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Autor:
Erickson A, Carlos S. Moreno, Michelle M. Kouspou, Fred Saad, Michael S. Lewis, Onur Ertunc, Adeboye O. Osunkoya, Colm Morrissey, Bigler Sa, Tuomas Mirtti, Anne-Marie Mes-Masson, Stephen J. Freedland, Zhou X, Igor Vidal, Aud Svindland, Larry True, Tracy Jones, Ouellet, Mark Buzza, Wiley K, Tasken Ka, Pekka Taimen, Isla P. Garraway, Ariel H Achtman, Bova Sg, Angelo M. De Marzo, Bruce J. Trock, Dominique Trudel, Berge, Tarja Lamminen, Beatrice S. Knudsen
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 31:715-727
Background: The need to better understand the molecular underpinnings of the heterogeneous outcomes of patients with prostate cancer is a pressing global problem and a key research priority for Movember. To address this, the Movember Global Action Pl
Autor:
Emmy W. Verschuren, Pekka Paivinen, Sushil Tripathi, Ashwini S. Nagaraj, Eva Domenech-Moreno, Tomi P. Mäkelä, Kari Vaahtomeri, Iris P. L. Wong, Sarang S. Talwelkar, Marc Foretz, Benoit Viollet, Yan Yan, Yajing Gao
Publikováno v:
Clinical Cancer Research
Clinical Cancer Research, 2021, pp.clincanres.2049.2021. ⟨10.1158/1078-0432.CCR-21-2049⟩
Clinical Cancer Research, American Association for Cancer Research, 2021, pp.clincanres.2049.2021. ⟨10.1158/1078-0432.CCR-21-2049⟩
Clinical Cancer Research, 2021, pp.clincanres.2049.2021. ⟨10.1158/1078-0432.CCR-21-2049⟩
Clinical Cancer Research, American Association for Cancer Research, 2021, pp.clincanres.2049.2021. ⟨10.1158/1078-0432.CCR-21-2049⟩
Purpose: Mutations in STK11 (LKB1) occur in 17% of lung adenocarcinoma (LUAD) and drive a suppressive (cold) tumor immune microenvironment (TIME) and resistance to immunotherapy. The mechanisms underpinning the establishment and maintenance of a cold
Autor:
Sunil J. Advani, Hyunho Yoon, Rowan Ustoy, Mayra Yebra, Vipul R. Sheth, Sudeep Banerjee, Michael Heinrich, Christian M. Metallo, Joseph A. Aguilera, Sangkyu Noh, Scott M. Lippman, Razelle Kurzrock, Chih-Min Tang, Olivier Harismendy, Paul T. Fanta, Adam M. Burgoyne, Avi Kumar, Thekla Cordes, Shruti Bhargava, Sam Li, Jason K. Sicklick, Christopher L. Corless
Publikováno v:
Clin Cancer Res
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 28, iss 1
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 28, iss 1
Purpose: Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the gastrointestinal tract, with mutant succinate dehydrogenase (SDH) subunits (A–D) comprising less than 7.5% (i.e., 150–200/year) of new cases annually in the United S
Publikováno v:
Molecular Cancer Research. 20:11-29
In patients with cancer with metastatic disease, the rate of complete tumor response to systemic therapies is low, and residual lesions persist in the majority of patients due to early molecular adaptation in cancer cells. A growing body of evidence
Autor:
Kristyna Kupcova, Joanna Barankiewicz, Bjoern Chapuy, Anna Szumera-Ciećkiewicz, Anna Polak, Magdalena Winiarska, Joanna Domagala, Dorota Komar, Bartosz Pula, Magdalena Cybulska, Agnieszka Graczyk-Jarzynka, Ewa Jabłońska, Dominika Nowis, Michal Mikula, Michael R. Green, Krzysztof Brzózka, Michał Pawlak, Beata Pyrzynska, Filip Garbicz, Andrea Massimiliano Tomirotti, Malgorzata Statkiewicz, Monika Prochorec-Sobieszek, Kamil Bojarczuk, Aniela Golas, Ondrej Havranek, Jakub Golab, Marta Gajewska, Patryk Górniak, Maciej Szydlowski, Mariana Pacheco-Blanco, Emilia Bialopiotrowicz, Grzegorz Rymkiewicz, Przemyslaw Juszczynski
