Zobrazeno 1 - 10
of 82
pro vyhledávání: ''
Autor:
Sung Chul Lim, Youngnam Cho, Y. J. Kim, Seungmin Kang, Kyu Min Kim, Moon-Chang Baek, Keon Wook Kang, Miso Park, Ju Hyun Bae, Sung Baek Jeong, Jin Ki Kim, Dae Won Jun, Yong June Choi, Seung-Hyun Lee, Jiwon Kim, Wankyu Kim, HyungJae Lee, Sung Yun Cho
Publikováno v:
Cancer Research. 81:3539-3553
Extracellular vesicles (EV) in the tumor microenvironment have emerged as crucial mediators that promote proliferation, metastasis, and chemoresistance. However, the role of circulating small EVs (csEV) in cancer progression remains poorly understood
Autor:
Samuel Achilefu, Michael H. Ross, Jingyu Xiang, Kristin A. Kwakwa, Elizabeth Cordell, Alison K. Esser, Vivek Sharma, Kristen Pagliai, Francesca Fontana, Jennifer L. Davis, Deborah J. Veis, Suzanne J. Bakewell, Xinming Su, Gregory M. Lanza, Katherine N. Weilbaecher, Gregory C. Fox, Christopher G. Maher, Jothilingam Sivapackiam, James A. J. Fitzpatrick, Yalin Xu, Ha X. Dang, Sheila A. Stewart
Publikováno v:
Mol Cancer Ther
Breast cancer bone metastases are common and incurable. Tumoral integrin β3 (β3) expression is induced through interaction with the bone microenvironment. Although β3 is known to promote bone colonization, its functional role during therapy of est
Autor:
Krishanthan Vigneswaran, Shoeb Lallani, Renee Read, Nathaniel H. Boyd, Andrew B. Boucher, Se-Yeong Oh, Stewart G. Neill, Jeffrey J. Olson
Publikováno v:
Clin Cancer Res
Purpose: Glioblastomas (GBMs), neoplasms derived from glia and neuroglial progenitor cells, are the most common and lethal malignant primary brain tumors diagnosed in adults, with a median survival of 14 months. GBM tumorigenicity is often driven by
Autor:
Lei Bi, Fuqiong Zhou, Peng Meng, Bo Tang, Yidan Ren, Yunshan Wang, Yu-Cui Jiang, Weiping Chen, Qin Wang, Chuanxin Wang, Maoxiao Feng, Yuli Wang, Feiyan Chen, Qinlian Jiao, Lutao Du
Publikováno v:
Cancer Research. 81:2015-2028
Hepatocellular carcinoma (HCC) contains a subset of cancer stem cells (CSC) that cause tumor recurrence, metastasis, and chemical resistance. Histone deacetylase 11 (HDAC11) mediates diverse immune functions and metabolism, yet little is known about
Autor:
Zahid H. Siddik, Bangxing Hong, Uksha Saini, David E. Cohn, Anil K. Sood, Guangsheng Pei, Guangan He, Zhongming Zhao, Yuanqing Yan, Karuppaiyah Selvendiran, Valerie Chapa, Balveen Kaur, Ji Young Yoo, Puneet Modgil
Publikováno v:
Clin Cancer Res
Purpose:Here we investigated the impact of oncolytic herpes simplex virus (HSV) treatment on cisplatin sensitivity of platinum-resistant ovarian cancer, and the impact of the combination on immunotherapy.Experimental Design:Therapeutic efficacy of th
Autor:
Britta M. Jacobsen, Jessica Finlay-Schultz, Reema Wahdan-Alaswad, Susan M. Edgerton, Bryan R. Haugen, Hyunmin Kim, Carol A. Sartorius, Elizabeth A. Wellberg, Ann D. Thor, Bolin Liu, Aik Choon Tan, Hiba Salem
Publikováno v:
Clinical Cancer Research. 27:585-597
Purpose: Thyroid disease is a frequent comorbidity in women with breast cancer, and many require thyroid hormone replacement therapy (THRT). We postulated that THRT has a deleterious clinical effect mechanistically through hormonal interactions, nucl
Autor:
Selvarangan Ponnazhagan, Jonathan A. Hensel, Yong Wang, Jessy S. Deshane, Hong Wang, Reading Ashton, Vinayak Khattar, Joo Hyoung Lee
Publikováno v:
Mol Cancer Ther
Complexities in treating breast cancer with bone metastasis are enhanced by a vicious protumorigenic pathology, involving a shift in skeletal homeostasis toward aggressive osteoclast activity and polarization of immune cells supporting tumor growth a
Autor:
Xinxin Song, Ivet Bahar, Zhuan Zhou, Hongchun Li, Xinghua Lu, Yifan Xue, Mien Chie Hung, Guido Kroemer, Oliver Kepp, Yong Wan
Publikováno v:
Cancer Discov
Despite widespread utilization of immunotherapy, treating immune-cold tumors has proved to be a challenge. Here, we report that expression of the immune checkpoint molecule B7-H4 is prevalent among immune-cold triple-negative breast cancers (TNBC), w
Publikováno v:
Clin Cancer Res
Purpose: Statins are cholesterol-depleting drugs used to treat patients with hypercholesterolemia. Preclinically, statins disrupt trafficking of receptors present at the cell membrane. Membrane receptors, defined as tumor biomarkers and therapeutic t
Autor:
Giorgos C. Karakousis, Mark R. Middleton, Gloria E. Marino, Xiaowei Xu, Andrea Marshall, Richard Colling, Neera Maroo, Yash Chhabra, Olivia Espinosa, Gretchen M. Alicea, Mitchell Fane, Amanpreet Kaur, Brett L. Ecker, Marie R. Webster, Nicholas Coupe, Ashani T. Weeraratna, Pippa Corrie, Stephen M. Douglass, Leticia Campo
Publikováno v:
Clin Cancer Res
Purpose: Angiogenesis is thought to be critical for tumor metastasis. However, inhibiting angiogenesis using antibodies such as bevacizumab (Avastin), has had little impact on melanoma patient survival. We have demonstrated that both angiogenesis and