Zobrazeno 1 - 10
of 183
pro vyhledávání: ''
Autor:
Samuel Achilefu, Michael H. Ross, Jingyu Xiang, Kristin A. Kwakwa, Elizabeth Cordell, Alison K. Esser, Vivek Sharma, Kristen Pagliai, Francesca Fontana, Jennifer L. Davis, Deborah J. Veis, Suzanne J. Bakewell, Xinming Su, Gregory M. Lanza, Katherine N. Weilbaecher, Gregory C. Fox, Christopher G. Maher, Jothilingam Sivapackiam, James A. J. Fitzpatrick, Yalin Xu, Ha X. Dang, Sheila A. Stewart
Publikováno v:
Mol Cancer Ther
Breast cancer bone metastases are common and incurable. Tumoral integrin β3 (β3) expression is induced through interaction with the bone microenvironment. Although β3 is known to promote bone colonization, its functional role during therapy of est
Autor:
Zahid H. Siddik, Bangxing Hong, Uksha Saini, David E. Cohn, Anil K. Sood, Guangsheng Pei, Guangan He, Zhongming Zhao, Yuanqing Yan, Karuppaiyah Selvendiran, Valerie Chapa, Balveen Kaur, Ji Young Yoo, Puneet Modgil
Publikováno v:
Clin Cancer Res
Purpose:Here we investigated the impact of oncolytic herpes simplex virus (HSV) treatment on cisplatin sensitivity of platinum-resistant ovarian cancer, and the impact of the combination on immunotherapy.Experimental Design:Therapeutic efficacy of th
Autor:
Marc Ladanyi, Bob T. Li, Jennifer Kherani, Elena Ivanova, Arrien A. Bertram, Ezra Y. Rosen, Elaine M. Kelley, Jieun Son, Marina S.D. Milan, Jaclyn F. Hechtman, Romel Somwar, Kevin Ebata, Alexander Drilon, Melissa Lynne Johnson, Sarah E. Clifford, Jenna E. Scanlon, Barry S. Taylor, Geoffrey R. Oxnard, Eric Gladstone, S Michael Rothenberg, Elizabeth Olek, Monika A. Davare, Binoj Nair, Pasi A. Jänne, Mika Lin, Lynette M. Sholl, Morana Vojnic, Dahlia Henry
Publikováno v:
Clin Cancer Res
Purpose: The RET proto-oncogene encodes a receptor tyrosine kinase that is activated by gene fusion in 1%–2% of non–small cell lung cancers (NSCLC) and rarely in other cancer types. Selpercatinib is a highly selective RET kinase inhibitor that ha
Autor:
Selvarangan Ponnazhagan, Jonathan A. Hensel, Yong Wang, Jessy S. Deshane, Hong Wang, Reading Ashton, Vinayak Khattar, Joo Hyoung Lee
Publikováno v:
Mol Cancer Ther
Complexities in treating breast cancer with bone metastasis are enhanced by a vicious protumorigenic pathology, involving a shift in skeletal homeostasis toward aggressive osteoclast activity and polarization of immune cells supporting tumor growth a
Autor:
Xinxin Song, Ivet Bahar, Zhuan Zhou, Hongchun Li, Xinghua Lu, Yifan Xue, Mien Chie Hung, Guido Kroemer, Oliver Kepp, Yong Wan
Publikováno v:
Cancer Discov
Despite widespread utilization of immunotherapy, treating immune-cold tumors has proved to be a challenge. Here, we report that expression of the immune checkpoint molecule B7-H4 is prevalent among immune-cold triple-negative breast cancers (TNBC), w
Autor:
Federica Piccioni, Michael S. Cuoco, Aviv Regev, Vincent A. Miller, Samuel S. Freeman, Nan Lin, Nikhil Wagle, Seth A. Wander, Kailey J. Kowalski, David E. Root, Pingping Mao, Jon Chung, Adrienne G. Waks, Eric P. Winer, Utthara Nayar, Orit Rozenblatt-Rosen, Justin Kusiel, Ofir Cohen, Jorge E. Buendia-Buendia, Pedro Exman
Publikováno v:
Clinical Cancer Research. 26:5974-5989
Purpose:To identify clinically relevant mechanisms of resistance to ER-directed therapies in ER+ breast cancer.Experimental Design:We conducted a genome-scale functional screen spanning 10,135 genes to investigate genes whose overexpression confer re
Autor:
Sanford D. Markowitz, Joel N. Saltzman, Zhenghe Wang, Martina L. Veigl, Shaveta Vinayak, Smitha S. Krishnamurthi, Yan Xu, Zhanwen Du, Yujun Hao, Gino Cioffi, J. Eva Selfridge, Jennifer R. Eads, Xiujing Feng, Neal J. Meropol, Janet Wang, Yicheng Chen, Jill S. Barnholtz-Sloan, David L. Bajor, Shashank Gorityala, Yiqing Zhao, Ronald A. Conlon
Publikováno v:
Cancer Research. 80:4815-4827
PIK3CA encodes the p110α catalytic subunit of PI3K and is frequently mutated in human cancers, including ∼30% of colorectal cancer. Oncogenic mutations in PIK3CA render colorectal cancers more dependent on glutamine. Here we report that the glutam
Autor:
Giorgos C. Karakousis, Mark R. Middleton, Gloria E. Marino, Xiaowei Xu, Andrea Marshall, Richard Colling, Neera Maroo, Yash Chhabra, Olivia Espinosa, Gretchen M. Alicea, Mitchell Fane, Amanpreet Kaur, Brett L. Ecker, Marie R. Webster, Nicholas Coupe, Ashani T. Weeraratna, Pippa Corrie, Stephen M. Douglass, Leticia Campo
Publikováno v:
Clin Cancer Res
Purpose: Angiogenesis is thought to be critical for tumor metastasis. However, inhibiting angiogenesis using antibodies such as bevacizumab (Avastin), has had little impact on melanoma patient survival. We have demonstrated that both angiogenesis and
Autor:
Charlotte Fribbens, Lucy Kilburn, Stephen R. D. Johnston, William J. Gradishar, Mitch Dowsett, Judith M Bliss, Aman U. Budzar, John F.R. Robertson, Claire Swift, Nicholas C. Turner, Stephen Chia, Gaia Schiavon, Isaac Garcia-Murillas, Matthew Beaney, Martine Piccart
Publikováno v:
Clinical Cancer Research. 26:5172-5177
Purpose: ESR1 mutations are acquired frequently in hormone receptor–positive metastatic breast cancer after prior aromatase inhibitors. We assessed the clinical utility of baseline ESR1 circulating tumor DNA (ctDNA) analysis in the two phase III ra
Autor:
Shimin Wang, Pu Cheng, Qiannan Ding, Xuan Shao, Lu Cheng, Jun Pan, Guoming Hu, Liming Huang, Zhou Jiang, Jian Huang
Publikováno v:
Cancer Immunology Research. 8:1273-1286
The tumor microenvironment induces immunosuppression via recruiting and expanding suppressive immune cells such as regulatory T cells (Treg) to promote cancer progression. In this study, we documented that tumor-infiltrating CD73+ γδTregs were the