Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Stanislav John"'
Autor:
Michal Kroupa, Ondrej Kubecek, Kristyna Tomasova, Petr Hanak, Marketa Krupova, Klara Cervena, Anna Siskova, Jachym Rosendorf, Petr Hosek, Ludmila Vodickova, Pavel Vodicka, Vaclav Liska, Stanislav John, Veronika Vymetalkova, Jiri Petera
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Telomeric sequences, the structures comprised of hexanucleotide repeats and associated proteins, play a pivotal role in chromosome end protection and preservation of genomic stability. Herein we address telomere length (TL) dynamics in prima
Externí odkaz:
https://doaj.org/article/e208be7268cb49858512e83c538d6774
Autor:
Josef Horak, Ondrej Kubecek, Anna Siskova, Katerina Honkova, Irena Chvojkova, Marketa Krupova, Monika Manethova, Sona Vodenkova, Sandra García-Mulero, Stanislav John, Filip Cecka, Ludmila Vodickova, Jiri Petera, Stanislav Filip, Veronika Vymetalkova
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Despite distant metastases being the critical factor affecting patients’ survival, they remain poorly understood. Our study thus aimed to molecularly characterize colorectal cancer liver metastases (CRCLMs) and explore whether molecular profiles di
Externí odkaz:
https://doaj.org/article/e8f2282a449d4e539c6f4ba856f3ae77
Autor:
Milan Vošmik, Jindřich Kopecký, Stanislav John, Ondřej Kubeček, Petr Lochman, Aml Mustafa Banni, Libor Hruška, Igor Sirák
Publikováno v:
Cancers, Vol 13, Iss 18, p 4591 (2021)
The following main treatment approaches are currently used in locally advanced adenocarcinomas of the oesophagus and gastrooesophageal junction (GOJ): preoperative chemoradiotherapy and surgery, and perioperative chemotherapy and surgery. While preop
Externí odkaz:
https://doaj.org/article/ffe8fac64282485ba44439e0352e9d57
Publikováno v:
Biomedical Papers, Vol 161, Iss 4, Pp 360-368 (2017)
Background: Colorectal carcinoma is one of the most common malignancies in western countries. Among different approaches to its research, primary cancer cell lines can play an important role. Aim: The main purposes of this study were: 1) to establish
Externí odkaz:
https://doaj.org/article/5a4c7a32030a4e0aab8440097789eb53
Autor:
Stanislav Filip, Veronika Vymetalkova, Jiri Petera, Ludmila Vodickova, Ondrej Kubecek, Stanislav John, Filip Cecka, Marketa Krupova, Monika Manethova, Klara Cervena, Pavel Vodicka
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 15, p 5255 (2020)
Colorectal cancer (CRC) remains a serious health problem worldwide. Approximately half of patients will develop distant metastasis after CRC resection, usually with very poor prognosis afterwards. Because patient performance after distant metastasis
Externí odkaz:
https://doaj.org/article/3a58b2e296934c5389b9b04fdc44b440
Publikováno v:
Acta Medica, Vol 51, Iss 1, Pp 51-57 (2008)
Zinc has been shown to have inhibitory effects on proliferation and metabolism of malignant colonocytes. Still, there is no information available concerning putative effects of zinc against motility and migration of colon cancer cells. Using fluoresc
Externí odkaz:
https://doaj.org/article/e4ca350b7d2e4fb19b425cd399b28996
Publikováno v:
Toxicology Letters. 214:1-8
Irinotecan (CPT-11) is topoisomerase I inhibitor used in the treatment of disseminated colorectal cancer. In colon cancer cells it induces DNA damage which leads to cytotoxicity with ensuing apoptosis or premature senescence. Despite its clinical use
Publikováno v:
Toxicology Letters. 196:S309