Zobrazeno 1 - 10
of 63
pro vyhledávání: '"D. Tew"'
Autor:
G.-O. F. Gowers, S. M. Chee, D. Bell, L. Suckling, M. Kern, D. Tew, D. W. McClymont, T. Ellis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
SCRaMbLE can lead to great genetic diversity for product biosynthesis but is limited by screening methods. Here the authors develop a rapid workflow using automation, ultra-fast LC/MS and barcoded nanopore sequencing to identify best performing strai
Externí odkaz:
https://doaj.org/article/0a521b41817846ec8416988a01e7bb8f
Autor:
Jeffrey P. Townsend, Hayley B. Hassler, April D. Lamb, Pratha Sah, Aia Alvarez Nishio, Cameron Nguyen, Alexandra D. Tew, Alison P. Galvani, Alex Dornburg
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTSuccessive waves of infection by SARS-CoV-2 have left little doubt that this virus will transition to an endemic disease. Foreknowledge of when to expect seasonal surges is crucial for healthcare and public health decision-making. However, th
Externí odkaz:
https://doaj.org/article/5f2ee80989614ff4afac3241cb961543
Autor:
Leilei Zhang, Claudia M. Ludden, Alexander J. Cullen, Kenneth D. Tew, André Luís Branco de Barros, Danyelle M. Townsend
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 167, Iss , Pp 115459- (2023)
In this mini-review, we discuss the role of NF-κB, a proinflammatory transcription factor, in the expression of genes involved in inflammation, proliferation, and apoptosis pathways, and link it with prognosis of various human cancers, particularly
Externí odkaz:
https://doaj.org/article/6a59c99872434363a3b346b863248ec3
Autor:
Jie Zhang, Zhi-wei Ye, Paramita Chakraborty, Zhenwu Luo, John Culpepper, Muhammad Aslam, Leilei Zhang, Katarina Johansson, Jesper Z. Haeggström, Jianqiang Xu, Magnus Olsson, Danyelle M. Townsend, Shikhar Mehrotra, Ralf Morgenstern, Kenneth D. Tew
Publikováno v:
Pharmacological Research, Vol 196, Iss , Pp 106899- (2023)
While recent targeted and immunotherapies in malignant melanoma are encouraging, most patients acquire resistance, implicating a need to identify additional drug targets to improve outcomes. Recently, attention has been given to pathways that regulat
Externí odkaz:
https://doaj.org/article/5d9d42b0e955458aadc407c65b31b648
Autor:
Aslam M. A. Mazari, Leilei Zhang, Zhi-Wei Ye, Jie Zhang, Kenneth D. Tew, Danyelle M. Townsend
Publikováno v:
Biomolecules, Vol 13, Iss 4, p 688 (2023)
In humans, the cytosolic glutathione S-transferase (GST) family of proteins is encoded by 16 genes presented in seven different classes. GSTs exhibit remarkable structural similarity with some overlapping functionalities. As a primary function, GSTs
Externí odkaz:
https://doaj.org/article/cfe3261347ef461da534d32f3bcb5e60
Akademický článek
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Publikováno v:
BioTechniques, Vol 32, Iss 3, Pp 636-647 (2002)
Externí odkaz:
https://doaj.org/article/46e687a84a2546f8b1ddb073425b3db3
Publikováno v:
International Journal of Cell Biology, Vol 2012 (2012)
S-Glutathionylation of cysteine residues within target proteins is a posttranslational modification that alters structure and function. We have shown that S-glutathionylation of protein disulfide isomerase (PDI) disrupts protein folding and leads to
Externí odkaz:
https://doaj.org/article/f65469732f0f4f74a95c8c1ad9ed547f
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e14151 (2010)
PABA/NO is a diazeniumdiolate that acts as a direct nitrogen monoxide (NO) donor and is in development as an anticancer drug. Its mechanism of action and effect on cells is not yet fully understood.We used HPLC and mass spectrometry to identify a pri
Externí odkaz:
https://doaj.org/article/34a99e3e0e71441db484db2a33c59e76
Akademický článek
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