Zobrazeno 1 - 10
of 14
pro vyhledávání: '"James R. Fuchs"'
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-19 (2023)
Abstract Retrosynthesis is a procedure where a target molecule is transformed into potential reactants and thus the synthesis routes can be identified. Recently, computational approaches have been developed to accelerate the design of synthesis route
Externí odkaz:
https://doaj.org/article/480fb60db89f4f459d39885a7d8ea005
Autor:
Debasmita Mukherjee, Srija Chakraborty, Lena Bercz, Liliana D’Alesio, Jessica Wedig, Molly A. Torok, Timothy Pfau, Hannah Lathrop, Shrina Jasani, Abigail Guenther, Jake McGue, Daniel Adu-Ampratwum, James R. Fuchs, Timothy L. Frankel, Maciej Pietrzak, Stacey Culp, Anne M. Strohecker, Aleksander Skardal, Thomas A. Mace
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107408- (2023)
Summary: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with high metastasis and therapeutic resistance. Activating transcription factor 4 (ATF4), a master regulator of cellular stress, is exploited by cancer cells to survive. Prior
Externí odkaz:
https://doaj.org/article/a4781aeac6144f15a1769afbae4e87be
Autor:
Yosra A. Helmy, Dipak Kathayat, Gary Closs, Jr, Katie Galgozy, James R. Fuchs, Gireesh Rajashekara
Publikováno v:
Poultry Science, Vol 102, Iss 4, Pp 102543- (2023)
ABSTRACT: Avian pathogenic E. coli (APEC), a causative agent of colibacillosis, is associated with high mortality and morbidity which results in severe economic losses to the poultry industry worldwide. APEC can be transmitted to humans through the c
Externí odkaz:
https://doaj.org/article/c86c18046e8e48ba8ddaec67476f2467
Autor:
Amrita Salvi, Alexandria N. Young, Andrew C. Huntsman, Melissa R. Pergande, Melissa A. Korkmaz, Rathnayake A. Rathnayake, Brittney K. Mize, A. Douglas Kinghorn, Xiaoli Zhang, Kiira Ratia, Markus Schirle, Jason R. Thomas, Scott M. Brittain, Claude Shelton, Leslie N. Aldrich, Stephanie M. Cologna, James R. Fuchs, Joanna E. Burdette
Publikováno v:
Cell Death and Disease, Vol 13, Iss 1, Pp 1-13 (2022)
Abstract PHY34 is a synthetic small molecule, inspired by a compound naturally occurring in tropical plants of the Phyllanthus genus. PHY34 was developed to have potent in vitro and in vivo anticancer activity against high grade serous ovarian cancer
Externí odkaz:
https://doaj.org/article/e4c4de122bed46cdace434fd84397a5c
Autor:
Daniel Adu-Ampratwum, Yuhan Pan, Pratibha C. Koneru, Janet Antwi, Ashley C. Hoyte, Jacques Kessl, Patrick R. Griffin, Mamuka Kvaratskhelia, James R. Fuchs, Ross C. Larue
Publikováno v:
ACS Omega, Vol 7, Iss 5, Pp 4482-4491 (2022)
Externí odkaz:
https://doaj.org/article/15cbe867ebee4b9a9097b7772e0faf03
Autor:
Stephanie M. Bester, Daniel Adu-Ampratwum, Arun S. Annamalai, Guochao Wei, Lorenzo Briganti, Bridget C. Murphy, Reed Haney, James R. Fuchs, Mamuka Kvaratskhelia
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT Lenacapavir (LEN) is a long-acting, highly potent HIV-1 capsid (CA) inhibitor. The evolution of viral variants under the genetic pressure of LEN identified Q67H, N74D, and Q67H/N74D CA substitutions as the main resistance associated mutation
Externí odkaz:
https://doaj.org/article/de881a26d80643a3a99ed9b309fbea63
Autor:
Yosra A. Helmy, Dipak Kathayat, Loic Deblais, Vishal Srivastava, Gary Closs, Robert J. Tokarski, Oluwatosin Ayinde, James R. Fuchs, Gireesh Rajashekara
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 3 (2022)
ABSTRACT Avian pathogenic Escherichia coli (APEC) associated with colibacillosis results in high morbidity and mortality, and severe economic losses to the poultry industry. APEC is a zoonotic pathogen and can infect humans through contaminated poult
Externí odkaz:
https://doaj.org/article/9a256d555ac74e5bbf188b4b8115d7ed
Autor:
M. Shamim Hasan Zahid, Monica M. Johnson, Robert J. Tokarski, II, Abhay R. Satoskar, James R. Fuchs, Eric M. Bachelder, Kristy M. Ainslie
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 10, Iss , Pp 125-132 (2019)
Visceral leishmaniasis (VL) is associated with treatment complications due to the continued growth of resistant parasites toward currently available pathogen-directed therapeutics. To limit the emergence and combat resistant parasites there is a need
Externí odkaz:
https://doaj.org/article/716bfe9e4ea0424e8cf76cbbdedd1a0b
Autor:
Jasmine Moshiri, Darpan Kaur, Chido M. Hambira, Jenna L. Sandala, Jacob A. Koopman, James R. Fuchs, John S. Gunn
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Biofilm formation is a common strategy utilized by bacterial pathogens to establish persistence in a host niche. Salmonella enterica serovar Typhi, the etiological agent of Typhoid fever, relies on biofilm formation in the gallbladder to chronically
Externí odkaz:
https://doaj.org/article/b89874455b3e4f0d8b60f3c1cf7ac92d
Autor:
Jianqiang Wu, Vincent W. Keng, Deanna M. Patmore, Jed J. Kendall, Ami V. Patel, Edwin Jousma, Walter J. Jessen, Kwangmin Choi, Barbara R. Tschida, Kevin A.T. Silverstein, Danhua Fan, Eric B. Schwartz, James R. Fuchs, Yuanshu Zou, Mi-Ok Kim, Eva Dombi, David E. Levy, Gang Huang, Jose A. Cancelas, Anat O. Stemmer-Rachamimov, Robert J. Spinner, David A. Largaespada, Nancy Ratner
Publikováno v:
Cell Reports, Vol 14, Iss 8, Pp 1979-1990 (2016)
To identify genes and signaling pathways that initiate Neurofibromatosis type 1 (NF1) neurofibromas, we used unbiased insertional mutagenesis screening, mouse models, and molecular analyses. We mapped an Nf1-Stat3-Arid1b/β-catenin pathway that becom
Externí odkaz:
https://doaj.org/article/b85859bc4dea43bd98344313076ad5bb