Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Vitor A. Lira"'
Autor:
Jianling Bi, Emily Witt, Megan K. McGovern, Arielle B. Cafi, Lauren L. Rosenstock, Anna B. Pearson, Timothy J. Brown, Thomas B. Karasic, Lucas C. Absler, Srija Machkanti, Hannah Boyce, David Gallo, Sarah L. Becker, Keiko Ishida, Joshua Jenkins, Alison Hayward, Alexandra Scheiflinger, Kellie L. Bodeker, Ritesh Kumar, Scott K. Shaw, Salma K. Jabbour, Vitor A. Lira, Michael D. Henry, Michael S. Tift, Leo E. Otterbein, Giovanni Traverso, James D. Byrne
Publikováno v:
Advanced Science, Vol 11, Iss 9, Pp n/a-n/a (2024)
Abstract Modulation of autophagy, specifically its inhibition, stands to transform the capacity to effectively treat a broad range of cancers. However, the clinical efficacy of autophagy inhibitors has been inconsistent. To delineate clinical and epi
Externí odkaz:
https://doaj.org/article/f858b9587aa7486a8b205a415ae94226
Autor:
George R. Marcotte, Matthew J. Miller, Hawley E. Kunz, Zachary C. Ryan, Matthew D. Strub, Patrick M. Vanderboom, Carrie J. Heppelmann, Sarah Chau, Zachary D. Von Ruff, Sean P. Kilroe, Andrew T. McKeen, Jason M. Dierdorff, Jennifer I. Stern, Karl A. Nath, Chad E. Grueter, Vitor A. Lira, Andrew R. Judge, Blake B. Rasmussen, K. Sreekumaran Nair, Ian R. Lanza, Scott M. Ebert, Christopher M. Adams
Publikováno v:
JCI Insight, Vol 8, Iss 22 (2023)
Aging and many illnesses and injuries impair skeletal muscle mass and function, but the molecular mechanisms are not well understood. To better understand the mechanisms, we generated and studied transgenic mice with skeletal muscle–specific expres
Externí odkaz:
https://doaj.org/article/af1307b64c1b4419953e38f85ed47944
Autor:
Christie M. Penniman, Gourav Bhardwaj, Colette J. Nowers, Chandler U. Brown, Taylor L. Junck, Cierra K. Boyer, Jayashree Jena, Jordan D. Fuqua, Vitor A. Lira, Brian T. O'Neill
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 1, Pp 243-259 (2023)
Abstract Background Muscle mitochondrial decline is associated with aging‐related muscle weakness and insulin resistance. FoxO transcription factors are targets of insulin action and deletion of FoxOs improves mitochondrial function in diabetes. Ho
Externí odkaz:
https://doaj.org/article/c9f129a6962c4f9aa5ecf446caaba8e4
Autor:
Victor Lamin, Joseph Verry, Olumayowa S. Dokun, Ana Kronemberger, Thomas Wong, Vitor A. Lira, Ayotunde O. Dokun
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 16 (2022)
Background Peripheral artery disease is caused by atherosclerotic occlusion of vessels outside the heart and most commonly affects vessels of the lower extremities. Angiogenesis is a part of the postischemic adaptation involved in restoring blood flo
Externí odkaz:
https://doaj.org/article/dc2f88d9f651400888d2476a78f60cc3
Autor:
Matthew P. Harris, Shemin Zeng, Zhiyong Zhu, Vitor A. Lira, Liping Yu, Denice M. Hodgson-Zingman, Leonid V. Zingman
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6525 (2023)
This study investigates the role and mechanisms by which the myokine musclin promotes exercise-induced cardiac conditioning. Exercise is one of the most powerful triggers of cardiac conditioning with proven benefits for healthy and diseased hearts. T
Externí odkaz:
https://doaj.org/article/0f3f177315eb46f697f8fd6b87451851
Autor:
Gilmar Weber Senna, Estélio Henrique Martin Dantas, Estevão Scudese, Paula Paraguassú Brandão, Vitor A. Lira, Matheus Baffi, Luiz Claudio Pereira Ribeiro, Roberto Simão, Ewan Thomas, Antonino Bianco
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
ObjectivesThe aim of the manuscript was to analyze the effects of two rest periods between volume-equated resistance exercise (RE) on inflammatory responses (cytokines and leukocyte) and muscle damage.MethodsTen trained men (26.40 ± 4.73 years, 80.7
Externí odkaz:
https://doaj.org/article/745ef91de4714d76bfb13fc8e0440005
Autor:
Sara C. Sebag, Zeyuan Zhang, Qingwen Qian, Mark Li, Zhiyong Zhu, Mikako Harata, Wenxian Li, Leonid V. Zingman, Limin Liu, Vitor A. Lira, Matthew J. Potthoff, Alexander Bartelt, Ling Yang
Publikováno v:
Cell Reports, Vol 37, Iss 7, Pp 110003- (2021)
Summary: Brown adipose tissue (BAT) thermogenic activity is tightly regulated by cellular redox status, but the underlying molecular mechanisms are incompletely understood. Protein S-nitrosylation, the nitric-oxide-mediated cysteine thiol protein mod
Externí odkaz:
https://doaj.org/article/fa993ffe513b402bb490e9e9850283d2
Autor:
Kristen D. Turner, Ana Kronemberger, Dam Bae, Joshua M. Bock, William E. Hughes, Kenichi Ueda, Andrew J. Feider, Satoshi Hanada, Luis G. O. de Sousa, Matthew P. Harris, Ethan J. Anderson, Sue C. Bodine, M. Bridget Zimmerman, Darren P. Casey, Vitor A. Lira
Publikováno v:
Nutrients, Vol 14, Iss 21, p 4479 (2022)
Nitric oxide (NO) stimulates mitochondrial biogenesis in skeletal muscle. However, NO metabolism is disrupted in individuals with type 2 diabetes mellitus (T2DM) potentially contributing to their decreased cardiorespiratory fitness (i.e., VO2max) and
Externí odkaz:
https://doaj.org/article/f0c4a9ef66794e1fb98cdb528fdffe87
Autor:
Victor Lamin, Joseph Verry, Isaac Eigner-Bybee, Jordan D. Fuqua, Thomas Wong, Vitor A. Lira, Ayotunde O. Dokun
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 429 (2021)
Both Type 1 diabetes mellitus (DM1) and type 2 diabetes mellitus (DM2) are associated with an increased risk of limb amputation in peripheral arterial disease (PAD). How diabetes contributes to poor PAD outcomes is poorly understood but may occur thr
Externí odkaz:
https://doaj.org/article/b6a7ec37e0aa4f289f4ae3261ff89c8d
Autor:
Rhianna C. Laker, Joshua C. Drake, Rebecca J. Wilson, Vitor A. Lira, Bevan M. Lewellen, Karen A. Ryall, Carleigh C. Fisher, Mei Zhang, Jeffrey J. Saucerman, Laurie J. Goodyear, Mondira Kundu, Zhen Yan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Exercise is associated with biogenesis and removal of dysfunctional mitochondria. Here the authors use a mitochondrial reporter gene to demonstrate the occurrence of mitophagy following exercise in mice, and show this is dependent on AMPK and ULK1 si
Externí odkaz:
https://doaj.org/article/45800b0013144c79a5f7f403114864d6