Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Douglas Lauffenburger"'
Autor:
Carolin Loos, Margherita Coccia, Arnaud M. Didierlaurent, Ahmed Essaghir, Jonathan K. Fallon, Douglas Lauffenburger, Corinne Luedemann, Ashlin Michell, Robbert van der Most, Alex Lee Zhu, Galit Alter, Wivine Burny
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-15 (2023)
Abstract The mechanisms by which antibodies confer protection vary across vaccines, ranging from simple neutralization to functions requiring innate immune recruitment via Fc-dependent mechanisms. The role of adjuvants in shaping the maturation of an
Externí odkaz:
https://doaj.org/article/5c9b578e54b84227946ca060096c90b3
Autor:
Bronwyn M. Gunn, Ryan P. McNamara, Lianna Wood, Sabian Taylor, Anush Devadhasan, Wenyu Guo, Jishnu Das, Avlant Nilsson, Amy Shurtleff, Sheri Dubey, Michael Eichberg, Todd J. Suscovich, Erica Ollmann Saphire, Douglas Lauffenburger, Beth-Ann Coller, Jakub K. Simon, Galit Alter
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112402- (2023)
Summary: The 2013 Ebola epidemic in Central and West Africa heralded the emergence of wide-spread, highly pathogenic viruses. The successful recombinant vector vaccine against Ebola (rVSVΔG-ZEBOV-GP) will limit future outbreaks, but identifying mech
Externí odkaz:
https://doaj.org/article/90fb68c6d5eb4c3e91f4e4eb1c155d42
Autor:
Jonathan D. Herman, Chuangqi Wang, Carolin Loos, Hyunah Yoon, Johanna Rivera, M. Eugenia Dieterle, Denise Haslwanter, Rohit K. Jangra, Robert H. Bortz, Katharine J. Bar, Boris Julg, Kartik Chandran, Douglas Lauffenburger, Liise-anne Pirofski, Galit Alter
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Convalescent plasma (CP) has been trialed as a therapy for SARS-CoV-2 symptoms, but its heterogenous nature precludes uniform outcomes. Here the authors perform deep profiling of CP, as well as plasma of CP recipients before and after transfer, to fi
Externí odkaz:
https://doaj.org/article/5214fb7ba9d240e5bff4799c7e668657
Autor:
Kathryn A. Bowman, Daniel Stein, Sally Shin, Kathie G. Ferbas, Nicole H. Tobin, Colin Mann, Stephanie Fischinger, Erica Ollmann Saphire, Douglas Lauffenburger, Anne W. Rimoin, Grace Aldrovandi, Galit Alter
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT Despite the robust immunogenicity of SARS-CoV-2 mRNA vaccines, emerging data have revealed enhanced neutralizing antibody and T cell cross-reactivity among individuals that previously experienced COVID-19, pointing to a hybrid immune advanta
Externí odkaz:
https://doaj.org/article/8a45ba113daa4c21b8a0a4d081bbefd5
Autor:
Krystle K.Q. Yu, Stephanie Fischinger, Malisa T. Smith, Caroline Atyeo, Deniz Cizmeci, Caitlin R. Wolf, Erik D. Layton, Jennifer K. Logue, Melissa S. Aguilar, Kiel Shuey, Carolin Loos, Jingyou Yu, Nicholas Franko, Robert Y. Choi, Anna Wald, Dan H. Barouch, David M. Koelle, Douglas Lauffenburger, Helen Y. Chu, Galit Alter, Chetan Seshadri
Publikováno v:
JCI Insight, Vol 6, Iss 6 (2021)
Comorbid medical illnesses, such as obesity and diabetes, are associated with more severe COVID-19, hospitalization, and death. However, the role of the immune system in mediating these clinical outcomes has not been determined. We used multiparamete
Externí odkaz:
https://doaj.org/article/b5959002267547a3b33b4f8d69ee17df
Autor:
Rasmus Offersen, Wen-Han Yu, Eileen P. Scully, Boris Julg, Zelda Euler, Saheli Sadanand, Dario Garcia-Dominguez, Lu Zheng, Thomas A. Rasmussen, Madeleine F. Jennewein, Caitlyn Linde, Jessica Sassic, Giuseppe Lofano, Selena Vigano, Kathryn E. Stephenson, Stephanie Fischinger, Todd J. Suscovich, Mathias Lichterfeld, Douglas Lauffenburger, Erik S. Rosenberg, Todd Allen, Marcus Altfeld, Richelle C. Charles, Lars Østergaard, Martin Tolstrup, Dan H. Barouch, Ole S. Søgaard, Galit Alter
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108502- (2020)
Summary: Changes in antibody glycosylation are linked to inflammation across several diseases. Alterations in bulk antibody galactosylation can predict rheumatic flares, act as a sensor for immune activation, predict gastric cancer relapse, track wit
Externí odkaz:
https://doaj.org/article/708b5101342c4ee5a05e68d73b2077b4
Autor:
Carolin Loos, Caroline Atyeo, Stephanie Fischinger, John Burke, Matthew D. Slein, Hendrik Streeck, Douglas Lauffenburger, Edward T. Ryan, Richelle C. Charles, Galit Alter
Publikováno v:
mSphere, Vol 5, Iss 5 (2020)
ABSTRACT The novel coronavirus, SARS-coronavirus (CoV)-2 (SARS-CoV-2), has caused over 17 million infections in just a few months, with disease manifestations ranging from largely asymptomatic infection to critically severe disease. The remarkable sp
Externí odkaz:
https://doaj.org/article/d055acc5916d4b90b38ae24bc3bbd195
PKCδ localization at the membrane increases matrix traction force dependent on PLCγ1/EGFR signaling.
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77434 (2013)
INTRODUCTION:During wound healing, fibroblasts initially migrate into the wound bed and later contract the matrix. Relevant mediators of transcellular contractility revealed by systems analyses are protein kinase c delta/myosin light chain-2 (PKCδ/M
Externí odkaz:
https://doaj.org/article/6f47c3e0dcd943f6acf0ee63d3aeabd7
Autor:
Miles Miller, Marc Hafner, Eduardo Sontag, Noah Davidsohn, Sairam Subramanian, Priscilla E M Purnick, Douglas Lauffenburger, Ron Weiss
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 7, p e1002579 (2012)
Synthetic biology efforts have largely focused on small engineered gene networks, yet understanding how to integrate multiple synthetic modules and interface them with endogenous pathways remains a challenge. Here we present the design, system integr
Externí odkaz:
https://doaj.org/article/cc318bec4fa94c7eaecd9cad0262fd1a
Autor:
Ken S Lau, Tinghu Zhang, Krystle R Kendall, Douglas Lauffenburger, Nathanael S Gray, Kevin M Haigis
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41343 (2012)
K-RAS mutation poses a particularly difficult problem for cancer therapy. Activating mutations in K-RAS are common in cancers of the lung, pancreas, and colon and are associated with poor response to therapy. As such, targeted therapies that abrogate
Externí odkaz:
https://doaj.org/article/688da89a803a48f88b33c09f67d79515