Zobrazeno 71 - 80
of 131
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Autor:
Jean-Claude Souberbielle, Thierry Capiod, Arnaud Mejean, Stéphane Oudard, Nicolas Barry Delongchamps, Edouard Reyes-Gomez, Florence Boutillon, Natascha Pigat, Mélanie Viltard, Virginie Verkarre, Eve M. Lepicard, Vincent Goffin, Sophie Bernichtein, Philippe Camparo, Gérard Friedlander
Publikováno v:
Cancer Research. 77:355-365
Active surveillance has emerged as an alternative to immediate treatment for men with low-risk prostate cancer. Accordingly, identification of environmental factors that facilitate progression to more aggressive stages is critical for disease prevent
Autor:
Douglas Grossman, Scott R. Florell, Kenneth M. Boucher, Matthew Honeggar, Tong Liu, Pamela B. Cassidy, Sancy A. Leachman
Publikováno v:
Cancer Prevention Research. 10:36-44
Oxidative stress plays a role in UV-induced melanoma, which may arise from melanocytic nevi. We investigated whether oral administration of the antioxidant N-acetylcysteine (NAC) could protect nevi from oxidative stress in vivo in the setting of acut
Publikováno v:
Cancer Research. 76:7059-7071
Hepatocellular carcinoma is highly resistant to chemotherapy. Research data supported that cancer stem cells (CSC) may be responsible for the chemoresistance and strategies that suppress CSCs stemness could also inhibit the drug resistance. In this s
Autor:
Mariarosaria Di Tommaso, Camilla Fusi, Simone Li Puma, Alyn H. Morice, Pierangelo Geppetti, Romina Nassini, Ilaria M. Marone, Alessandro Terreni, Francesco De Logu, Laura R. Sadofsky, Serena Materazzi, Elisabetta Coppi, Tommaso Susini, Silvia Benemei, Raquel Tonello, Gloriano Moneti
Publikováno v:
Cancer Research. 76:7024-7035
Aromatase inhibitors (AI) induce painful musculoskeletal symptoms (AIMSS), which are dependent upon the pain transducing receptor TRPA1. However, as the AI concentrations required to engage TRPA1 in mice are higher than those found in the plasma of p
Autor:
Arina Riabinska, Miriam Rinneburger, Wenzel Vogel, Alexandra Florin, Mehmet Akyüz, Björn Schumacher, Reinhard Büttner, Christian Fritz, Sebastian Michels, Christiane Kümpers, Jürgen Thomale, David Maintz, Sven Perner, Mladen Jokic, Anne Offermann, Luka Ozretić, Maike Wittersheim, Thorsten Persigehl, Niklas Klümper, Anna Schmitt, Judith Eva Spiro, Michael Nowak, Martin Erkel, Hans Christian Reinhardt, Ignacija Vlasic, Jürgen Wolf, Daniela Welcker
Publikováno v:
Molecular Cancer Research. 14:1110-1123
KRAS-mutant lung adenocarcinoma is among the most common cancer entities and, in advanced stages, typically displays poor prognosis due to acquired resistance against chemotherapy, which is still largely based on cisplatin-containing combination regi
Autor:
Wen Jia Zuo, Zhi Ming Shao, Jiong Wu, Guang Yu Liu, Yi-Zhou Jiang, Gen Hong Di, Xin Hu, Y. Wang, Ke Da Yu, Xiao En Xu
Publikováno v:
Clinical Cancer Research. 22:4859-4869
Purpose: Somatic mutations in the tyrosine kinase domain of human epidermal growth factor receptor 2 (HER2) may be an alternative mechanism to HER2 activation and can affect the sensitivity toward HER2-targeted therapies. We aimed to investigate the
Autor:
Lukas C. Heukamp, William Pao, Helen Pasternack, Christian Becker, Kerstin Albus, Matthias Scheffler, Reinhard Buettner, Johannes M. Heuckmann, Alexandra Florin, Martin L. Sos, Andreas H. Scheel, Jana Fassunke, Martin Peifer, Thorsten Persigehl, Sabine Merkelbach-Bruse, Sebastian Michels, Marc Bos, Lynnette Fernandez-Cuesta, Janine Altmüller, Dennis Plenker, Jürgen Wolf, Lydia Meder, Sandra Ortiz-Cuaran, Johannes Berg, llona Dahmen, Michaela Angelika Ihle, Carina Heydt, Hongbin Ji, Rieke Fischer, Roman K. Thomas, Christian Müller, Peter Nuernberg, Sascha Ansén, Christine M. Lovly, Hans-Ulrich Schildhaus, Katharina König
Publikováno v:
Clinical Cancer Research. 22:4837-4847
Purpose: To identify novel mechanisms of resistance to third-generation EGFR inhibitors in patients with lung adenocarcinoma that progressed under therapy with either AZD9291 or rociletinib (CO-1686). Experimental Design: We analyzed tumor biopsies f
Autor:
Imad Shureiqi
Publikováno v:
Cancer Prevention Research. 11:1-3
Patients with familial adenomatous polyposis (FAP) have an increased risk of developing duodenal adenomas and adenocarcinomas. In previous trials, sulindac (a cyclooxygenase inhibitor) alone failed to significantly suppress duodenal tumorigenesis in
Autor:
Takatsugu Okegawa, Shuta Tomida, Suguru Hamada, Kikuo Nutahara, Hidetoshi Hayashi, Kazuko Sakai, Masato Terashima, Kazuto Nishio, Yu Nakamura, Yosuke Togashi, Yoshihiko Fujita, Eri Banno, Marco A. De Velasco, Hirokazu Nakahara
Publikováno v:
Molecular Cancer Therapeutics. 15:1988-1997
The prognosis for patients with advanced esophageal or head-and-neck squamous cell carcinoma (ESCC or HNSCC) remains poor, and the identification of additional oncogenes and their inhibitors is needed. In this study, we evaluated the sensitivities of
Autor:
Ellen Richmond, Eugene Trowers, Nicholas J. Shaheen, Blake A. Gibson, Gary Della'Zanna, Bhaskar Banerjee, Chiu Hsieh Hsu, Jessica A. Martinez, H-H. Sherry Chow
Publikováno v:
Cancer Prevention Research. 9:528-533
Prior research strongly implicates gastric acid and bile acids, two major components of the gastroesophageal refluxate, in the development of Barrett's esophagus and its pathogenesis. Ursodeoxycholic acid (UDCA), a hydrophilic bile acid, has been sho