Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Alex M. Jaeger"'
Autor:
Ava P. Amini, Jesse D. Kirkpatrick, Cathy S. Wang, Alex M. Jaeger, Susan Su, Santiago Naranjo, Qian Zhong, Christina M. Cabana, Tyler Jacks, Sangeeta N. Bhatia
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The activity of multiple enzymes is dysregulated in cancer, but this cannot always be measured through enzyme expression. Here, the authors develop methods to measure protease activity across the organism, tissue, and single cell scales, and identify
Externí odkaz:
https://doaj.org/article/5a1de31fec07440a8a18a30ec793bde0
Autor:
Alex S Genshaft, Carly G. K. Ziegler, Constantine N. Tzouanas, Benjamin E. Mead, Alex M. Jaeger, Andrew W. Navia, Ryan P. King, Miyeko D. Mana, Siyi Huang, Vanessa Mitsialis, Scott B. Snapper, Ömer H. Yilmaz, Tyler Jacks, Jeffrey F. Van Humbeck, Alex K. Shalek
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Spatial transcriptomics aims to pair omic data with tissue structure. Here the authors report Spatially PhotoActivatable Colour Encoded Cell Address Tags (SPACECAT) to track and isolate live cells by location; this enables spatially informed downstre
Externí odkaz:
https://doaj.org/article/1dca5ab3f8864e5791c305a732202ce2
Autor:
Alex S. Genshaft, Carly G. K. Ziegler, Constantine N. Tzouanas, Benjamin E. Mead, Alex M. Jaeger, Andrew W. Navia, Ryan P. King, Miyeko D. Mana, Siyi Huang, Vanessa Mitsialis, Scott B. Snapper, Ömer H. Yilmaz, Tyler Jacks, Jeffrey F. Van Humbeck, Alex K. Shalek
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/0b468f9130d74759b3659b72de40c8d2
Autor:
Rocio Gomez-Pastor, Eileen T. Burchfiel, Daniel W. Neef, Alex M. Jaeger, Elisa Cabiscol, Spencer U. McKinstry, Argenia Doss, Alejandro Aballay, Donald C. Lo, Sergey S. Akimov, Christopher A. Ross, Cagla Eroglu, Dennis J. Thiele
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Huntington’s disease (HD) is caused by misfolding of mutant Htt protein. The authors find that in HD models, the decreased expression of heat shock transcription factor 1 that usually protects against protein misfolding, is in part caused by elevat
Externí odkaz:
https://doaj.org/article/10e213fe581949ff9cd3a516b23f2861
Autor:
Daniel W. Neef, Alex M. Jaeger, Rocio Gomez-Pastor, Felix Willmund, Judith Frydman, Dennis J. Thiele
Publikováno v:
Cell Reports, Vol 9, Iss 3, Pp 955-966 (2014)
Heat shock transcription factor 1 (HSF1) is an evolutionarily conserved transcription factor that protects cells from protein-misfolding-induced stress and apoptosis. The mechanisms by which cytosolic protein misfolding leads to HSF1 activation have
Externí odkaz:
https://doaj.org/article/52d1219d3ab343a2a033a9ffa76fb02e
1408 Non-canonical peptide sources broaden the landscape of targetable antigens in pancreatic cancer
Autor:
Philip D Greenberg, Eva K Verzani, Jennifer G Abelin, Alex M Jaeger, Tyler Jacks, Andrew J Aguirre, Susan Klaeger, Zackery A Ely, Zachary J Kulstad, Sudarsana Addepalli, Karl Clauser, Kevin S Kapner, Connor J Hennessey, Miles Agus, Jennifer Su, Steven Carr, William Freed-Pastor
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/8c9ce62a787d46bc806b7e8d7e0b414a
Autor:
Bin Fang, John Koomen, Paul Stewart, Alex M Jaeger, William Rideout, Tyler Jacks, Andrew Weeden, Anika Ali, Victoria Izumi, Emma Sanders
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/bbeb0658bb9044afb29fc9c9c3091144
Autor:
Roderick Bronson, Arjun Bhutkar, Peter MK Westcott, Francesc Muyas, Haley Hauck, Olivia C Smith, Nathan Sacks, Zack Ely, Alex M Jaeger, William Rideout, Daniel D Zhang, Mary Clare Beytagh, David Canner, Santiago Naranjo, Abbey Jin, Justin Patten, Amanda M Cruz, Sean-Luc Shanahan, Isidro Cortes-Ciriano, Tyler Jacks
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/f7ec3338903e4e67abbdc5790810ff7e