Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Supachoke Mangmool"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5763 (2024)
Cardiovascular diseases (CVDs), particularly heart failure, are major contributors to early mortality globally. Heart failure poses a significant public health problem, with persistently poor long-term outcomes and an overall unsatisfactory prognosis
Externí odkaz:
https://doaj.org/article/a6105b0412f94b1b8513df9d19e587d4
Autor:
Sutharinee Likitnukul, Surapun Tepaarmorndech, Theerayuth Kaewamatawong, Arunrat Yangchum, Chanathip Duangtha, Pimrapat Jongjang, Supachoke Mangmool, Darawan Pinthong, Masahiko Isaka
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Introduction: Non-alcoholic fatty liver disease (NAFLD) is one of the metabolic disorders related to the pathophysiology of type 2 diabetes mellitus (T2DM). Therapeutic strategies are focused on the improvement of energy balance and lifestyle modific
Externí odkaz:
https://doaj.org/article/80bc93be0ab24c918ec9e9967025f342
Autor:
Sayaka Oda, Kazuhiro Nishiyama, Yuka Furumoto, Yohei Yamaguchi, Akiyuki Nishimura, Xiaokang Tang, Yuri Kato, Takuro Numaga-Tomita, Toshiyuki Kaneko, Supachoke Mangmool, Takuya Kuroda, Reishin Okubo, Makoto Sanbo, Masumi Hirabayashi, Yoji Sato, Yasuaki Nakagawa, Koichiro Kuwahara, Ryu Nagata, Gentaro Iribe, Yasuo Mori, Motohiro Nishida
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Baroreflex control of cardiac contractility is essential to maintain cardiocirculatory homeostasis. Here, Oda et al show that α1 adrenoceptor-stimulated Zn2+ entry through TRPC6 channels boosts β adrenoceptor-dependent myocardial positive inotropy.
Externí odkaz:
https://doaj.org/article/e32d11cf533d41b3a910892e7315812a
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12866 (2023)
Current drugs for treating heart failure (HF), for example, angiotensin II receptor blockers and β-blockers, possess specific target molecules involved in the regulation of the cardiac circulatory system. However, most clinically approved drugs are
Externí odkaz:
https://doaj.org/article/4c3c08c81be24494b3df5008f46e0913
Publikováno v:
Pharmaceuticals, Vol 16, Iss 6, p 836 (2023)
Diabetes is one of the chronic metabolic disorders which poses a multitude of life-debilitating challenges, including cardiac muscle impairment, which eventually results in heart failure. The incretin hormone glucagon-like peptide-1 (GLP-1) has gaine
Externí odkaz:
https://doaj.org/article/357daffe2b0e4f5a9030babc121108a4
Autor:
Natthinee Anantachoke, Ratchanee Duangrat, Tanyarat Sutthiphatkul, Duangjai Ochaikul, Supachoke Mangmool
Publikováno v:
Foods, Vol 12, Iss 9, p 1818 (2023)
Kombucha is a traditional health beverage produced by fermenting sweetened tea with a symbiotic culture of bacteria and yeasts. Consumption of kombucha beverages has been growing and there is kombucha commercially available worldwide as one of the mo
Externí odkaz:
https://doaj.org/article/871a5dd2c234424683aa437aca4717de
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 6972 (2023)
Angiotensin II (Ang II) upregulates transforming growth factor-beta1 (TGF-β1) and endothelin-1 (ET-1) in various types of cells, and all of them act as profibrotic mediators. However, the signal transduction of angiotensin II receptor (ATR) for upre
Externí odkaz:
https://doaj.org/article/91f05f4c458646ba8028b5d0e0f137b7
Autor:
Sutharinee Likitnukul, Sumpun Thammacharoen, Orada Sriwatananukulkit, Chanathip Duangtha, Ruedee Hemstapat, Chotchanit Sunrat, Supachoke Mangmool, Darawan Pinthong
Publikováno v:
Biomedicines, Vol 11, Iss 4, p 1050 (2023)
Obesity has been linked to metabolic syndrome, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD). Obesity causes a decrease in growth hormone (GH) levels and an increase in insulin levels. Long-term GH treatment increased lipolytic activ
Externí odkaz:
https://doaj.org/article/53d387e76cbb4e01b0b7cd18e9a0467d
Autor:
Sutthaorn Pothongsrisit, Kuntarat Arunrungvichian, Yoshihiro Hayakawa, Boonchoo Sritularak, Supachoke Mangmool, Varisa Pongrakhananon
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Cancer metastasis is a major cause of the high mortality rate in lung cancer patients. The cytoskeletal rearrangement and degradation of extracellular matrix are required to facilitate cell migration and invasion and the suppression of these
Externí odkaz:
https://doaj.org/article/67797f6c65354f42a5bfc90390e197d3
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4475 (2023)
Endothelin-1 (ET-1) has been implicated in the pathogenesis of cardiac fibrosis. Stimulation of endothelin receptors (ETR) with ET-1 leads to fibroblast activation and myofibroblast differentiation, which is mainly characterized by an overexpression
Externí odkaz:
https://doaj.org/article/39685eadf3d34c54a92760c6b95d48b5