Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Amy W. Lasek"'
Autor:
Valeria C. Torres Irizarry, Bing Feng, Xiaohua Yang, Nirali Patel, Sarah Schaul, Lucas Ibrahimi, Hui Ye, Pei Luo, Leslie Carrillo-Sáenz, Penghua Lai, Maya Kota, Devin Dixit, Chunmei Wang, Amy W. Lasek, Yanlin He, Pingwen Xu
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Estrogens promote binge alcohol drinking and contribute to sex differences in alcohol use disorder. However, the mechanisms are largely unknown. This study aims to test if estrogens act on 5-hydroxytryptamine neurons in the dorsal raphe nucl
Externí odkaz:
https://doaj.org/article/87df6b4e68bc4617815407d3080e63f1
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/2910c0f8cf03495bb18140feaa7d76c9
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
Compulsive alcohol drinking is a key symptom of alcohol use disorder (AUD) that is particularly resistant to treatment. An understanding of the biological factors that underly compulsive drinking will allow for the development of new therapeutic targ
Externí odkaz:
https://doaj.org/article/3d2f468164df424abfa912a7601e0cf3
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 14 (2022)
Externí odkaz:
https://doaj.org/article/f3d558cddf964f12bd631c59af21789b
Autor:
Wei-Yang Chen, Hu Chen, Kana Hamada, Eleonora Gatta, Ying Chen, Huaibo Zhang, Jenny Drnevich, Harish R. Krishnan, Mark Maienschein-Cline, Dennis R. Grayson, Subhash C. Pandey, Amy W. Lasek
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Alcohol use disorder (AUD) is highly comorbid with depression. Withdrawal from chronic alcohol drinking results in depression and understanding brain molecular mechanisms that drive withdrawal-related depression is important for finding new
Externí odkaz:
https://doaj.org/article/4f01af3adbe34d83bd69eca16d8ef2c2
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase recently implicated in biochemical, physiological, and behavioral responses to ethanol. Thus, manipulation of ALK signaling may represent a novel approach to treating alcohol use disorder
Externí odkaz:
https://doaj.org/article/1f08f47c705244ea90825573b36bcfe3
Autor:
Daniel Rafferty, Luana Martins de Carvalho, Mason Sutter, Katlyn Heneghan, Victoria Nelson, Megan Leitner, Charlotte Bolch, Amy W Lasek, Prasanth Puthanveetil
Publikováno v:
Redox Experimental Medicine, Vol 2023, Iss 1, Pp 1-16 (2023)
Binge drinking is a growing health concern among all age groups. The ability of individuals to handle ethanol in their systems differs not due to differences in enzyme expression but also due to other factors. Vital organs including brain, liver, hea
Externí odkaz:
https://doaj.org/article/51bb9b4c9cba44568f712762fce9cc61
Autor:
Cassandre Coles, Amy W Lasek
Publikováno v:
Neuroscience Insights, Vol 16 (2021)
Alcohol use disorder is associated with pathophysiological changes in the dopaminergic system. Orthodenticle homeobox 2 (OTX2) is a transcription factor important for the development of dopaminergic neurons residing in the ventral tegmental area (VTA
Externí odkaz:
https://doaj.org/article/f9219f592092400da7bcba544ad57013
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187698 (2017)
Gender differences in psychiatric disorders such as addiction may be modulated by the steroid hormone estrogen. For instance, 17β-estradiol (E2), the predominant form of circulating estrogen in pre-menopausal females, increases ethanol consumption,
Externí odkaz:
https://doaj.org/article/4d356314f72c4085a36e394b0cd1e57f
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34559 (2012)
Pavlovian fear conditioning is an associative learning paradigm in which mice learn to associate a neutral conditioned stimulus with an aversive unconditioned stimulus. In this study, we demonstrate a novel role for the transcriptional regulator Lmo4
Externí odkaz:
https://doaj.org/article/ed4a7bd5666b4b5bbcc7975037716210