Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Mauricio J. Reginato"'
Autor:
Emily M. Esquea, Lorela Ciraku, Riley G. Young, Jessica Merzy, Alexandra N. Talarico, Nusaiba N. Ahmed, Mangalam Karuppiah, Anna Ramesh, Adam Chatoff, Claudia V. Crispim, Adel A. Rashad, Simon Cocklin, Nathaniel W. Snyder, Joris Beld, Nicole L. Simone, Mauricio J. Reginato, Alexej Dick
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Breast cancer brain metastasis (BCBM) typically results in an end-stage diagnosis and is hindered by a lack of brain-penetrant drugs. Tumors in the brain rely on the conversion of acetate to acetyl-CoA by the enzyme acetyl-CoA synthetase 2 (ACSS2), a
Externí odkaz:
https://doaj.org/article/4ae2b15c3c5446188251b5c916b863e7
Autor:
Giang Le Minh, Emily M. Esquea, Tejsi T. Dhameliya, Jessica Merzy, Mi-Hye Lee, Lauren E. Ball, Mauricio J. Reginato
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionBreast tumor development is regulated by a sub-population of breast cancer cells, termed cancer stem-like cells (CSC), which are capable of self-renewing and differentiating, and are involved in promoting breast cancer invasion, metastasi
Externí odkaz:
https://doaj.org/article/73855a2ba67f41b5b4633d4a716e2cac
Publikováno v:
BMC Biology, Vol 17, Iss 1, Pp 1-14 (2019)
Abstract Altered metabolism and deregulated cellular energetics are now considered a hallmark of all cancers. Glucose, glutamine, fatty acids, and amino acids are the primary drivers of tumor growth and act as substrates for the hexosamine biosynthet
Externí odkaz:
https://doaj.org/article/28554646374447969a2d20a67e92cc3a
Autor:
Gregory P. Botta, Maximilian Reichert, Mauricio J. Reginato, Steffen Heeg, Anil K. Rustgi, Peter I. Lelkes
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 4, Pp 359-372 (2013)
Pancreatic ductal adenocarcinoma (PDAC) commonly contains a mutation in K-RasG12D and is characterized by a desmoplastic reaction composed of deregulated, proliferating cells embedded in an abnormal extracellular matrix (ECM). Our previous observatio
Externí odkaz:
https://doaj.org/article/81a32830787146f08ff9edeeb28a413b