Publikováno v:
Cancer Research. 81:6029-6043
The family of PIM serine/threonine kinases includes three highly conserved oncogenes, PIM1, PIM2, and PIM3, which regulate multiple prosurvival pathways and cooperate with other oncogenes such as MYC. Recent genomic CRISPR-Cas9 screens further highli
Autor:
Andriy Zhylko, Marta Klopotowska, Zofia Pilch, Malgorzata Firczuk, Aleksander Slusarczyk, Malgorzata Bajor, Herman Netskar, Dariusz Plewczynski, Karl-Johan Malmberg, Agnieszka Goral, Iwona Baranowska, Agnieszka Graczyk-Jarzynka, Blanka Sharma, Kuba Retecki, Joanna Domagala, Radoslaw Zagozdzon, Mieszko Lachota, Michal Lazniewski, Karolina Soroczynska, Madison N. Temples, Katsiaryna Marhelava, Agnieszka Kraft, Kavita Ramji, Marta Krawczyk, Magdalena Winiarska
Publikováno v:
Cancer Immunology Research. 10:228-244
Oxidative stress, caused by the imbalance between reactive species generation and the dysfunctional capacity of antioxidant defenses, is one of the characteristic features of cancer. Here, we quantified hydrogen peroxide in the tumor microenvironment
Autor:
Jawairia Atif, Kimberly C. Wiegand, T. Michael Underhill, Jacqueline C.Y. Lai, Pauline Johnson, Spencer A. Freeman, Michael R. Gold, Kelly M. McNagny, Marie-Renée Blanchet, Arif A. Arif, Calvin D. Roskelley, Pamela Dean, Yu-Hsuan Huang
Publikováno v:
Molecular Cancer Research. 19:2096-2109
A rate-limiting step for circulating tumor cells to colonize distant organ sites is their ability to locate a microenvironmental niche that supports their survival and growth. This can be achieved by features intrinsic to the tumor cells and/or by th
Is Hodgkin Lymphoma Associated with Hepatitis B and C Viruses? A Systematic Review and Meta-analysis
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 30:2167-2175
Background: Apart from the Epstein–Barr virus (EBV), the etiology of the hematologic malignancy Hodgkin lymphoma (HL) is not well defined. Hepatitis B virus (HBV) and hepatitis C virus (HCV) are associated with some lymphoproliferative diseases wit
Autor:
James R. Hawley, Robert G. Bristow, Rupert Hugh-White, Giacomo Grillo, Christopher Arlidge, Paul C. Boutros, Michael Fraser, Theodorus van der Kwast, Ken Kron, Mathieu Lupien, Stanley Zhou
Publikováno v:
Cancer Research. 81:5833-5848
Prostate cancer is a heterogeneous disease whose progression is linked to genome instability. However, the impact of this instability on the noncoding genome and its three-dimensional organization to aid progression is unclear. Using primary benign a
Autor:
Lakshmi Muthuswamy, Ling Huang, Raul S. Gonzalez, Jonah Cohen, Senthil K. Muthuswamy, Catherine Conahan, Supraja Narasimhan, Tyler M. Berzin, Mandeep S. Sawhney, Andrea J. Bullock, Mary Linton B. Peters, Sofia Perea, Roger B. Davis, Benjamin Schlechter, Bruno Bockorny, Dipikaa Akshinthala, Robert J. Besaw, Mark P. Callery, Douglas K. Pleskow, Leo L. Tsai, Martin P. Smith, Christine Maria Lim, Manuel Hidalgo, Tara S. Kent, Joseph E. Grossman
Publikováno v:
Clin Cancer Res
Purpose: Pancreatic ductal adenocarcinoma (PDAC) remains a significant health issue. For most patients, there are no options for targeted therapy, and existing treatments are limited by toxicity. The HOPE trial (Harnessing Organoids for PErsonalized