Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Stephen A Murray"'
Autor:
Anna L Swan, Christine Schütt, Jan Rozman, Maria Del Mar Muñiz Moreno, Stefan Brandmaier, Michelle Simon, Stefanie Leuchtenberger, Mark Griffiths, Robert Brommage, Piia Keskivali-Bond, Harald Grallert, Thomas Werner, Raffaele Teperino, Lore Becker, Gregor Miller, Ala Moshiri, John R Seavitt, Derek D Cissell, Terrence F Meehan, Elif F Acar, Christopher J Lelliott, Ann M Flenniken, Marie-France Champy, Tania Sorg, Abdel Ayadi, Robert E Braun, Heather Cater, Mary E Dickinson, Paul Flicek, Juan Gallegos, Elena J Ghirardello, Jason D Heaney, Sylvie Jacquot, Connor Lally, John G Logan, Lydia Teboul, Jeremy Mason, Nadine Spielmann, Colin McKerlie, Stephen A Murray, Lauryl M J Nutter, Kristian F Odfalk, Helen Parkinson, Jan Prochazka, Corey L Reynolds, Mohammed Selloum, Frantisek Spoutil, Karen L Svenson, Taylor S Vales, Sara E Wells, Jacqueline K White, Radislav Sedlacek, Wolfgang Wurst, K C Kent Lloyd, Peter I Croucher, Helmut Fuchs, Graham R Williams, J H Duncan Bassett, Valerie Gailus-Durner, Yann Herault, Ann-Marie Mallon, Steve D M Brown, Philipp Mayer-Kuckuk, Martin Hrabe de Angelis, IMPC Consortium
Publikováno v:
PLoS Genetics, Vol 16, Iss 12, p e1009190 (2020)
The genetic landscape of diseases associated with changes in bone mineral density (BMD), such as osteoporosis, is only partially understood. Here, we explored data from 3,823 mutant mouse strains for BMD, a measure that is frequently altered in a ran
Externí odkaz:
https://doaj.org/article/14895730ccd5432c954b9d406684a8d3
Autor:
David C Katz, J David Aponte, Wei Liu, Rebecca M Green, Jessica M Mayeux, K Michael Pollard, Daniel Pomp, Steven C Munger, Stephen A Murray, Charles C Roseman, Christopher J Percival, James Cheverud, Ralph S Marcucio, Benedikt Hallgrímsson
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0233377 (2020)
The biology of how faces are built and come to differ from one another is complex. Discovering normal variants that contribute to differences in facial morphology is one key to untangling this complexity, with important implications for medicine and
Externí odkaz:
https://doaj.org/article/6a6a871e7a96439fbe99f3557fe52694
Autor:
Lydia Teboul, James Amos-Landgraf, Fernando J. Benavides, Marie-Christine Birling, Steve D. M. Brown, Elizabeth Bryda, Rosie Bunton-Stasyshyn, Hsian-Jean Chin, Martina Crispo, Fabien Delerue, Michael Dobbie, Craig L. Franklin, Ernst-Martin Fuchtbauer, Xiang Gao, Christelle Golzio, Rebecca Haffner, Yann Hérault, Martin Hrabe de Angelis, Kevin C. Kent Lloyd, Terry R. Magnuson, Lluis Montoliu, Stephen A. Murray, Ki-Hoan Nam, Lauryl M. J. Nutter, Eric Pailhoux, Fernando Pardo Manuel de Villena, Kevin Peterson, Laura Reinholdt, Radislav Sedlacek, Je Kyung Seong, Toshihiko Shiroishi, Cynthia Smith, Toru Takeo, Louise Tinsley, Jean-Luc Vilotte, Søren Warming, Sara Wells, C. Bruce Whitelaw, Atsushi Yoshiki, Asian Mouse Mutagenesis Resource Association, CELPHEDIA infrastructure, INFRAFRONTIER consortium, International Mammalian Genome Society, International Mouse Phenotyping Consortium, International Society for Transgenic Technologies, Mutant Mouse Resource and Research Centers, Phenomics Australia, RRRC- Rat Resource and Research Center, Guillaume Pavlovic
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-8 (2024)
Abstract The biomedical research community addresses reproducibility challenges in animal studies through standardized nomenclature, improved experimental design, transparent reporting, data sharing, and centralized repositories. The ARRIVE guideline
Externí odkaz:
https://doaj.org/article/81e4d92fe0424d7c9017a0c563ae6724
Autor:
John P Sundberg, Tong Shen, Oliver Fiehn, Robert H Rice, Kathleen A Silva, Victoria E Kennedy, Nicholas E Gott, Louise A Dionne, Lesley S Bechtold, Stephen A Murray, Raoul Kuiper, C Herbert Pratt
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205775 (2018)
In a large scale screen for skin, hair, and nail abnormalities in null mice generated by The Jackson Laboratory's KOMP center, homozygous mutant Far2tm2b(KOMP)Wtsi/2J (hereafter referrred to as Far2-/-) mice were found to develop focal areas of alope
Externí odkaz:
https://doaj.org/article/54573e0a95f049668de7342ab1349d2c
Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.
