Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Pedro R. Lowenstein"'
Autor:
Syed M. Faisal, Jarred E. Clewner, Brooklyn Stack, Maria L. Varela, Andrea Comba, Grace Abbud, Sebastien Motsch, Maria G. Castro, Pedro R. Lowenstein
Publikováno v:
Advanced Science, Vol 11, Iss 18, Pp n/a-n/a (2024)
Abstract Glioblastoma (GBM) remains a challenge in Neuro‐oncology, with a poor prognosis showing only a 5% survival rate beyond two years. This is primarily due to its aggressiveness and intra‐tumoral heterogeneity, which limits complete surgical
Externí odkaz:
https://doaj.org/article/1538c238cfc34c618bb0253cf99982f3
Autor:
Sree Deepthi Muthukrishnan, Riki Kawaguchi, Pooja Nair, Rachna Prasad, Yue Qin, Maverick Johnson, Qing Wang, Nathan VanderVeer-Harris, Amy Pham, Alvaro G. Alvarado, Michael C. Condro, Fuying Gao, Raymond Gau, Maria G. Castro, Pedro R. Lowenstein, Arjun Deb, Jason D. Hinman, Frank Pajonk, Terry C. Burns, Steven A. Goldman, Daniel H. Geschwind, Harley I. Kornblum
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Therapeutic stress induces phenotypic plasticity in glioma stem cells although the mechanisms underlying this remain poorly understood. Here, the authors show that P300 mediates the radiation-induced vascular-like conversion of glioma stem cells to p
Externí odkaz:
https://doaj.org/article/2f813af486a84bc6939ddacebcf2e7f8
Autor:
Andrea Comba, Syed M. Faisal, Patrick J. Dunn, Anna E. Argento, Todd C. Hollon, Wajd N. Al-Holou, Maria Luisa Varela, Daniel B. Zamler, Gunnar L. Quass, Pierre F. Apostolides, Clifford Abel, Christine E. Brown, Phillip E. Kish, Alon Kahana, Celina G. Kleer, Sebastien Motsch, Maria G. Castro, Pedro R. Lowenstein
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)
It is essential to improve our understanding of the features that influence aggressiveness and invasion in high grade gliomas (HGG). Here, the authors characterize dynamic anatomical structures in HGG called oncostreams, which are associated with tum
Externí odkaz:
https://doaj.org/article/3b351a9de1174a41bae1168e3664c972
Autor:
Jason V. Gregory, Padma Kadiyala, Robert Doherty, Melissa Cadena, Samer Habeel, Erkki Ruoslahti, Pedro R. Lowenstein, Maria G. Castro, Joerg Lahann
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The lack of effective drug delivery strategies has impaired the therapeutic progress in the treatment of glioblastoma (GBM). Here, the authors engineer synthetic protein nanoparticle based on polymerized human serum albumin equipped with the cell-pen
Externí odkaz:
https://doaj.org/article/b30c04bdef1f4073bda6bbf46a097b78
Autor:
Jantzen Sperry, Michael C. Condro, Lea Guo, Daniel Braas, Nathan Vanderveer-Harris, Kristen K.O. Kim, Whitney B. Pope, Ajit S. Divakaruni, Albert Lai, Heather Christofk, Maria G. Castro, Pedro R. Lowenstein, Janel E. Le Belle, Harley I. Kornblum
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101453- (2020)
Summary: Glioblastoma (GBM) metabolism has traditionally been characterized by a primary dependence on aerobic glycolysis, prompting the use of the ketogenic diet (KD) as a potential therapy. In this study we evaluated the effectiveness of the KD in
Externí odkaz:
https://doaj.org/article/c408bc708ce74fd297a8a89e0dcb76f3
Autor:
Hikmat Assi, Jaclyn Espinosa, Sarah Suprise, Michael Sofroniew, Robert Doherty, Daniel Zamler, Pedro R Lowenstein, Maria G Castro
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96318 (2014)
Cellular microenvironments, particularly those found in tumors, elicit a tolerogenic DC phenotype which can attenuate immune responses. Central to this process is the STAT3-mediated signaling cascade. As a transcription factor and oncogene, STAT3 pro
Externí odkaz:
https://doaj.org/article/1badbe9865b844839678f4753af0c7a6
Autor:
Mariana Puntel, Robert Barrett, Nicholas S R Sanderson, Kurt M Kroeger, Niyati Bondale, Mia Wibowo, Sean Kennedy, Chunyan Liu, Maria G Castro, Pedro R Lowenstein
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23523 (2011)
CD8(+) T cells infiltrate the brain during an anti-viral immune response. Within the brain CD8(+) T cells recognize cells expressing target antigens, become activated, and secrete IFNγ. However, there are no methods to recognize individual cells tha
Externí odkaz:
https://doaj.org/article/56d63cd621844155953612e6ed9b7931
Autor:
Weidong Xiong, Marianela Candolfi, Chunyan Liu, A K M Ghulam Muhammad, Kader Yagiz, Mariana Puntel, Peter F Moore, Julie Avalos, John D Young, Dorothy Khan, Randy Donelson, G Elizabeth Pluhar, John R Ohlfest, Kolja Wawrowsky, Pedro R Lowenstein, Maria G Castro
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11074 (2010)
Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults and carries a dismal prognosis. We have developed a conditional cytotoxic/immunotherapeutic approach using adenoviral vectors (Ads) encoding the immunostimulatory cytokine
Externí odkaz:
https://doaj.org/article/7bbf55f8e7c44fb68695fec0b43c154f
Autor:
Carlos Barcia, Nicholas S R Sanderson, Robert J Barrett, Kolja Wawrowsky, Kurt M Kroeger, Mariana Puntel, Chunyan Liu, Maria G Castro, Pedro R Lowenstein
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e2977 (2008)
Astrocytes usually respond to trauma, stroke, or neurodegeneration by undergoing cellular hypertrophy, yet, their response to a specific immune attack by T cells is poorly understood. Effector T cells establish specific contacts with target cells, kn
Externí odkaz:
https://doaj.org/article/b5648ab732a5454e9e7696deb81e3252
Autor:
James F Curtin, Marianela Candolfi, Tamer M Fakhouri, Chunyan Liu, Anderson Alden, Matthew Edwards, Pedro R Lowenstein, Maria G Castro
Publikováno v:
PLoS ONE, Vol 3, Iss 4, p e1983 (2008)
Regulatory T lymphocytes (Treg) infiltrate human glioblastoma (GBM); are involved in tumor progression and correlate with tumor grade. Transient elimination of Tregs using CD25 depleting antibodies (PC61) has been found to mediate GBM regression in p
Externí odkaz:
https://doaj.org/article/46b3f6c2f18f483a9fbab5a9a6c65683