Zobrazeno 1 - 10
of 190
pro vyhledávání: ''
Autor:
Pelin Gülizar Ersan, Hong Pei, Joel Linden, Sara Serra, Kim Phan, Qiping Zhao, Caglar Cekic, Renee Clift, H. Michael Shepard, Lei Huang, Michael J. LaBarre, Mertkaya Aras, Christopher D. Thanos, Lin Wang, Ozgur Sahin, Jessica Cowell, Xiaoming Li, Silvia Deaglio, Luz Marina Londoño, Ozge Saatci
Publikováno v:
Cancer Research. 81:3319-3332
Extracellular adenosine in tumors can suppress immune responses and promote tumor growth. Adenosine deaminase 2 (ADA2) converts adenosine into inosine. The role of ADA2 in cancer and whether it can target adenosine for cancer therapy has not been inv
Autor:
Samuel Achilefu, Michael H. Ross, Jingyu Xiang, Kristin A. Kwakwa, Elizabeth Cordell, Alison K. Esser, Vivek Sharma, Kristen Pagliai, Francesca Fontana, Jennifer L. Davis, Deborah J. Veis, Suzanne J. Bakewell, Xinming Su, Gregory M. Lanza, Katherine N. Weilbaecher, Gregory C. Fox, Christopher G. Maher, Jothilingam Sivapackiam, James A. J. Fitzpatrick, Yalin Xu, Ha X. Dang, Sheila A. Stewart
Publikováno v:
Mol Cancer Ther
Breast cancer bone metastases are common and incurable. Tumoral integrin β3 (β3) expression is induced through interaction with the bone microenvironment. Although β3 is known to promote bone colonization, its functional role during therapy of est
Autor:
Shawna Wall, Suzanne R. Thibodeaux, Vincent Hurez, T. L. Whiteside, Lishi Sun, Weiping Zou, Srilakshmi Pandeswara, Michael J. Brumlik, Tyler J. Curiel, Vinh Dao, Ilona Kryczek, Alvaro Padron, Brian B. Barnett, Benjamin J. Daniel, Justin M. Drerup
Publikováno v:
Clinical Cancer Research. 27:3661-3673
Purpose: Immunotherapy treats some cancers, but not ovarian cancer. Regulatory T cells (Tregs) impede anti-ovarian cancer immunity but effective human Treg-directed treatments are lacking. We tested Treg depletion with denileukin diftitox (DD) ± IFN
Autor:
Ki Hyun Yoo, Mi Hyeon Jang, Chang Hoon Cho, Alfredo Oliveros, Joseph A. Baur, Jason J. Tang, Mun Gyeong Bae, S. John Weroha, Jong Hoon Choi, Danielle Brogren, Xiaonan Hou, Mohammad Abdur Rashid, John R. Hawse, Ana Mia Corujo-Ramirez, Lindsey A Kirkeby
Publikováno v:
Cancer Res
Chemotherapy-induced cognitive impairment (CICI) is often reported as a neurotoxic side effect of chemotherapy. Although CICI has emerged as a significant medical problem, meaningful treatments are not currently available due to a lack of mechanistic
Autor:
Zhe Zhi, Lei Chen, Yiming Hu, Yongping Shao, Yan Wang, Yibo Ren, Jiankang Liu, Shujun Han, Yuwei Yan, Yan Zheng
Publikováno v:
Cancer Research. 81:2918-2929
The long noncoding RNA (lncRNA) SAMMSON is required for human melanoma cell growth and survival. However, whether SAMMSON regulates the response of mutant BRAF melanoma cells to RAF inhibitors remains unknown. In this work, we showed that SAMMSON is
Autor:
Krishanthan Vigneswaran, Shoeb Lallani, Renee Read, Nathaniel H. Boyd, Andrew B. Boucher, Se-Yeong Oh, Stewart G. Neill, Jeffrey J. Olson
Publikováno v:
Clin Cancer Res
Purpose: Glioblastomas (GBMs), neoplasms derived from glia and neuroglial progenitor cells, are the most common and lethal malignant primary brain tumors diagnosed in adults, with a median survival of 14 months. GBM tumorigenicity is often driven by
Autor:
Kristan H. Cleveland, Abdullah Shamim, Sherry Liang, Ying Huang, Mengbing Chen, Cyrus Parsa, Bradley T. Andresen, Ayaz Shahid, Robert Orlando
Publikováno v:
Cancer Prev Res (Phila)
Skin cancer is the most common malignancy worldwide and is rapidly rising in incidence, representing a significant public health challenge. The β-blocker, carvedilol, has shown promising effects in preventing skin cancer. However, as a potent β-blo
Autor:
Hilaire C. Lam, Long Zhang, Elizabeth P. Henske, Thomas Hougard, Clemens K. Probst, Harilaos Filippakis, Kosmas Kosmas, Ryan Rue, David J. Kwiatkowski, Vera P. Krymskaya, Andres Sanin, Elie W. Akl, Ji Wang, Andrii Kovalenko, Krinio Giannikou, John M. Asara
Publikováno v:
Cancer Res
Lymphangioleiomyomatosis is a rare destructive lung disease affecting primarily women and is the primary lung manifestation of tuberous sclerosis complex (TSC). In lymphangioleiomyomatosis, biallelic loss of TSC1/2 leads to hyperactivation of mTORC1
Autor:
Takahiro Kodama, Yuta Myojin, Daisuke Motooka, Yu Sato, Ayumu Taguchi, Ryotaro Sakamori, Kazuki Maesaka, Satoshi Tanaka, Tetsuo Takehara, Kazuyoshi Ohkawa, Hayato Hikita, Tomohide Tatsumi, Yoshito Hayashi, Hidetoshi Eguchi, Yuichi Abe, Eiji Mita
Publikováno v:
Clinical Cancer Research. 27:1150-1161
Purpose: Hepatocellular carcinoma (HCC) is characterized by high intertumor heterogeneity of genetic drivers. Two multitarget tyrosine kinase inhibitors (TKI), lenvatinib and sorafenib, are used as standard-of-care chemotherapeutics in patients with
Autor:
Paul Zolkind, Gavin P. Dunn, Ann Marie Egloff, Erica K. Barnell, Ravindra Uppaluri, Obi L. Griffith, Tenny Mudianto, Tusar Giri, Rachel S. Riley, Malachi Griffith, Jason Webb, Zachary L. Skidmore, Douglas Adkins, Katie M. Campbell, Ibrahim Ozgenc
Publikováno v:
Clin Cancer Res
Purpose: In a head and neck squamous cell carcinoma (HNSCC) “window of opportunity” clinical trial, we reported that trametinib reduced MEK-Erk1/2 activation and resulted in tumor responses in a subset of patients. Here, we investigated resistanc