Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Angelo M. De Marzo"'
Autor:
Hannah E. Bergom, Laura A. Sena, Abderrahman Day, Benjamin Miller, Carly D. Miller, John R. Lozada, Nicholas Zorko, Jinhua Wang, Eugene Shenderov, Francisco Pereira Lobo, Fernanda Caramella-Pereira, Luigi Marchionni, Charles G. Drake, Tamara Lotan, Angelo M. De Marzo, Justin Hwang, Emmanuel S. Antonarakis
Publikováno v:
npj Genomic Medicine, Vol 9, Iss 1, Pp 1-9 (2024)
Abstract Patients with prostate cancer (PC) generally do not respond favorably to immune checkpoint inhibitors, which may be due to a low abundance of tumor-infiltrating lymphocytes even when mutational load is high. Here, we identified a patient who
Externí odkaz:
https://doaj.org/article/a63fc47e643a46939677c01b1b4e10df
Autor:
Laura A. Sena, Rajendra Kumar, David E. Sanin, Elizabeth A. Thompson, D. Marc Rosen, Susan L. Dalrymple, Lizamma Antony, Yuhan Yang, Carolina Gomes-Alexandre, Jessica L. Hicks, Tracy Jones, Kiara A. Bowers, Jillian N. Eskra, Jennifer Meyers, Anuj Gupta, Alyza Skaist, Srinivasan Yegnasubramanian, Jun Luo, W. Nathaniel Brennen, Sushant K. Kachhap, Emmanuel S. Antonarakis, Angelo M. De Marzo, John T. Isaacs, Mark C. Markowski, Samuel R. Denmeade
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 23 (2022)
Testosterone is the canonical growth factor of prostate cancer but can paradoxically suppress its growth when present at supraphysiological levels. We have previously demonstrated that the cyclical administration of supraphysiological androgen (SPA),
Externí odkaz:
https://doaj.org/article/1190b8e3606d4217ab6c491c95462033
Autor:
William G. Nelson, Otis W. Brawley, William B. Isaacs, Elizabeth A. Platz, Srinivasan Yegnasubramanian, Karen S. Sfanos, Tamara L. Lotan, Angelo M. De Marzo
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 3 (2022)
Prostate cancer exerts a greater toll on African American men than on White men of European descent (hereafter referred to as European American men): the disparity in incidence and mortality is greater than that of any other common cancer. The dispro
Externí odkaz:
https://doaj.org/article/efe4325533a14b22bf895c05a7fb49fa
Autor:
W. Nathaniel Brennen, Yezi Zhu, Ilsa M. Coleman, Susan L. Dalrymple, Lizamma Antony, Radhika A. Patel, Brian Hanratty, Roshan Chikarmane, Alan K. Meeker, S. Lilly Zheng, Jody E. Hooper, Jun Luo, Angelo M. De Marzo, Eva Corey, Jianfeng Xu, Srinivasan Yegnasubramanian, Michael C. Haffner, Peter S. Nelson, William G. Nelson, William B. Isaacs, John T. Isaacs
Publikováno v:
JCI Insight, Vol 6, Iss 8 (2021)
Resistance to AR signaling inhibitors (ARSis) in a subset of metastatic castration-resistant prostate cancers (mCRPCs) occurs with the emergence of AR– neuroendocrine prostate cancer (NEPC) coupled with mutations/deletions in PTEN, TP53, and RB1 an
Externí odkaz:
https://doaj.org/article/f6df29103c0e46759e5821f89b231584
Autor:
Binod Kumar, Avi Z. Rosenberg, Su Mi Choi, Karen Fox-Talbot, Angelo M. De Marzo, Larisa Nonn, W. Nathaniel Brennen, Luigi Marchionni, Marc K. Halushka, Shawn E. Lupold
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract MiR-1 and miR-143 are frequently reduced in human prostate cancer (PCa), while miR-141 and miR-21 are frequently elevated. Consequently, these miRNAs have been studied as cell-autonomous tumor suppressors and oncogenes. However, the cell-typ
Externí odkaz:
https://doaj.org/article/6a8d5bc00c9b474db0d4de545fbb6069
Autor:
Kirstie Canene-Adams, Karen S. Sfanos, Chung-Tiang Liang, Srinivasan Yegnasubramanian, William G. Nelson, Cory Brayton, Angelo M. De Marzo
Publikováno v:
PLoS ONE, Vol 9, Iss 1 (2014)
Externí odkaz:
https://doaj.org/article/ef995220b30f448fbe3e68f554af8956
Autor:
Kirstie Canene-Adams, Karen S. Sfanos, Chung-Tiang Liang, Srinivasan Yegnasubramanian, William G. Nelson, Cory Brayton, Angelo M. De Marzo
Publikováno v:
PLoS ONE, Vol 9, Iss 1 (2014)
Externí odkaz:
https://doaj.org/article/d53c843962d94689ae011780e1dffb84
Autor:
Igor Vidal, Qizhi Zheng, Jessica L Hicks, Jiayu Chen, Elizabeth A Platz, Bruce J Trock, Ibrahim Kulac, Javier A Baena-Del Valle, Karen S Sfanos, Sarah Ernst, Tracy Jones, Janielle P Maynard, Stephanie A Glavaris, William G Nelson, Srinivasan Yegnasubramanian, Angelo M De Marzo
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0241934 (2021)
GSTP1 is a member of the Glutathione-S-transferase (GST) family silenced by CpG island DNA hypermethylation in 90-95% of prostate cancers. However, prostate cancers expressing GSTP1 have not been well characterized. We used immunohistochemistry again
Externí odkaz:
https://doaj.org/article/f8b82cf97d47488885f04952aabfccf4
Autor:
Kirstie Canene-Adams, Karen S Sfanos, Chung-Tiang Liang, Srinivasan Yegnasubramanian, William G Nelson, Cory Brayton, Angelo M De Marzo
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79842 (2013)
The heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-B]pyridine (PhIP), found in meats cooked at high temperatures, has been implicated in epidemiological and rodent studies for causing breast, prostate, and colorectal cancers. A previous ani
Externí odkaz:
https://doaj.org/article/e6c1b0f651d446ce91f4a8965aae10cd
Autor:
Matthew P Vaughn, Debika Biswal Shinohara, Nicole Castagna, Jessica L Hicks, George Netto, Angelo M De Marzo, Traci J Speed, Zachery R Reichert, Bernard Kwabi-Addo, Colin J Henderson, C Roland Wolf, Srinivasan Yegnasubramanian, William G Nelson
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25707 (2011)
Glutathione S-transferases (GSTs) metabolize drugs and xenobiotics. Yet despite high protein sequence homology, expression of π-class GSTs, the most abundant of the enzymes, varies significantly between species. In mouse liver, hepatocytes exhibit h
Externí odkaz:
https://doaj.org/article/07fb1536d03c43a3a08c8dafe7106551