Autor:
John P Sundberg, Soheil S Dadras, Kathleen A Silva, Victoria E Kennedy, Gaven Garland, Stephen A Murray, Beth A Sundberg, Paul N Schofield, C Herbert Pratt
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180682 (2017)
The International Knockout Mouse Consortium was formed in 2007 to inactivate ("knockout") all protein-coding genes in the mouse genome in embryonic stem cells. Production and characterization of these mice, now underway, has generated and phenotyped
Externí odkaz:
https://doaj.org/article/9f38595f5cf14dd1a56dbfcda9d20c9b
Autor:
Robert A Taft, Benjamin E Low, Shannon L Byers, Stephen A Murray, Peter Kutny, Michael V Wiles
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e67826 (2013)
There is a continual need to improve efficiency in creating precise genetic modifications in mice using embryonic stem cells (ESCs). We describe a novel approach resulting in 100% germline transmission from competent injected ESCs. We developed an F1
Externí odkaz:
https://doaj.org/article/0fb319c35da548dc9a430f4682cf6fd0
Autor:
Yan Xu, Yanhua Wang, Valérie Besnard, Machiko Ikegami, Susan E Wert, Caleb Heffner, Stephen A Murray, Leah Rae Donahue, Jeffrey A Whitsett
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e37046 (2012)
The timing of lung maturation is controlled precisely by complex genetic and cellular programs. Lung immaturity following preterm birth frequently results in Respiratory Distress Syndrome (RDS) and Broncho-Pulmonary Dysplasia (BPD), which are leading
Externí odkaz:
https://doaj.org/article/5c117a1e05264bb9a93b8f8a4a11faf9
Autor:
Valérie Besnard, Susan E Wert, Machiko Ikegami, Yan Xu, Caleb Heffner, Stephen A Murray, Leah Rae Donahue, Jeffrey A Whitsett
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e26682 (2011)
Among all mammals, fetal growth and organ maturation must be precisely synchronized with gestational length to optimize survival at birth. Lack of pulmonary maturation is the major cause of infant mortality in preterm birth. Whether fetal or maternal
Externí odkaz:
https://doaj.org/article/696dba101caa4e3d956a23190a7fc9d3
Autor:
Stephen A Murray, Judith L Morgan, Coleen Kane, Yashoda Sharma, Caleb S Heffner, Jeffrey Lake, Leah Rae Donahue
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12418 (2010)
Preterm birth is an enormous public health problem, affecting over 12% of live births and costing over $26 billion in the United States alone. The causes are complex, but twin studies support the role of genetics in determining gestation length. Desp
Externí odkaz:
https://doaj.org/article/9ce882918e4547c69ef7c151f01fc360
Autor:
Kevin A. Peterson, Sam Khalouei, Nour Hanafi, Joshua A. Wood, Denise G. Lanza, Lauri G. Lintott, Brandon J. Willis, John R. Seavitt, Robert E. Braun, Mary E. Dickinson, Jacqueline K. White, K. C. Kent Lloyd, Jason D. Heaney, Stephen A. Murray, Arun Ramani, Lauryl M. J. Nutter
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract Genome editing with CRISPR-associated (Cas) proteins holds exceptional promise for “correcting” variants causing genetic disease. To realize this promise, off-target genomic changes cannot occur during the editing process. Here, we use w
Externí odkaz:
https://doaj.org/article/f7798291f4934fd091966e0b3ee6f881