Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Nellie Y. Loh"'
Autor:
Feng-Chih Kuo, Matt J. Neville, Rugivan Sabaratnam, Agata Wesolowska-Andersen, Daniel Phillips, Laura B.L. Wittemans, Andrea D. van Dam, Nellie Y. Loh, Marijana Todorčević, Nathan Denton, Katherine A. Kentistou, Peter K. Joshi, Constantinos Christodoulides, Claudia Langenberg, Philippe Collas, Fredrik Karpe, Katherine E. Pinnick
Publikováno v:
Cell Reports, Vol 40, Iss 4, Pp 111136- (2022)
Summary: Mechanisms governing regional human adipose tissue (AT) development remain undefined. Here, we show that the long non-coding RNA HOTAIR (HOX transcript antisense RNA) is exclusively expressed in gluteofemoral AT, where it is essential for ad
Externí odkaz:
https://doaj.org/article/d702a76facc64b9ca3d2316c0276c1b2
Publikováno v:
Nutrients, Vol 14, Iss 24, p 5259 (2022)
Obesity and upper-body fat distribution are independent, cardiometabolic risk factors but whether they also display comparable associations with cancer risk is unknown. We investigated the causal relationships between body mass index (BMI) and BMI-ad
Externí odkaz:
https://doaj.org/article/4cb7c48f7f304f2688b326dd2381f903
Autor:
Nellie Y. Loh, James E. N. Minchin, Katherine E. Pinnick, Manu Verma, Marijana Todorčević, Nathan Denton, Julia El-Sayed Moustafa, John P. Kemp, Celia L. Gregson, David M. Evans, Matt J. Neville, Kerrin S. Small, Mark I. McCarthy, Anubha Mahajan, John F. Rawls, Fredrik Karpe, Constantinos Christodoulides
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Genetic variants at the RSPO3 locus are associated with waist-to-hip ratio (adjusted for BMI). Here, Loh et al. describe two independent RSPO3 signals that associate with body fat distribution, perform fine-mapping and explore the function of RSPO3 i
Externí odkaz:
https://doaj.org/article/63058441426945e38b49d38d86552953
Autor:
Sian E Piret, Christopher T Esapa, Caroline M Gorvin, Rosie Head, Nellie Y Loh, Olivier Devuyst, Gethin Thomas, Steve D M Brown, Matthew Brown, Peter Croucher, Roger Cox, Rajesh V Thakker
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45217 (2012)
Chronic kidney disease (CKD) is characterized by renal fibrosis that can lead to end-stage renal failure, and studies have supported a strong genetic influence on the risk of developing CKD. However, investigations of the underlying molecular mechani
Externí odkaz:
https://doaj.org/article/c9ed65b4c08843b79c4663219b1b6885
Autor:
Christopher T Esapa, Sian E Piret, M Andrew Nesbit, Nellie Y Loh, Gethin Thomas, Peter I Croucher, Matthew A Brown, Steve D M Brown, Roger D Cox, Rajesh V Thakker
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167916 (2016)
Non-syndromic kyphosis is a common disorder that is associated with significant morbidity and has a strong genetic involvement; however, the causative genes remain to be identified, as such studies are hampered by genetic heterogeneity, small familie
Externí odkaz:
https://doaj.org/article/5be3fc2482074313a0a2de925720ba76
Autor:
Nellie Y Loh, Liz Bentley, Henrik Dimke, Sjoerd Verkaart, Paolo Tammaro, Caroline M Gorvin, Michael J Stechman, Bushra N Ahmad, Fadil M Hannan, Sian E Piret, Holly Evans, Ilaria Bellantuono, Tertius A Hough, William D Fraser, Joost G J Hoenderop, Frances M Ashcroft, Steve D M Brown, René J M Bindels, Roger D Cox, Rajesh V Thakker
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55412 (2013)
Hypercalciuria is a major cause of nephrolithiasis, and is a common and complex disorder involving genetic and environmental factors. Identification of genetic factors for monogenic forms of hypercalciuria is hampered by the limited availability of l
Externí odkaz:
https://doaj.org/article/398083a269454e2e838e54531e91aaa4