Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Manuela Cervelli"'
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Polyamines (PA) are polycations with pleiotropic functions in cellular physiology and pathology. In particular, PA have been involved in the regulation of cell homeostasis and proliferation participating in the control of fundamental process
Externí odkaz:
https://doaj.org/article/8b5210a18d4c4c22b775c22290d978dc
Autor:
Graziano Rilievo, Massimiliano Magro, Federica Tonolo, Alessandro Cecconello, Lavinia Rutigliano, Aura Cencini, Simone Molinari, Maria Luisa Di Paolo, Cristian Fiorucci, Marianna Nicoletta Rossi, Manuela Cervelli, Fabio Vianello
Publikováno v:
Biomolecules, Vol 13, Iss 12, p 1800 (2023)
Protein–nanoparticle hybridization can ideally lead to novel biological entities characterized by emerging properties that can sensibly differ from those of the parent components. Herein, the effect of ionic strength on the biological functions of
Externí odkaz:
https://doaj.org/article/e7dced5e08ff482b85f62a7f9d87811b
Autor:
Clara Perrone, Silvia Pomella, Matteo Cassandri, Michele Pezzella, Stefano Giuliani, Tecla Gasperi, Antonella Porrazzo, Anna Alisi, Anna Pastore, Silvia Codenotti, Alessandro Fanzani, Giovanni Barillari, Libenzio Adrian Conti, Biagio De Angelis, Concetta Quintarelli, Paolo Mariottini, Franco Locatelli, Francesco Marampon, Rossella Rota, Manuela Cervelli
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Rhabdomyosarcoma (RMS) is a pediatric myogenic soft tissue sarcoma that includes fusion-positive (FP) and fusion-negative (FN) molecular subtypes. FP-RMS expresses PAX3-FOXO1 fusion protein and often shows dismal prognosis. FN-RMS shows cytogenetic a
Externí odkaz:
https://doaj.org/article/ef551ba1bce14ec79854aa47d12b0851
Autor:
Giulia Nordio, Francesco Piazzola, Giorgio Cozza, Monica Rossetto, Manuela Cervelli, Anna Minarini, Filippo Basagni, Elisa Tassinari, Lisa Dalla Via, Andrea Milelli, Maria Luisa Di Paolo
Publikováno v:
Molecules, Vol 28, Iss 17, p 6329 (2023)
Monoamine oxidases (MAOs) are well-known pharmacological targets in neurological and neurodegenerative diseases. However, recent studies have revealed a new role for MAOs in certain types of cancer such as glioblastoma and prostate cancer, in which t
Externí odkaz:
https://doaj.org/article/c91776a6f04d46d0b17a0f15fcc4c8ee
Autor:
Emiliano Fratini, Marco Salvemini, Fabrizio Lombardo, Maurizio Muzzi, Marco Molfini, Silvia Gisondi, Elia Roma, Veronica D’Ezio, Tiziana Persichini, Tecla Gasperi, Paolo Mariottini, Andrea Di Giulio, Marco Alberto Bologna, Manuela Cervelli, Emiliano Mancini
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-24 (2021)
Abstract Background Meloidae (blister beetles) are known to synthetize cantharidin (CA), a toxic and defensive terpene mainly stored in male accessory glands (MAG) and emitted outward through reflex-bleeding. Recent progresses in understanding CA bio
Externí odkaz:
https://doaj.org/article/45494e0c09fb41a3b44e684c4063333b
Autor:
Clara Perrone, Silvia Pomella, Matteo Cassandri, Michele Pezzella, Giuseppe Maria Milano, Marta Colletti, Cristina Cossetti, Giulia Pericoli, Angela Di Giannatale, Emmanuel de Billy, Maria Vinci, Stefania Petrini, Francesco Marampon, Concetta Quintarelli, Riccardo Taulli, Josep Roma, Soledad Gallego, Simona Camero, Paolo Mariottini, Manuela Cervelli, Roberta Maestro, Lucio Miele, Biagio De Angelis, Franco Locatelli, Rossella Rota
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Rhabdomyosarcoma (RMS) is a pediatric myogenic soft tissue sarcoma. The Fusion-Positive (FP) subtype expresses the chimeric protein PAX3-FOXO1 (P3F) while the Fusion-Negative (FN) is devoid of any gene translocation. FP-RMS and metastatic FN-RMS are
Externí odkaz:
https://doaj.org/article/ee3525baf2b04329b1397817076f26b7
Autor:
Roberta Ceci, Guglielmo Duranti, Stefano Giuliani, Marianna Nicoletta Rossi, Ivan Dimauro, Stefania Sabatini, Paolo Mariottini, Manuela Cervelli
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 10986 (2022)
A central feature of the skeletal muscle is its ability to regenerate through the activation, by environmental signals, of satellite cells. Once activated, these cells proliferate as myoblasts, and defects in this process profoundly affect the subseq
Externí odkaz:
https://doaj.org/article/1a55f6d729244c8db353b95194a7e278
Autor:
Manuela Cervelli, Monica Averna, Laura Vergani, Marco Pedrazzi, Sarah Amato, Cristian Fiorucci, Marianna Nicoletta Rossi, Guido Maura, Paolo Mariottini, Chiara Cervetto, Manuela Marcoli
Publikováno v:
Biomedicines, Vol 10, Iss 7, p 1756 (2022)
In mammalian cells, the content of polyamines is tightly regulated. Polyamines, including spermine, spermidine and putrescine, are involved in many cellular processes. Spermine oxidase specifically oxidizes spermine, and its deregulated activity has
Externí odkaz:
https://doaj.org/article/20a9c8ee125942df89898798335b1f65
Autor:
Emiliano Fratini, Marianna Nicoletta Rossi, Lucrezia Spagoni, Alessandra Riccieri, Emiliano Mancini, Fabio Polticelli, Marco Alberto Bologna, Paolo Mariottini, Manuela Cervelli
Publikováno v:
Biomolecules, Vol 12, Iss 7, p 988 (2022)
Protease inhibitors are widely studied since the unrestricted activity of proteases can cause extensive organ lesions. In particular, elastase activity is involved in the pathophysiology of acute lung injury, for example during SARS-CoV-2 infection,
Externí odkaz:
https://doaj.org/article/cb366e47a3964b20b162de9f65b71cca
Autor:
Maria Luisa Di Paolo, Manuela Cervelli, Paolo Mariottini, Alessia Leonetti, Fabio Polticelli, Michela Rosini, Andrea Milelli, Filippo Basagni, Rina Venerando, Enzo Agostinelli, Anna Minarini
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 740-752 (2019)
Fourteen polyamine analogues, asymmetric or symmetric substituted spermine (1–9) or methoctramine (10–14) analogues, were evaluated as potential inhibitors or substrates of two enzymes of the polyamine catabolic pathway, spermine oxidase (SMOX) a
Externí odkaz:
https://doaj.org/article/1dbc6fd3202f4f33b7717030344a779d