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Publikováno v:
Annals of Palliative Medicine. 10:899-908
Glioblastoma in the elderly (>65 years of age) is associated with shorter overall survival (OS) than in younger patients. Best practice recommendations for elderly patients, especially those with borderline or poor performance status, remain a subjec
Autor:
Sara Ferrer-Suay, Pilar Codoñer-Franch, Miguel Tortajada-Girbés, Joaquín Carrasco-Luna, Eulalia Alonso-Iglesias
Publikováno v:
Translational Pediatrics. 10:103-111
Background Vitamin D has gone from being just one vitamin to being an important prohormone with multiple effects on different tissue types. The mechanism of action of the active form or calcitriol is mediated by the intracellular vitamin D receptor (
Autor:
Arjun Sahgal, Eric L. Chang, Samuel T. Chao, Simon S. Lo, Caryn Wujanto, Balamurugan Vellayappan
Publikováno v:
Annals of Palliative Medicine. 10:936-952
Radiotherapy (RT) has been widely used in the management of benign and malignant brain tumors for decades. However, complications can develop as a result of adjacent structures being exposed to radiation. As such, careful selection of patients and de
Autor:
Hirohisa Yoshizawa, Naoya Matsumoto, Hiroshi Tanaka, Satoru Miura, Kazuhiko Ito, Masaaki Okajima, Akira Iwashima, Kazuhiro Sato, Takashi Ishida, Masato Makino, Kosuke Ichikawa, Tetsuya Abe, Toshiaki Kikuchi, Satoshi Watanabe
Publikováno v:
Transl Lung Cancer Res
Background Afatinib has shown clinical benefits in patients with non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations. Many patients treated with afatinib experience skin or gastrointestinal toxicity. However
Publikováno v:
Gland Surg
BACKGROUND: Our study aimed to compare the efficacy and safety of anthracycline plus taxane (AT)-based neoadjuvant chemotherapy (NAC) with or without cyclophosphamide in the treatment of breast cancer. METHODS: We searched PubMed, Embase, Web of Scie
Autor:
Hideaki Kato, Ho Namkoong, Nobuyuki Horita, Takeshi Kaneko, Yu Hara, Risa Ebina-Shibuya, Nobuaki Kobayashi
Publikováno v:
J Thorac Dis
Background Although the US government approved hydroxychloroquine (HCQ) and chloroquine (CQ) for hospitalized coronavirus disease 19 (COVID-19) patients, some studies denied efficacy of HCQ and CQ. We aimed to evaluate HCQ/CQ treatment for COVID-19.
Autor:
Naoko Shimada, Ryo Ko, Ryo Koyama, Koichi Azuma, Chiyo K. Imamura, Takaaki Tokito, Hidenobu Ishii, Takehito Shukuya, Kazuhiko Yamada, Kazuhisa Takahashi
Publikováno v:
Transl Lung Cancer Res
Background Afatinib is a second-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). Combination therapies with first-generation EGFR-TKIs and bevacizumab have been reported to prolong progression-free survival (PFS). H
Publikováno v:
Annals of Palliative Medicine. 10:479-483
Background Post-hemorrhoidectomy pain is common, usually temporary, and responsive to analgesics. However, some patients experience prolonged, intractable anal pain, which is refractory to conventional analgesics and adversely effects quality of life
Autor:
Yuetian Yu, Zhi-Chun Gu, Hong-Yao Shi, Yang-Xi Liu, Min Cui, Han Zhong, Zai-Li Zhang, Ke-Jia Le
Publikováno v:
Transl Androl Urol
Background Facing the global threat of emerging resistance to antibiotics, tigecycline, a novel glycylcycline antibiotic, is developed to against multidrug-resistant pathogens, but not recommended for the treatment of complicated urinary tract infect
Autor:
Shingo Hatakeyama, Senji Hoshi, Shigeto Ishidoya, Sadafumi Kawamura, Norihiko Tsuchiya, Masahiro Takahashi, Tomonori Habuchi, Shintaro Narita, Chikara Ohyama, Jiro Shimoda, Koji Mitsuzuka, Akihiro Ito, Takuma Narita, Yoichi Arai, Toshihiko Sakurai, Toshiaki Kawaguchi
Publikováno v:
Transl Androl Urol
Background The clinical benefit of the combined androgen blockade (CAB) therapy over luteinizing hormone-releasing hormone analog (LH-RHa) monotherapy for hormone naive metastatic prostate cancer (mHNPC) is unclear. Therefore, we retrospectively comp