or recurrent disease remains poor. In this study, we sought to define how often clinical genomi
Autor:
Neeraj Lal, Riyue Bao, Sandra Ventorin Von Zeidler, Arun Khattri, Helen R Valentine, Albert N. Menezes, Jean-Baptiste Cazier, Hisham Mehanna, Tanguy Y. Seiwert, Maha Ibrahim, Steven P. Lee, Jonathan J Deeks, Lucinda Archer, Daniel A. Tennant, Andrew D Beggs, Christopher Bagnall, Margaret Hartley, Nikolaos Batis, Kalu U.E. Ogbureke, Baksho Kaul, Jill Brooks, Gary Middleton, Jennifer L. Bryant, Catharine M L West, Gordon B. Ryan, Rachel Spruce, Benjamin E. Willcox
Publikováno v:
Clinical Cancer Research. 25:5315-5328
Purpose: Intratumoral hypoxia and immunity have been correlated with patient outcome in various tumor settings. However, these factors are not currently considered for treatment selection in head and neck cancer (HNC) due to lack of validated biomark