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Autor:
Rita Mitra, Tatiana M. Oberyszyn, Xiaokui Mo, Madhavi Bhat, Sara B. Peters, Kai Lu, Sujit Basu, Partha Sarathi Dasgupta
Publikováno v:
Cancer Prev Res (Phila)
Although the role of dopamine (DA) in malignant tumors has been reported, its function in premalignant lesions is unknown. Herein we report that the stimulation of DA D2 receptors in endothelial cells in ultraviolet B (UVB)-induced cutaneous lesions
Autor:
Karolina Pavic, Taru Varila, Eliisa Löyttyniemi, Claire M. Lucas, Jukka Westermarck, Eleonora Makela, Maija Itälä-Remes, Tea Ammunét, Veli-Matti Kähäri, Richard E. Clark, Venkata Kumari Bachanaboyina, Urpu Salmenniemi, Laura L. Elo, Srikar G. Nagelli
Publikováno v:
CLINICAL CANCER RESEARCH
Purpose: Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an oncoprotein that inhibits the tumor suppressor PP2A-B56α. However, CIP2A mRNA variants remain uncharacterized. Here, we report the discovery of a CIP2A splicing variant, novel CIP2
Autor:
Marc T. Goodman, Susan J. Jordan, Kathryn L. Terry, Joellen M. Schildkraut, Kirsten B. Moysich, Jennifer A. Doherty, Penelope M. Webb, Karen McLean, Linda Titus, Anna H. Wu, Holly R. Harris, Alice W. Lee, Malcolm C. Pike, Celeste Leigh Pearce, Andrew Berchuck, Gillian E. Hanley, Minh Tung Phung, Francesmary Modugno, Bhramar Mukherjee, Kathleen R. Cho, Daniel W. Cramer
Publikováno v:
Cancer Epidemiol Biomarkers Prev
Background: Combined oral contraceptive use is associated with a decreased risk of invasive epithelial ovarian cancer (ovarian cancer). There is suggestive evidence of an inverse association between progestin-only contraceptive use and ovarian cancer
Autor:
Alexander Melamed, Melissa Beauchemin, Melissa K. Accordino, Jason D. Wright, Dawn L. Hershman, Jacob C Cogan, Rohit R. Raghunathan
Publikováno v:
Cancer Research. 81:GS3-08
Introduction Cancer surgery has been linked to chronic opioid use post-operatively, with up to 10% of patients continuing to fill opioid prescriptions beyond 3 months after surgery. However, previous studies have not compared post-operative opioid us
Autor:
Yu-Ming Shen, Dejan Juric, Murat Akdere, Aleix Prat, Hope S. Rugo, Stephen Chia, Christina Arce, Florence Lerebours, Nicholas C. Turner, Eva Ciruelos, Pamela Drullinsky, Rafael Villanueva Vazquez
Publikováno v:
Cancer Research. 81:PD2-07
Introduction: Mutations in PIK3CA, which encodes the α-isoform of phosphatidylinositol 3-kinase (PI3Kα), occur in ~40% of patients (pts) with HR+, HER2- ABC and can contribute to endocrine resistance. Alpelisib (ALP), a PI3Kα-selective inhibitor a
Autor:
Brenda J. Weigel, Keith D. Wilner, David Hall, Charles G. Minard, Jennifer Foster, Peter C. Adamson, Stacey L. Berg, Elizabeth Fox, Susan M. Blaney, Stephan D. Voss, Yael P. Mosse, Frank M. Balis
Publikováno v:
Clinical Cancer Research. 27:3543-3548
Purpose: Anaplastic lymphoma kinase (ALK) aberrations are a promising target for patients with neuroblastoma. We assessed the activity of first-generation ALK inhibitor crizotinib in patients with no known curative treatments and whose tumors harbore
Autor:
Wei Zhang, Lingmiao Kong, Zhongxue Feng, Denian Wang, Fei Xiao, Luping Huang, Hongyu Li, Haili Zhang, Huan Zhao, Heng Zhang, Min Li, Fei Liu, Yong-Gang Wei
Publikováno v:
Molecular Cancer Therapeutics. 20:284-295
Glioblastoma multiforme (GBM; grade IV glioma) is the most malignant type of primary brain tumor and is characterized by rapid proliferation and invasive growth. Intermedin (IMD) is an endogenous peptide belonging to the calcitonin gene-related pepti
Autor:
Britta M. Jacobsen, Jessica Finlay-Schultz, Reema Wahdan-Alaswad, Susan M. Edgerton, Bryan R. Haugen, Hyunmin Kim, Carol A. Sartorius, Elizabeth A. Wellberg, Ann D. Thor, Bolin Liu, Aik Choon Tan, Hiba Salem
Publikováno v:
Clinical Cancer Research. 27:585-597
Purpose: Thyroid disease is a frequent comorbidity in women with breast cancer, and many require thyroid hormone replacement therapy (THRT). We postulated that THRT has a deleterious clinical effect mechanistically through hormonal interactions, nucl
Autor:
Ramona Curpan, Balkees Abderrahman, Yue Chen, Debra A. Tonetti, Rui Xiong, Sean W. Fanning, Jay S. Hanspal, Charles E. Foulds, Ping Fan, Antrix Jain, Anna Malovannaya, Gregory R. J. Thatcher, V. Craig Jordan, Geoffrey L. Greene, Philipp Y. Maximov
Publikováno v:
Mol Cancer Ther
Patients with long-term estrogen-deprived breast cancer, after resistance to tamoxifen or aromatase inhibitors develops, can experience tumor regression when treated with estrogens. Estrogen's antitumor effect is attributed to apoptosis via the estro
Publikováno v:
Clin Cancer Res
Liver cancer is the fourth leading cause of cancer-related mortality worldwide and incidence is on the rise. Hepatocellular carcinoma (HCC) is the most common form of liver cancer, with a complex etiology and limited treatment options. The standard-o