Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Yong J. Lee"'
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-13 (2020)
Abstract Background Mucinous colon cancers (MCC) are characterized by abundant production of mucin 2 (MUC2) protein and are less sensitive to standard systemic chemotherapy. We postulated that severe/persistent endoplasmic reticulum stress (ERS) aggr
Externí odkaz:
https://doaj.org/article/3cea977c93ed4b929f91cf219f252bbf
Publikováno v:
Cancer Medicine, Vol 9, Iss 5, Pp 1753-1767 (2020)
Abstract Molecular‐targeted therapies have demonstrated disappointing results against most advanced solid cancers. This may largey be attributed to irrational drug use against unselected cancers. We investigated the efficacy of dual MEK‐PI3K drug
Externí odkaz:
https://doaj.org/article/12a75ad4899c4fccac51f4dc6ad15f41
Autor:
Weilin Liu, Hongqi Chen, Zhi Zhu, Zuqiang Liu, Congrong Ma, Yong J. Lee, David L. Bartlett, Zong-Sheng Guo
Publikováno v:
Biomedicines, Vol 10, Iss 6, p 1425 (2022)
Ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides. In this study, we explore the combination of a ferroptosis activator with an oncolytic vaccinia virus in tumor models. Erastin
Externí odkaz:
https://doaj.org/article/845fcbfbe9d346f2adef10925b7e5237
Publikováno v:
International Journal of Biological Sciences, Vol 7, Iss 1, Pp 102-111 (2011)
During the immune response, neutrophils display localized mechanical events by interacting with their environment through the micro-vascular transit, trans-endothelial, and trans-epithelial migration. Nano-mechanical studies of human neutrophils on l
Externí odkaz:
https://doaj.org/article/4c14f18edfd04e0dabbe2aca3a9323c2
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 9, Iss 5, Pp 1753-1767 (2020)
Cancer Medicine, Vol 9, Iss 5, Pp 1753-1767 (2020)
Molecular‐targeted therapies have demonstrated disappointing results against most advanced solid cancers. This may largey be attributed to irrational drug use against unselected cancers. We investigated the efficacy of dual MEK‐PI3K drug therapy
Autor:
Lesley M. Foley, Hima Makala, Haroon A. Choudry, Robin Frederick, Ashok K. Dilly, Jianxia Guo, David L. Bartlett, Jan H. Beumer, T. Kevin Hitchens, Yong J. Lee, Brendon D. Honick, Anuleka Elapavaluru, Lora H. Rigatti, Sachin Velankar
Publikováno v:
Transl Res
Abundant intraperitoneal (IP) accumulation of extracellular mucus in patients with appendiceal mucinous carcinoma peritonei (MCP) causes compressive organ dysfunction and prevents delivery of chemotherapeutic drugs to cancer cells. We hypothesized th
Autor:
Marco A. Alcala, Hyounsoo Uh, Yong J. Lee, Ruth A. Modzelewski, Shu Ying Kwan, Kristy A. Gogick, David L. Bartlett, Stéphane Petoud, Adam R. Meier, Matthias Bischof, Chad M. Shade, Timothy G. Strein, Charles K. Brown, Zachary P. Thompson
Publikováno v:
Biomaterials
Biomaterials, Elsevier, 2011, 32 (35), pp.9343-52. ⟨10.1016/j.biomaterials.2011.07.076⟩
Biomaterials, Elsevier, 2011, 32 (35), pp.9343-52. ⟨10.1016/j.biomaterials.2011.07.076⟩
International audience; We have created a dendrimer complex suitable for preferential accumulation within liver tumors and luminescence imaging by substituting thirty-two naphthalimide fluorophores on the surface of the dendrimer and incorporating ei
Publikováno v:
Food and Chemical Toxicology. 49:271-280
Astaxanthin (AST) is a powerful antioxidant that occurs naturally in a wide variety of living organisms. We have investigated the role of AST in preventing 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced apoptosis of the substantia nigra
Publikováno v:
Journal of Clinical Biochemistry and Nutrition
Astaxanthin (ATX), a naturally occurring carotenoid pigment, is a powerful biological antioxidant. In the present study, we investigated whether ATX pharmacologically offers neuroprotection against oxidative stress by cerebral ischemia. We found that
Autor:
Marco A. Alcala, Yong Tae Kwon, Miroslaw J. Szczepanski, Joo Hang Kim, So Young Kim, Jee Young An, David L. Bartlett, Yong J. Lee, Jae J. Song
Publikováno v:
Cellular Signalling. 22:553-563
We previously reported two modes of development of acquired TRAIL resistance: early phase and late phase [1]. In these studies, we observed that greater Akt activity and the expression of Bcl-xL were related mainly to the late phase of acquired TRAIL