Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Duncan T. Odom"'
Autor:
Martina Rimoldi, Ning Wang, Jilin Zhang, Diego Villar, Duncan T. Odom, Jussi Taipale, Paul Flicek, Maša Roller
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-22 (2024)
Abstract Background DNA methylation is an important epigenetic modification which has numerous roles in modulating genome function. Its levels are spatially correlated across the genome, typically high in repressed regions but low in transcription fa
Externí odkaz:
https://doaj.org/article/cf477576d182432584630d6c8a3a968c
Autor:
Jasper Panten, Tobias Heinen, Christina Ernst, Nils Eling, Rebecca E. Wagner, Maja Satorius, John C. Marioni, Oliver Stegle, Duncan T. Odom
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Cis-genetic effects are key determinants of transcriptional divergence in discrete tissues and cell types. However, how cis- and trans-effects act across continuous trajectories of cellular differentiation in vivo is poorly understood. Here,
Externí odkaz:
https://doaj.org/article/0aabafdc3a6a47a1b3c45ad1b7b7f851
Autor:
Maša Roller, Ericca Stamper, Diego Villar, Osagie Izuogu, Fergal Martin, Aisling M. Redmond, Raghavendra Ramachanderan, Louise Harewood, Duncan T. Odom, Paul Flicek
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-43 (2021)
Abstract Background To investigate the mechanisms driving regulatory evolution across tissues, we experimentally mapped promoters, enhancers, and gene expression in the liver, brain, muscle, and testis from ten diverse mammals. Results The regulatory
Externí odkaz:
https://doaj.org/article/c5c4fa97e4e54a19aaaedaf410287007
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-24 (2020)
Abstract Background The introduction of novel CTCF binding sites in gene regulatory regions in the rodent lineage is partly the effect of transposable element expansion, particularly in the murine lineage. The exact mechanism and functional impact of
Externí odkaz:
https://doaj.org/article/7852eff7c2554055be7936bec70e00c6
Autor:
Cristina Sisu, Paul Muir, Adam Frankish, Ian Fiddes, Mark Diekhans, David Thybert, Duncan T. Odom, Paul Flicek, Thomas M. Keane, Tim Hubbard, Jennifer Harrow, Mark Gerstein
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Pseudogenes are key markers of genome remodelling processes. Here the authors present genome-wide annotation of the pseudogenes in the mouse reference genome and 18 inbred mouse strains, update human pseudogene annotations, and characterise the trans
Externí odkaz:
https://doaj.org/article/bc3bf2d1f24949899d576df8a558a91e
Autor:
Lovorka Stojic, Aaron T. L. Lun, Patrice Mascalchi, Christina Ernst, Aisling M. Redmond, Jasmin Mangei, Alexis R. Barr, Vicky Bousgouni, Chris Bakal, John C. Marioni, Duncan T. Odom, Fanni Gergely
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Long noncoding RNAs (lncRNAs) regulate key steps of cell division. Here, the authors perform a comprehensive RNAi imaging screen targeting more than 2,000 human lncRNAs, and suggest a role of chromatin-associated linc00899 in regulation of cell divis
Externí odkaz:
https://doaj.org/article/0822bd0027864a7a9eecc223dca2b6f0
Autor:
Elissavet Kentepozidou, Sarah J. Aitken, Christine Feig, Klara Stefflova, Ximena Ibarra-Soria, Duncan T. Odom, Maša Roller, Paul Flicek
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-19 (2020)
Abstract Background CTCF binding contributes to the establishment of a higher-order genome structure by demarcating the boundaries of large-scale topologically associating domains (TADs). However, despite the importance and conservation of TADs, the
Externí odkaz:
https://doaj.org/article/291fa0f00ad04f14bfde9e67e60009ab
Autor:
Minjun Yang, Mattias Vesterlund, Ioannis Siavelis, Larissa H. Moura-Castro, Anders Castor, Thoas Fioretos, Rozbeh Jafari, Henrik Lilljebjörn, Duncan T. Odom, Linda Olsson, Naveen Ravi, Eleanor L. Woodward, Louise Harewood, Janne Lehtiö, Kajsa Paulsson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
High hyperploidy is a common feature in childhood B-cell precursor acute lymphoblastic leukemia. Here, the authors perform proteogenomic and Hi-C analyses of this leukemia and the ETV6/RUNX1 subtype and show that CTCF and cohesin expression are low i
Externí odkaz:
https://doaj.org/article/8fb5db51725140f997f862673ee0cf51
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
The transcriptional regulation of murine spermatogenesis is not well understood. Here, the authors use single-cell and bulk RNA-Sequencing of juvenile and adult mice to characterise somatic and germ cell development, and chromatin profile the X chrom
Externí odkaz:
https://doaj.org/article/bc7e9055ff6e43a8ad2daf0f91f1d334
Publikováno v:
Cell Reports, Vol 30, Iss 5, Pp 1319-1328.e6 (2020)
Summary: Transcription factor binding to enhancer and promoter regions critical for homeostatic adult gene activation is established during development. To understand how cell-specific gene expression patterns are generated, we study the developmenta
Externí odkaz:
https://doaj.org/article/50293e7decda4e81a7213e313f796aae