Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Marju Orho-Melander"'
Autor:
Filip Ottosson, Francesco Russo, Anna Abrahamsson, Nadia MacSween, Julie Courraud, Kristin Skogstrand, Olle Melander, Ulrika Ericson, Marju Orho-Melander, Arieh S. Cohen, Jakob Grove, Preben Bo Mortensen, David M. Hougaard, Madeleine Ernst
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background The prevalence of autism in Denmark has been increasing, reaching 1.65% among 10-year-old children, and similar trends are seen elsewhere. Although there are several factors associated with autism, including genetic, environmental
Externí odkaz:
https://doaj.org/article/c2ef8d3921514b3ea5ecafec64670785
Autor:
Helena Grauen Larsen, Jiangming Sun, Marketa Sjögren, Yan Borné, Gunnar Engström, Peter Nilsson, Marju Orho-Melander, Isabel Goncalves, Jan Nilsson, Olle Melander, Alexandru Schiopu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The receptor for advanced glycation endproducts (RAGE) has pro-inflammatory and pro-atherogenic effects. Low plasma levels of soluble RAGE (sRAGE), a decoy receptor for RAGE ligands, have been associated with increased risk for major adverse
Externí odkaz:
https://doaj.org/article/b96798e6060345dba3b6beb9bdf3cdb3
Autor:
Thomas Svensson, Akiko Kishi Svensson, Mariusz Kitlinski, Gunnar Engström, Jan Nilsson, Marju Orho-Melander, Peter M. Nilsson, Olle Melander
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background The molecular pathways linking short and long sleep duration with incident diabetes mellitus (iDM) and incident coronary heart disease (iCHD) are not known. We aimed to identify circulating protein patterns associated with sleep d
Externí odkaz:
https://doaj.org/article/e94637a1425049549b5402b1cc2ce8ec
Publikováno v:
JHEP Reports, Vol 6, Iss 8, Pp 101105- (2024)
Background & Aims: It is unclear to what extent lifestyle and genetic factors affect the incidence of chronic liver disease (CLD) in the general population and if lifestyle affects CLD independently of underlying cardiometabolic perturbations and gen
Externí odkaz:
https://doaj.org/article/e901d5f974da4b3fbb0ef828f806eb9c
Autor:
Filip Ottosson, Gunnar Engström, Marju Orho‐Melander, Olle Melander, Peter M. Nilsson, Madeleine Johansson
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 9 (2024)
Background Increased aortic stiffness (arteriosclerosis) is associated with early vascular aging independent of age and sex. The underlying mechanisms of early vascular aging remain largely unexplored in the general population. We aimed to investigat
Externí odkaz:
https://doaj.org/article/be429236e28b458690ffe89b9e3f8bb4
Autor:
Gabriel Baldanzi, Sergi Sayols-Baixeras, Elin Ekblom-Bak, Örjan Ekblom, Koen F. Dekkers, Ulf Hammar, Diem Nguyen, Shafqat Ahmad, Ulrika Ericson, Daniel Arvidsson, Mats Börjesson, Peter J. Johanson, J. Gustav Smith, Göran Bergström, Lars Lind, Gunnar Engström, Johan Ärnlöv, Beatrice Kennedy, Marju Orho-Melander, Tove Fall
Publikováno v:
EBioMedicine, Vol 100, Iss , Pp 104989- (2024)
Summary: Background: Previous population-based studies investigating the relationship between physical activity and the gut microbiota have relied on self-reported activity, prone to reporting bias. Here, we investigated the associations of accelerom
Externí odkaz:
https://doaj.org/article/d78b6d330b5c4bc2be81691e63e84dd1
Autor:
Alexandru Schiopu, Harry Björkbacka, Gayathri Narasimhan, Bi Juin Loong, Gunnar Engström, Olle Melander, Marju Orho-Melander, Jan Nilsson
Publikováno v:
Annals of Medicine, Vol 55, Iss 2 (2023)
AbstractBackground There is an unmet clinical need for novel therapies addressing the residual risk in patients receiving guideline preventive therapy for coronary heart disease. Experimental studies have identified a pro-atherogenic role of the oxid
Externí odkaz:
https://doaj.org/article/66eb19c3bf4e4aecb9cafddfeec12b8b
Autor:
Stanley Teleka, Marju Orho-Melander, Fredrik Liedberg, Olle Melander, Karin Jirström, Tanja Stocks
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract There is substantial genetic predisposition to bladder cancer (BC). Recently, blood pressure (BP) was positively associated with BC risk in men, but the potential interaction with genetic susceptibility for BC is unknown. We investigated a w
Externí odkaz:
https://doaj.org/article/038fb0fc799a4b38a012f39a296985ca
Autor:
Koen F. Dekkers, Sergi Sayols-Baixeras, Gabriel Baldanzi, Christoph Nowak, Ulf Hammar, Diem Nguyen, Georgios Varotsis, Louise Brunkwall, Nynne Nielsen, Aron C. Eklund, Jacob Bak Holm, H. Bjørn Nielsen, Filip Ottosson, Yi-Ting Lin, Shafqat Ahmad, Lars Lind, Johan Sundström, Gunnar Engström, J. Gustav Smith, Johan Ärnlöv, Marju Orho-Melander, Tove Fall
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Abstract Human gut microbiota produce a variety of molecules, some of which enter the bloodstream and impact health. Conversely, dietary or pharmacological compounds may affect the microbiota before entering the circulation. Characterization of these
Externí odkaz:
https://doaj.org/article/703b87b4299246bbb8f3952ed1090c9b
Autor:
Parsa Akbari, Olukayode A. Sosina, Jonas Bovijn, Karl Landheer, Jonas B. Nielsen, Minhee Kim, Senem Aykul, Tanima De, Mary E. Haas, George Hindy, Nan Lin, Ian R. Dinsmore, Jonathan Z. Luo, Stefanie Hectors, Benjamin Geraghty, Mary Germino, Lampros Panagis, Prodromos Parasoglou, Johnathon R. Walls, Gabor Halasz, Gurinder S. Atwal, Regeneron Genetics Center, DiscovEHR Collaboration, Marcus Jones, Michelle G. LeBlanc, Christopher D. Still, David J. Carey, Alice Giontella, Marju Orho-Melander, Jaime Berumen, Pablo Kuri-Morales, Jesus Alegre-Díaz, Jason M. Torres, Jonathan R. Emberson, Rory Collins, Daniel J. Rader, Brian Zambrowicz, Andrew J. Murphy, Suganthi Balasubramanian, John D. Overton, Jeffrey G. Reid, Alan R. Shuldiner, Michael Cantor, Goncalo R. Abecasis, Manuel A. R. Ferreira, Mark W. Sleeman, Viktoria Gusarova, Judith Altarejos, Charles Harris, Aris N. Economides, Vincent Idone, Katia Karalis, Giusy Della Gatta, Tooraj Mirshahi, George D. Yancopoulos, Olle Melander, Jonathan Marchini, Roberto Tapia-Conyer, Adam E. Locke, Aris Baras, Niek Verweij, Luca A. Lotta
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Fat distribution is associated with cardiometabolic disease, although it has been less well studied than overall obesity. In a multiancestry exome-sequencing study, the authors identified predicted loss-of-function mutations in INHBE associated with
Externí odkaz:
https://doaj.org/article/9f24eb7300be4033aaf87fbf13407526